TSEVERE PSORIASIS IN CHILDHOOD
- Authors: Murashkin N.N1, Ambarchyan E.T1, Materikin A.I1, Epishev R.V1
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Affiliations:
- FSAI “Scientific Center of Children's Health" of RMH
- Issue: No 11 (2016)
- Pages: 34-39
- Section: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/289061
- ID: 289061
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Open Access
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Abstract
The article presents current data about the features of the course of severe psoriasis in children. The phenotypic heterogeneity of dermatosis in children, caused by gene polymorphism and multifactorial nature of the pathogenetic processes, is described. The importance of identifying the type of mutation during the genetic testing is emphasized; it has a great importance for the diagnosis, treatment and prognosis of the disease. The authors draw attention to the impact of comorbid conditions on the severity of psoriasis in children at different ages. Also, data on rare forms of psoriasis in childhood are presented in the article.
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About the authors
N. N Murashkin
FSAI “Scientific Center of Children's Health" of RMH
Email: m_nn2001@mail.ru
MD, Prof, Head of the Department of Dermatology Moscow
E. T Ambarchyan
FSAI “Scientific Center of Children's Health" of RMHMoscow
A. I Materikin
FSAI “Scientific Center of Children's Health" of RMHMoscow
R. V Epishev
FSAI “Scientific Center of Children's Health" of RMHMoscow
References
- Баранов А.А., Намазова-Баранова Л.С., Мурашкин Н.Н., Круглова Л.С., Епишев Р.В., Амбарчян Э.Т., Материкин А.И. Федеральные клинические рекомендации по оказанию медицинской помощи детям с псориазом. 2016. С. 5-10.
- Schön M.R, Boehncke W.H. Psoriasis. N. Engl. J. Med. 2005;352:1899-1912.
- Paller A.S., Mancini A.J. Hurwitz Clinical Pediatric Dermatology, 5th edition. 2016. P. 73.
- Rapp S.R., Feldman S.R., Exum M.L., Fleischer A.B. Jr, Reboussin D.M. Psoriasis causes as much disability as other major medical diseases. J. Am. Acad. Dermatol. 1999;41:401-7.
- Christophers E. Psoriasis - epidemiology and clinical spectrum. Clin. Exp. Dermatol. 2001;26:314-20.
- Augustin M., Glaeske G., Radtke M.A., Christophers E., Reich K., Schäfer I. Epidemiology and comorbidity of psoriasis in children. Br. J. Dermatol. 2010;162:633-36.
- Becker L., Tom W.L., Eshagh K., Benjamin L.T., Paller A.S. Excess adiposity preceding pediatric psoriasis. JAMA Dermatol. 2014;150(5):573-74.
- Griffiths C.E.M., Barker J.N.W.N. Pathogenesis and clinical features of psoriasis. Lancet. 2007;370:263-71.
- Nestle F.O., Kaplan D.H., Barker J. Psoriasis. N. Engl. J. Med. 2009;361:496-509.
- Boehncke S., Salgo R., Garbaraviciene J., Beschmann H., Hardt K., Diehl S., Fichtlscherer S., Thaçi D., Boehncke W.H. Effective continuous systemic therapy of severe plaque-type psoriasis is accompanied by amelioration of biomarkers of cardiovascular risk: results of a prospective longitudinal observational study. J. Eur. Acad. Dermatol. Venereol. 2011;25:1187-93.
- Armstrong A.W., Voyles S.V., Armstrong E.J., Fuller E.N., Rutledge J.C. A tale of two plaques: convergent mechanisms of T-cell-mediated inflammation in psoriasis and atherosclerosis. Exp. Dermatol. 2011;20:544-49.
- Boehncke W.H., Boehncke S., Tobin A.M., Kirby B. The 'psoriatic march': a concept of how severe psoriasis may drive cardiovascular comorbidity. Exp. Dermatol. 2011;20:303-7.
- Besgen P., Trommler P., Vollmer S., Prinz J.C. Ezrin, maspin, peroxiredoxin 2, and heat shock protein 27: potential targets of a streptococcal-induced autoimmune response in psoriasis. J. Immunol. 2010;184:5392-5402.
- Mercy K., Kwasny M., Cordoro K.M., Menter A., Tom W.L., Korman N., Belazarian L., Armstrong A.W., Levy M.L., Palier A.S. Clinical manifestations of pediatric psoriasis: results of multicenter study in the United States. Pediatr. Dermatol. 2013;30(4):424-28.
- Martin B.A., Chalmers R.J., Telfer N.R. How great is the risk of further psoriasis following a single episode of acute guttate psoriasis? Аrchю Dermatol. 1996;132:717-18.
- Вольф К., Голдсмит Л.А., Кац С.И. и др. Дерматология Фицпатрика в клинической практике. Т. 1. 2012. 192 с.
- Boehncke W.H., Schön M.P. Psoriasis. Lancet. 2015;386(9997):983-94.
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