Senotherapeutic biorevitalization

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Abstract

Aging is a natural biological process that affects all levels of life organization. Understanding the mechanisms of aging is of great importance for developing effective strategies for the prevention and treatment of the phenomenon of premature aging in cosmetology, dermatology and aesthetic medicine. Cellular aging – senescence, is considered one of the central links in the aging process. Research in this area can lead to the development of new methods for locally slowing down the aging process, treating the phenomenon of premature aging and increasing the effectiveness of the procedures. One of the promising areas in the framework of injection cosmetology is biorevitalization – an invasive procedure aimed at restoring and optimizing the quality characteristics of the skin, in particular the intercellular matrix. This work is devoted to the description of a new direction of biorevitalization based on a multimarker approach within the framework of molecular cosmetology – senotherapeutic biorevitalization or senobirevitalization. The effect of this group of drugs is achieved by intradermal administration of a gel containing hyaluronic acid with additional senotherapeutic components. These components contribute to the partial or complete blockade of pathways associated with the expression of the senescence associated secretory phenotype (SASP) without cell death. The article also examines in detail the regulation and functional role of SASP, the mechanism of action of senotherapeutic drugs, their advantages and prospects for the development of this direction.

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About the authors

V. N. Khabarov

Research Center for Hyaluronic Acid

Email: d.znatdinov@nicgk.com
ORCID iD: 0009-0008-8271-5507
Russian Federation, Moscow

D. I. Znatdinov

Research Center for Hyaluronic Acid

Author for correspondence.
Email: d.znatdinov@nicgk.com
ORCID iD: 0009-0001-3227-4415

Junior Researcher

Russian Federation, Moscow

L. S. Kholupova

Central State Medical Academy of the Administrative Directorate of the President of the Russian Federation

Email: d.znatdinov@nicgk.com
ORCID iD: 0000-0002-2781-4587
Russian Federation, Moscow

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