Scientific prerequisites and prospects for the use of sildenafil in patients with COVID-19


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Currently, there are only theoretical prerequisites for using the sildenafil to treat patients with COVID-19. There is no clinical evidence to recommend the use of this drug in real clinical practice to prevent and alleviate symptoms in patients with COVID-19. The use of sildenafil in the treatment of a new coronavirus infection is possible only within the framework of clinical trials.

Full Text

Restricted Access

About the authors

V. M Tsvetov

Federal Center for Cardiovascular Surgery

Chelyabinsk, Russia

A. V Matveev

Russian Medical Academy of Continuous Professional Education

Moscow, Russia

References

  1. Государственный реестр лекарственных средств (Электронный ресурс). [State Register of Medicines (Electronic resource). (In Russ.)]. URL: http://grls.rosminzdrav.ru/Grls_ View_ v2.aspx?routingGuid=88e3ecde-ddbc-4f04-99bc-e4419c9bd4c7&t=.
  2. Limodio M, et al. Hypothesis of COVID-19 Therapy with Sildenafil. Int J Prev Med. 2020;11:76. Doi: 10.4103/ ijpvm.IJPVM_258_20.
  3. Государственный реестр лекарственных средств (Электронный ресурс). [State Register of Medicines (Electronic resource). (In Russ.)]. URL: http://grls.rosminzdrav.ru/Grls_ View_ v2.aspx?routing Guid=cb3ec347-bdc9-403f-b07b-158a9f23084e&t=
  4. EU Clinical Trials Register [Electronic resource]. URL: https://clinicaltrials.gov/ct2/results?cond=Co vid19&te rm=&type=&rslt=&age_v=&gndr=&intr=Sildenafil
  5. The National Center for Biotechnology Information advances science and health by providing access to biomedical and genomic information [Electronic resource]. URL: https://pubmed.ncbi.nlm.nih.gov/?ter m=covid+19+and+sildenafil
  6. Isidori A.M., et al. Targeting the NO-cGMP-PDE5 pathway in COVID-19 infection. The DEDALO project. Andrology 2021;9(1):33-8. doi: 10.1111/and. 12837.
  7. Dal Moro F., et al. The war against the SARS-CoV2 infection: Is it better to fight or mitigate it? Med. Hypotheses. 2020;143:110129. Doi: 10.1016/j. mehy.2020. 110129.
  8. Shirvaliloo M. Targeting the SARS-CoV-2 3CLpn} and NO/ cGMP/PDE5 pathway in COVID-19: a commentary on PDE5 inhibitors. Future Cardiol. 2021 Feb 12;10.2217/ fca-2020-0201. doi: 10.2217/fca-2020-0201.
  9. Hutchings D.C., Anderson S.G., Caldwell J.L., Trafford A.W. Phosphodiesterase-5 inhibitors and the heart: compound cardioprotection? Heart. 2018;104(15):1244-50. Doi: 10.1136/ heartjnl-2017-312865.
  10. Giannetta E., Isidori A.M., Galea N., et al. Chronic inhibition of cGMP phosphodiesterase 5A improves diabetic cardiomyopathy: a randomized, controlled clinical trial using magnetic resonance imaging with myocardial tagging. Circulation. 2012;125(19):2323-33. doi: 10.1161/CIRCULATIONAHA.111.063412.
  11. Wu R., Wang L., Kuo H.C.D., et al. An update on current therapeutic drugs treating COVID-19. Curr Pharmacol Reports. 2020;6(3):56-70. doi: 10.1007/s40495-020-00216-7.
  12. Mario L., Roberto M., Marta L., et al. Hypothesis of COVID-19 therapy with sildenafil. Int J Prev Med.
  13. Qiao Z., Zhang H., Ji H.F., Chen Q. Computational view toward the inhibition of SARS-CoV-2 spike glycoprotein and the 3CL protease. Computation. 2020;8(2):53. doi: 10.3390/computation8020053.
  14. Временные методические рекомендации. Профилактика, диагностика и лечение новой коронавирусной инфекции (COVID-19). 7-е изд., М., 2020. 261 c.
  15. Giuliano F., Jackson G., Montorsi F., et al. Safety of sildenafil citrate: review of 67 double-blind placebo-controlled trials and the postmarketing safety database. Int J Clin Pract. 2010;64(2):240-55. doi: 10.1111/j.1742-1241.2009.02254.x.
  16. Laties A., Sharlip I. Ocular safety in patients using sildenafil citrate therapy for erectile dysfunction. J Sex Med. 2006;3(1):12-27. doi: 10.1111/j.1743-6109.2005.00194.x.
  17. Blonde L. Sildenafil citrate for erectile dysfunction in men with diabetes and cardiovascular risk factors: a retrospective analysis of pooled data from placebo-controlledtrials. CurrMedResOpin. 2006;22(11):2111-20. doi: 10.1185/030079906X148256.

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2021 Bionika Media

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies