TREATMENT OF SEIZURES AND STATUS EPILEPTICUS IN INTENSIVE CARE UNIT OF GENERAL PEDIATRIC HOSPITAL: EXPERIENCE OF USE OF INTRAVENOUS VALPROIC ACID


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Abstract

The article describes the experience of the use of valproic acid for parenteral administration in the intensive care unit of general pediatric hospital. 93 patients with prolonged epileptic seizures and status epilepticus were observed in the ICU within 6 months. Majority of admitted patients were diagnosed with epilepsy (77%), other patients had different somatic diagnoses. Valproic acid in the form of a solution for parenteral administration was used for the treatment of status epilepticus in 94.5% of cases. The drug proved to be easy to use (with no dilution), a very efficient, and had a favorable safety profile.

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About the authors

I. O Schederkina

SBHCIMHCD Morozov Children's City Clinical Hospital; SBEIHPE RNSMU n.a. N.I. Pirogov of RMH

Email: schederkina@bk.ru
PhD, Head of the Center for the treatment of cerebrovascular pathology in children and adolescents; an Assistant Professor at the Department of Neurology, Neurosurgery and Medical Genetics of Faculty of Pediatrics Moscow

N. A Maslova

SBHCIMHCD Morozov Children's City Clinical Hospital; SBEIHPE RNSMU n.a. N.I. Pirogov of RMH

Moscow

L. P Semenova

SBHCIMHCD Morozov Children's City Clinical Hospital

Moscow

I. E Koltunov

SBHCIMHCD Morozov Children's City Clinical Hospital; Peoples' Friendship University of Russia

Moscow

E. E Petryaikina

SBHCIMHCD Morozov Children's City Clinical Hospital; Peoples' Friendship University of Russia

Moscow

N. N. Zavadenko

SBHCIMHCD Morozov Children's City Clinical Hospital; SBEIHPE RNSMU n.a. N.I. Pirogov of RMH

Moscow

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