Zloupotreblenie alkogolem i alkogol'naya bolezn' pecheni
- Authors: Kalinin A.V1
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Affiliations:
- Issue: No 13 (2012)
- Pages: 19-25
- Section: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/279733
- ID: 279733
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Abstract
Alcoholic liver disease (ALD) remains an urgent problem of modern medicine. High rates of mortality and disability in patients with this disease constantly force to seek new ways to prevent or reduce the harmful effects of alcohol on internal organs, primarily on the liver. Only the complete exclusion of alcohol leads to significant positive effect up to the restoration of normal liver structure. The use of membrane-stabilizing drugs (essential phospholipids, S-adenosylmethionine, ursodeoxycholic acid) is most promising treatment. In therapy of ALD, the use of Thiogamma (thioctic acid) provides antioxidant and antitoxic effect. Severe acute alcoholic hepatitis (AAH), especially in the presence of hepatic encephalopathy, is an indication for glucocorticoids. Cumulative data on the role of proinflammatory cytokines in the pathogenesis of the AHH were the rationale for attempts to introduce anticytokine drugs into clinical practice.
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References
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