Experience in the treatment of orofacial granulomatosis in the form of Misher’s macrocheilitis with cyclosporine A
- Authors: Melnikova T.V.1, Burtseva N.Y.1, Milyutina M.A.1, Monakhov K.N.1, Sokolovsky E.V.1
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Affiliations:
- Pavlov University
- Issue: Vol 30, No 8 (2023)
- Pages: 139-143
- Section: Clinical case
- URL: https://journals.eco-vector.com/2073-4034/article/view/623188
- DOI: https://doi.org/10.18565/pharmateca.2023.8.139-143
- ID: 623188
Cite item
Abstract
Background. Orofacial granulomatosis (OFG) is a chronic inflammatory disease that currently includes two syndromes: Melkersson-Rosenthal syndrome and Miescher’s granulomatous cheilitis. The etiopathogenesis of the disease has not been studied enough, the metals used in the manufacture of dental implants, crowns and fillings are considered to be possible factors leading to its development.
Description of the clinical case. The article describes a case of OFG in the form of Misher’s macrocheilitis in a young female patient, which caused difficulties in diagnosis and treatment. The diagnosis was established 2.5 years after the onset of the disease; hydroxychloroquine therapy was ineffective. A good clinical effect was obtained during therapy with cyclosporine A at an initial dose of 350 mg/day (3.8 mg per kg). The patient continues the recommended treatment is under the supervision of a dermatologist of the Outpatient Department of the Clinic of Dermatovenereology of the Pavlov University.
Full Text
About the authors
Tatiana V. Melnikova
Pavlov University
Author for correspondence.
Email: tatmel2007@yandex.ru
ORCID iD: 0000-0001-9983-0327
Head of the Outpatient Department of the Clinic of Dermatovenereology
Russian Federation, St. PetersburgN. Yu. Burtseva
Pavlov University
Email: tatmel2007@yandex.ru
ORCID iD: 0000-0003-1800-1610
Russian Federation, St. Petersburg
M. A. Milyutina
Pavlov University
Email: tatmel2007@yandex.ru
ORCID iD: 0009-0001-8687-765X
Russian Federation, St. Petersburg
K. N. Monakhov
Pavlov University
Email: tatmel2007@yandex.ru
ORCID iD: 0000-0002-8211-1665
Russian Federation, St. Petersburg
E. V. Sokolovsky
Pavlov University
Email: tatmel2007@yandex.ru
ORCID iD: 0000-0001-7610-6061
SPIN-code: 6807-7137
Russian Federation, St. Petersburg
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