Comorbidity of psoriasis and periodontal diseases

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Abstract

Psoriasis is one of the most common skin diseases and occurs in 2-3% of the population; it affects about 125 million people worldwide. Several decades ago, it was considered an exclusively skin disease, but today it is considered a chronic multifactorial, multisystem, immune-mediated inflammatory disease with a complex pathogenetic mechanism caused by chronic activation of adaptive and innate immune responses due to excessive proliferation of keratinocytes with the development of latent multiorgan cellular destruction and dysfunction.

Periodontal diseases are among the most common human diseases and the first cause of tooth loss in adults. At the beginning of the 21st century, the concept of «periodontal medicine» was formed, considering the relationship between periodontal pathology and systemic diseases. Currently, more than 50 systemic inflammatory diseases and concomitant diseases are associated with periodontal pathology.

We searched the Pubmed and Scopus information databases for articles published before 01/21/2025 that examined the relationship between psoriasis and periodontitis. The results of epidemiological and clinical studies, their generalizations in systematic reviews and meta-analyses indicate the presence of a bidirectional relationship between psoriasis and periodontitis. The most likely mechanism is associated with systemic immune-mediated inflammation. Non-surgical periodontal treatment is probably effective in the treatment of psoriasis. The data presented in the review indicate the importance of periodontal health and the need for prevention and treatment of periodontal pathology in patients with psoriasis.

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About the authors

Dmitry I. Trukhan

Omsk State Medical University

Author for correspondence.
Email: dmitry_trukhan@mail.ru
ORCID iD: 0000-0002-1597-1876

Dr. Sci. (Med.) Associate Professor, Professor, Department of Outpatient Therapy and Internal Medicine

Russian Federation, Omsk

Anatoly F. Sulimov

Omsk State Medical University

Email: afsulimov@yandex.ru

Dr. Sci. (Med.), Professor Head of the Department of Maxillofacial Surgery, Omsk State Medical University

Russian Federation, Omsk

Larisa Yu. Trukhan

Omsk State Medical University

Email: larissa_trukhan@mail.ru
ORCID iD: 0000-0002-4721-6605

Cand. Sci. (Med.), dentist

Russian Federation, Omsk

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