Modern antiretroviral therapy in children and its side effects in the practice of a dermatovenerologist


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Abstract

The article is devoted to a review of the literature on modern antiretroviral therapy (ARVT) in children and its side effects in the practice of a dermatovenerologist. The issues of the goals of AVRT in children, indications for its prescription, classification and mechanism of action of antiretroviral drugs, and current starting regimens for HIV treatment in children are discussed. The article also addresses the classification of the side effects of ARVT in children, their features in this age category and in the practice of a dermatovenerologist.

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About the authors

O. N Pozdnyakova

Novosibirsk State Medical University

Novosibirsk, Russia

S. G Bychkov

Novosibirsk State Medical University

Email: stasbychkov9409@mail.ru
Novosibirsk, Russia

O. B Nemchaninova

Novosibirsk State Medical University

Novosibirsk, Russia

G. S Karpovich

Novosibirsk State Medical University

Novosibirsk, Russia

T. B Reshetnikova

Novosibirsk State Medical University

Novosibirsk, Russia

References

  1. Клинические рекомендации «ВИЧ-инфекция у детей». Национальная ассоциация специалистов по профилактике, диагностике и лечению ВИЧ-инфекции. 2017. @@CHnicai guidelines «HIV infection in children.» National Association of Specialists in the Prevention, Diagnostics and Treatment of HIV Infection. 2017.(ln Russ.).
  2. World Heaths Organization. HIV/AIDS. Available: https://www.who.int/ru/news-room/fact-sheets/detail/hiv-aids
  3. Abdela J, Assefa A., Shamele S. Prevalence of Adverse Drug Reactions among Pediatric Patients on Antiretroviral Therapy in Selected Hospitals in Eastern Ethiopia: 8-Year Retrospective Cross-Sectional Study J Int Assoc Provid AIDS Care. 2019;18:2325958218823208. doi: 10.1177/2325958218823208.
  4. Bonawitz R, Brennan A.T., Long L., et al. Regimen durability in HIV-infected children and adolescents initiating first-line antiretroviral therapy in a large public sector HIV cohort in South Africa. Trop Med Int Health. 2018;23(6):650-60. Doi: 10.1111/ tmi.13057.
  5. Wynberg E., Williams E., Tudor-Williams G., et al. Discontinuation of Efavirenz in Paediatric Patients: Why do Children Switch? Clin Drug Investig. 2018;38(3):231-38. doi: 10.1007/s40261-017-0605-1.
  6. Fortuny C., Dey-Mart nez, Chiappini E., et al. Metabolic and renal adverse effects of antiretroviral therapy in HIV-infected children and adolescents. Pediatr Infect Dis J. 2015;34(5 Suppl 1):S36-43. doi: 10.1097/INF.0000000000000663.
  7. Li Y.Y., Yang S.H., Wang R.R., et al. Effects of CD4 cell count and antiretroviral therapy on mucocutaneous manifestations among HIV/ AIDS patients in Yunnan, China. Int J Dermatol. 2020;59(3):308-13. doi: 10.1111/ijd.14725.
  8. Williams P.L., Correia K., Karalius B., et al.; Pediatric HIV/AIDS Cohort Study Cardiac status of perinatally HIV-infected children: assessing combination antiretroviral regimens in observational studies. AIDS. 2018;32(16):2337-346. Doi: 10.1097/ QAD.0000000000001988.
  9. Национальная ассоциация специалистов по профилактике, диагностике и лечению ВИЧ-инфекции. Таблица по антиретровирусным препаратам. @@National Association of Specialists in the Prevention, Diagnostics and Treatment of HIV Infection. Table for antiretroviral drugs. (In Russ.)]. URL: http://rushiv.ru/drugs-table/
  10. Клинические рекомендации «ВИЧ-инфекция у взрослых». Национальная ассоциация специалистов по профилактике, диагностике и лечению ВИЧ-инфекции. 2020. @@Clinical guidelines «HIV infection in adults». National Association of Specialists in the Prevention, Diagnostics and Treatment of HIV Infection. 2020. (In Russ.).
  11. «Лечение и помощь при ВИЧ-инфекции у детей». Клинический протокол для Европейского региона ВОЗ (обновленная версия 2012 г). Всемирная организация здравоохранения. 2012. @@«Treatment and care for HIV infection in children». Clinical Protocol for the WHO European Region (2012 update). World Health Organization. 2012. (In Russ.).
  12. Paganella M.P, Cohen R.A., Harris D.R., et al. NISDI PLACES Protocol. Association of Dyslipidemia and Glucose Abnormalities With Antiretroviral Treatment in a Cohort of HIV-Infected Latin American Children. J Acquir Immune DeficSyndr 2017;74(1):e1-e8. Doi: 10.1097/ QAI.0000000000001163.
  13. Dejkhamron P, Unachak K., Aurpibul L., Sirisanthana V Insulin resistance and lipid profiles in HIV-infected Thai children receiving lopinavir/ ritonavir-based highly active antiretroviral therapy. J Pediatr Endocrinol Metab. 2014;27(5-6):403-12. doi: 10.1515/jpem-2013-0253.
  14. Kanters S, Vitoria M., Doherty M., et al. Comparative efficacy and safety of first-line antiretroviral therapy for the treatment of HIV infection: a systematic review and network metaanalysis. Lancet HIV. 2016;3(11):e510-e520. doi: 10.1016/S2352-3018(16)30091-1.
  15. McComsey G.A., Leonard E. Metabolic complications of HIV therapy in children. AIDS. 2004;18:1753-68. doi: 10.1097/00002030-200409030-00004.
  16. Songa P.M., et al. Symptomatic hyperlactatemia associated with nucleoside analogue reverse-transcriptase inhibitor use in HIV-infected patients: a report of 24 cases in a resource-limited setting (Uganda). Clin Infect Dis. 2007;45:514-17. doi: 10.1086/520023.
  17. Reisler R.B., et al. Incidence of pancreatitis in HIV-1-infected individuals enrolled in 20 Adult AIDS Clinical Trials Group studies: lessons learned. J Acquir Immune Defic Syndr 2005;39:159-66.
  18. Mantula A.A. Features of dermatological pathology in patients with chronic hepatitis. Dermatol Venereol. 2009;4(46):41-5.
  19. Позднякова О.Н., Немчанинова О.Б., Спицы-на А.В. и др. Нозологическая структура и особенности течения дерматозов у больных с заболеваниями печени и желчных путей. Экспериментальная и клиническая гастроэнтерология. 2018;155(7):91-6. @@Pozdnyakova O.N., Nemchaninova O.B., Spitsyna A.V., et al. Nosological structure and features of the course of dermatoses in patients with liver and biliary tract diseases. Eksperimental'naya i klinicheskaya gastroenterologiya. 2018;155(7):91-6. (In Russ.).
  20. Torres-Navarro I., Rojas-Ferrer N., Botella-Estrada R. Pancreatic panniculitis. Rev EspEnferm Dig. 2019;111(10):812-13. Doi: 10.17235/ reed.2019.6116/2018.
  21. Vigand A., Cerini C., Pattarino G., et al. Metabolic complications associated with antiretroviral therapy in HIV-infected and HIV-exposed uninfected paediatric patients. Expert Opin Drug Saf. 2010;9(3):431-45. doi: 10.1517/14740330903579991. PMID: 20078250.
  22. Bhutia E., Hemal A., Yadav T.P, Ramesh KL. Lipodystrophy syndrome among HIV infected children on highly active antiretroviral therapy in northern India. Afr Health Sci. 2014;14(2):408-13. doi: 10.4314/ahs.v14i2.17.
  23. Sarni R.O., Souza F.I., Battistini T.R., et al. Lipodystrophy in children and adolescents with acquired immunodeficiency syndrome and its relationship with the antiretroviral therapy employed. J Pediatr (Rio J). 2009;85(4):329-34. English, Portuguese. Doi: 10.2223/ JPED.1910.
  24. Калус Андреа A., Чин Энди Дж., Олеруд Джон E. Сахарный диабет и другие эндокринные заболевания. Под ред. А.А. Кубановой, О.Л. Иванова, А.А. Кубанова, А.Н. Львова. Дерматология Фицпатрика в клинической практике: в 3 т. М.: Бином; 2012. P 1594-604. @@Calus Andrea A., Chin Andy J., Olerud John E. Diabetes mellitus and other endocrine diseases. Ed. A.A. Kubanova, O.L. Ivanov, A.A. Kubanov, A.N. L'vov. Fitzpatrick's Dermatology in Clinical Practice: in 3 volumes. M.: Binom, 2012. P 1594-604. (In Russ.).
  25. Shah I. Adverse effects of antiretroviral therapy in HIV-1 infected children. J Trop Pediatr. 2006;52(4):244-48. doi: 10.1093/tropej/ fmi086.
  26. European Summary of Product Characteristics for Ziagen, February 2007.

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