Rosacea: trigger factors and comorbidities

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Abstract

The article presents data on rosacea, a chronic relapsing inflammatory skin disease with a high prevalence among fair-skinned adults of Northern European origin. It is known that various environmental factors, endogenous factors stimulate an enhanced innate immune response and neurovascular dysregulation, while the etiopathogenesis of rosacea requires further study. The article discusses trigger factors for rosacea, including endoplasmic reticulum stress and an extended protein response; ultraviolet radiation and thermal, mechanical, nutritional, psychological and other adverse risk factors. Information on the relationship of concomitant cardiovascular, neurological diseases in rosacea is also provided.

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About the authors

Kamila R. Ayupova

Kazan State Medical Academy – Branch Campus of RMANPE

Author for correspondence.
Email: skinderma@rambler.ru
ORCID iD: 0000-0002-2179-1214
SPIN-code: 3811-5710

Applicant at the Department of Dermatovenereology and Cosmetology

Russian Federation, Kazan

L. A. Yusupovа

Kazan State Medical Academy – Branch Campus of RMANPE

Email: skinderma@rambler.ru
ORCID iD: 0000-0001-8937-2158
SPIN-code: 5743-6872
Russian Federation, Kazan

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