Evaluation of the effectiveness of diet therapy enriched with insoluble dietary fibers in patients with hyperlipoproteinemia

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Background. The use of dietary fibers in the prevention and treatment of cardiovascular diseases has a convincing evidence base. In particular, a meta-analysis of prospective cohort studies revealed a significant association between dietary fiber intake and a reduced risk of mortality from all causes in general and from cardiovascular diseases in particular. A 9% reduction in cardiovascular mortality and a 9–11% reduction in coronary artery disease mortality were found with additional dietary fiber intake of 7–10 g/day. Currently, only dietary fiber sources and dosages are the subject of debate in the global medical community.

Objective. Evaluation of the effectiveness of diet therapy enriched with insoluble dietary fibers (IDFs) in patients with hyperlipoproteinemia (HLP).

Methods. An open, single-center prospective study was conducted at the Federal Research Center of Nutrition and Biotechnology. The tolerability and effectiveness of diet therapy enriched with IDFs were assessed, with a daily dietary fiber intake of 38.8 g. The effectiveness was monitored based on the dynamics of the cardiovascular system (CVS) functional activity parameters, anthropometry, and lipid profile.

Results. The diet therapy course was shown to be well tolerated, had a beneficial effect on the clinical picture of diseases and the dynamics of clinical and instrumental indices characterizing the functional state of the cardiovascular system, and potentiated the hypotensive and hypolipidemic effects of the diet, with a statistically significant decrease in systolic blood pressure by 20% (p<0.01), diastolic blood pressure by 19%, a significant reduction in total serum cholesterol by 24% (p<0.01), low-density lipoprotein levels by 33% (p<0.01) and the atherogenicity coefficient by 29% (p<0.05).

Conclusion. In order to increase the efficiency of correction of existing lipid metabolism disorder and complete prevention of development of cardiovascular diseases, it is advisable, modernly and promising to use sources of IDFs with provision of total daily amount of IDFs in diet of not less than 35 g in patients with HLP.

Full Text

Restricted Access

About the authors

S. A. Derbeneva

Federal Research Center for Nutrition and Biotechnology

Email: 89151479832@mail.ru
ORCID iD: 0000-0003-1876-1230
Russian Federation, Moscow

Svetlana V. Shmeleva

K.G. Razumovsky Moscow State University of Technologies and Management

Author for correspondence.
Email: 89151479832@mail.ru
ORCID iD: 0000-0003-0390-194X

Dr. Sci. (Med.), Professor

Russian Federation, Moscow

S. B. Kachalov

State University of Management

Email: 89151479832@mail.ru
ORCID iD: 0000-0003-0887-4995
Russian Federation, Moscow

L. V. Elgarova

Medical Academy of Kabardino-Balkarian State University named after Kh.M. Berbekov

Email: 89151479832@mail.ru
ORCID iD: 0000-0002-7149-7830
Russian Federation, Nalchik

References

  1. Fox K.A.A., Metra M., Morais J., et al. The myth of ‘stable’ coronary artery disease. Nat Rev Cardiol. 2020;17(1):9–21. doi: 10.1038/s41569-019-0233-y.
  2. Li J.T., Kim S-Ah, Shin S. Association between Three Low-Carbohydrate Diet Scores and Lipid Metabolism among Chinese Adults. Nutrients. 2020;12:1307. doi: 10.3390/nu12051307.
  3. Всемирная Организация Здравоохранения. [Электронный ресурс]. – Ожирение и избыточный вес. 2020. https://www.who.int/ru/news-room/fact-sheets/detail/obesity-and-overweight (Дата обращения: 03.08.2021). [The World Health Organization. [electronic resource]. – Obesity and overweight. 2020. https://www.who.int/ru/news-room/fact-sheets/detail/obesity-and-overweight (Date of access: 08/03/2021). (In Russ.)].
  4. Trautwein E.A., McKay S. The Role of Specific Components of a Plant-Based Diet in Management of Dyslipidemia and the Impact on Cardiovascular Risk. Nutrients. 2020;12(9):2671. doi: 10.3390/nu12092671.
  5. Evans C.E.L. Dietary fibre and cardiovascular health: A review of current evidence and policy. Proc Nutr Soc. 2020;79:61–67. doi: 10.1017/S0029665119000673.
  6. Stephen A.M., Champ M.M., Cloran S.J., et al. Dietary fibre in Europe: Currentstate of knowledge on definitions, sources, recommendations, intakes and relationships to health. Nutr Res Rev. 2017;30:149–190. doi: 10.1017/S095442241700004X.
  7. Harley L., May M.D., Loveman E., et al. Dietary fibre for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2016;1:CD011472.
  8. Anderson J.W., Baird P., Davis R.H.J., et al. Health benefits of dietary fiber. Nutr. Rev. 2009;67(4):188–205.
  9. Шмелева С.В. Метаболические изменения у женщин в климактерическом периоде. Физическая реабилитация детей, взрослых и инвалидов. 2005;1-2:7–11. [Shmeleva S.V. Metabolic changes in women in the menopausal period. Physical rehabilitation of children, adults and the disabled. 2005;1-2:7–11. (In Russ.)].
  10. Шмелева С.В., Манухин И.Б., Тактаров В.Г. Постменопауза и ее осложнения. Вопросы гинекологии, акушерства и перинатологии. 2008;7.(6):96–98. [Shmeleva S.V., Manukhin I.B., Taktarov V.G. Postmenopause and its complications. Issues of gynecology, obstetrics and perinatology. 2008;7.(6):96–98. (In Russ.)].
  11. Kim Y., Je Y. Dietary fibre intake and mortality from cardiovascular disease and all cancers: A meta-analysis of prospective cohort studies. Arch Cardiovasc Dis. 2016;109(1):39–54. doi: 10.1016/j.acvd.2015.09.005.
  12. McRae M.P. Dietary fiber is beneficial for the prevention of cardiovascular disease: An umbrella review of Meta-analyses. J. Chiropr. Med. 2017;16:289–299. doi: 10.1016/j.jcm.2017.05.005.
  13. Stephen A.M., Champ M.M., Cloran S.J., et al. Dietary fibre in Europe: Currentstate of knowledge on definitions, sources, recommendations, intakes and relationships to health. Nutr. Res. Rev. 2017;30:149–190. doi: 10.1017/S095442241700004X.
  14. Mach F., Baigent C., Catapano A.L., et al. ESC Scientific Document Group. 2019 ESC/EAS Guidelines for the management of dyslipidaemias: Lipid modification to reduce cardiovascular risk. Eur. Heart J. 2020;41:111–188. doi: 10.1093/eurheartj/ehz455.
  15. Бойцов С.А., Погосова Н.В., Аншелес А.А. и др. Кардиоваскулярная профилактика. 2022. Российские национальные рекомендации. Российский кардиологический журнал. 2023;28(5):5452. doi: 10.15829/1560-4071-2023-5452. EDN EUDWYG [Boitsov S.A., Pogosova N.V., Ansheles A.A., et al. Cardiovascular prevention. 2022. Russian national recommendations. Russian Journal of Cardiology. 2023;28(5):5452. doi: 10.15829/1560-4071-2023-5452. (In Russ.)].

Supplementary files

Supplementary Files
Action
1. JATS XML
Download
2. Fig. Dynamics of changes in lipidogram parameters

Download (46KB)
Indexing metadata

Copyright (c) 2025 Bionika Media