Combination of diffuse toxic goiter and connective tissue disease (clinical observation)

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Abstract

The relationship between thyroid diseases and various systemic connective tissue disorders has been known for a long time, including the association of systemic scleroderma and scleroderma-like fibrosing skin lesions with thyroid diseases. However, the literature mainly describes cases of a combination of connective tissue diseases with hypothyroidism against the background of chronic autoimmune thyroiditis. The authors describe a clinical case of associated course of diffuse toxic goiter complicated by endocrine ophthalmopathy and connective tissue disease lasting 14 years. The article discusses the difficulties of diagnosis and choice of treatment tactics for such a patient. A multidisciplinary approach to managing a patient with combined autoimmune pathology of the thyroid gland and connective tissue can increase the effectiveness of treatment and improve the long-term prognosis.

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About the authors

Lyudmila A. Sharonova

Samara State Medical University

Author for correspondence.
Email: l.a.sharonova@samsmu.ru
ORCID iD: 0000-0001-8827-4919

Cand. Sci. (Med.), Associate Professor, Department of Endocrinology and Geriatrics

Russian Federation, Samara

Svetlana V. Bulgakova

Samara State Medical University

Email: osteoporosis63@gmail.com
ORCID iD: 0000-0003-0027-1786

Dr. Sci. (Med.), Associate Professor, Head of the Department of Endocrinology and Geriatrics

Russian Federation, Samara

Olga V. Kosareva

Samara State Medical University

Email: o.v.kosareva@samsmu.ru
ORCID iD: 0009-0006-4531-9682

Cand. Sci. (Med.), Associate Professor, Department of Endocrinology and Geriatrics

Russian Federation, Samara

Yulia A. Dolgikh

Samara State Medical University

Email: yu.a.dolgikh@samsmu.ru
ORCID iD: 0000-0001-6678-6411

Cand. Sci. (Med.), Assistant Professor, Department of Endocrinology and Geriatrics

Russian Federation, Samara

Polina Ya. Merzlova

Samara State Medical University

Email: p.ya.merzlova@samsmu.ru
ORCID iD: 0009-0004-6243-6528

Assistant, Department of Endocrinology and Geriatrics

Russian Federation, Samara

Ekaterina V. Treneva

Samara State Medical University

Email: eka1006@yandex.ru
ORCID iD: 0000-0003-0097-7252

Cand. Sci. (Med.), Associate Professor, Department of Endocrinology and Geriatrics

Russian Federation, Samara

Dmitry P. Kurmaev

Samara State Medical University

Email: geriatry@mail.ru
ORCID iD: 0000-0003-4114-5233

Assistant, Department of Endocrinology and Geriatrics

Russian Federation, Samara

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