Immunological indicators in the diagnosis of allergic bronchial asthma
- Authors: Asiryan E.G1
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Affiliations:
- Vitebsk State Order of Peoples' Friendship Medical University
- Issue: Vol 26, No 10 (2019)
- Pages: 71-76
- Section: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/312244
- DOI: https://doi.org/10.18565/pharmateca.2019.10.71-76
- ID: 312244
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Abstract
Background. Currently, a number of laboratory methods are used to confirm the presence of allergies, however, confirming the diagnosis of allergic bronchial asthma (ABA) remains a challenge. Objective. Determination of the immunological criteria for ABA. Methods. 160 children aged 6 to 18 years were examined, including 130 patients with ABA and 30 children in the control group. The relative and absolute CD19+, CD19+CD23++ B-lymphocyte, CD23+IgE+-eosinophil levels were determined. Results. The level of B-lymphocytes carrying the CD19+CD23++ receptor serves as a highly informative diagnostic criterion for patients with ABA. With absolute values of the CD19+CD23++ B-lymphocyte level 23.23 cells^l, and a relative level of >5.40%, it is possible to say with a high degree of confidence that the patient has ABA. To confirm the diagnosis of ABA, the CD23+IgE+-eosinophil level should be determined. With an absolute value of the level of these cells of >73.01 cells/iJl and a relative level of >35.10%, it is possible to say with a high degree of confidence about the presence of ABA in the patient. Conclusion. To confirm the diagnosis of ABA, the CD19+CD23++ B-lymphocyte and CD23+IgE+-eosinophil levels should be determined.
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About the authors
E. G Asiryan
Vitebsk State Order of Peoples' Friendship Medical University
Email: lena.asiryn@mail.ru
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