A clinical case of early coronary atherosclerosis complicated by acute myocardial infarction in a young man with unspecified familial hypercholesterolemia

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Abstract

Familial hypercholesterolemia (FH) is a hereditary autosomal dominant disorder characterized by elevated low-density lipoprotein (LDL) levels and decreased numbers of functioning receptors for them. A serious complication of FH is systemic atherosclerosis, which occurs in young people, and even children, who do not have risk factors for cardiovascular diseases (CVD). Untimely diagnosis, lack of specific treatment can lead to the development of premature acute myocardial infarction (AMI) and stroke, early cardiovascular death or disability of patients. The authors present a description of a case of early coronary atherosclerosis complicated by AMI in a young man 37 years old with unspecified FH.

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About the authors

Larisa V. Tarasova

I.N. Ulyanov Chuvash State University; Republican Clinical Hospital; Institute for Advanced Medical Education

Author for correspondence.
Email: tlarisagast18@mail.ru
ORCID iD: 0000-0003-1496-0689

Dr. Sci. (Med.), Associate Professor, Head of the Department of Faculty and Hospital Therapy, Professor at the Department of Public Health and Healthcare, Head of the Gastroenterology Department

Russian Federation, Cheboksary; Cheboksary; Cheboksary

Liana A. Porfiryeva

I.N. Ulyanov Chuvash State University; Republican Cardiology Dispensary

Email: krasnova-liana@mail.ru
ORCID iD: 0009-0009-0256-9704

post-graduate student, Department of Faculty and Hospital Therapy, Cardiologist at the Cardiology Department No. 4

Russian Federation, Cheboksary; Cheboksary

Olga V. Dimitrieva

I.N. Ulyanov Chuvash State University; Republican Cardiology Dispensary

Email: salgarii@mail.ru
ORCID iD: 0000-0002-7771-6141

Cand. Sci. (Med.), Associate Professor of the Department of Hospital Therapy, Cardiologist

Russian Federation, Cheboksary; Cheboksary

Nadezhda Yu. Kucherova

I.N. Ulyanov Chuvash State University; Republican Cardiology Dispensary

Email: nadezda_kan@mail.ru
ORCID iD: 0000-0002-9500-3719

post-graduate student, Department of Faculty and Hospital Therapy, Cardiologist

Russian Federation, Cheboksary; Cheboksary

References

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Supplementary files

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1. JATS XML
2. Fig. Angiogram of the coronary arteries of patient M. PBV (subtotal stenosis (arrow), with a partially washed filling defect in the lumen, distal blood flow TIMI1-11)

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