BONDRONAT - OPYT PRIMENENIYa U BOL'NYKh S KOSTNYMI METASTAZAMI RAKA MOLOChNOY ZhELEZY


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Abstract

Bondronat (ibandronic acid) is a representative of group of bisphosphonates, which exists both in intravenous and in oral forms, that significantly expands the possibilities of its application. In patients with bone metastases from breast cancer (BC), approximately equal efficacy of two dosage forms of Bondronat (6 mg intravenously every 4 weeks and 50 mg/day per os continuously) in the prevention of skeletal events, expressed in reducing their risk by 40 % was demonstrated. Recent studies show that Bondronat is an appropriate alternative to zoledronate in the therapy of bone metastases from breast cancer. Application of oral form of Bondronat in patients who do not require intravenous administration of drugs and frequent monitoring of peripheral blood (for example, hormonal treatment of breast cancer) is particularly promising. Almost complete absence of renal toxicity of intravenous form of Bondronat allows to use intensive regimens (for 3 consecutive days) for painful bone metastases, without any problems.

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N. N Semenov

References

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