Efficiency of using domestic enteral formula with metabolic action in children with cystic fibrosis

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

Background: A consistently high level of endogenous intoxication in children with cystic fibrosis (CF) is one of the links in the pathogenesis of CF progression, the severity of clinical manifestations and the development of complications.

Objective: Evaluation of the clinical efficacy of domestic specialized enteral formulas with a metabolic action «Protein Detoxification Cocktail NUTRIO» and «Protein Detoxification Cocktail» («LEOVIT nutrio» LLC, Russia) in diet therapy for children with CF.

Materials and methods: The study included 43 patients with CF aged 3 to 17 years 11 months who were undergoing treatment and rehabilitation at the Research Clinical Institute of Childhood of the Ministry of Healthcare of the Moscow Region from September 2024 to March 2025. The patients were divided into 4 groups: the 1st main group consisted of 16 children aged 3 to 8 years, who were prescribed the domestic formula «Protein Detoxification Cocktail NUTRIO» (liquid mixture); the 2nd main group included 16 patients aged 9 to 17 years 11 months who received the domestic product «Detoxifying Protein Cocktail» (dry mixture) or «Detoxifying Protein Cocktail NUTRIO» liquid mixture (optional); the 1st control group included 5 children aged 3 to 8 years who received a formula of an imported manufacturer (liquid mixture) and the 2nd control group included 6 patients aged 9 to 17 years 9 months who received a formula of an imported manufacturer (dry mixture) for 3 months. During the follow-up, the general condition of the children, nutritional status, including anthropometry, caliperometry and bioimpedancemetry, as well as blood parameters and intoxication markers were assessed.

Results: A significant improvement in the physical development of children was shown, in whom malnutrition decreased. This was evidenced by the positive dynamics of body weight, skeletal muscle mass, Z-scores weight/length and body mass index/age, increased blood levels of total protein and albumin. In children taking domestic detox formulas, markers of intoxication significantly decreased, which was reflected in an improvement in the general condition, increased physical activity, endurance, improved quality of life and psycho-emotional state. All patients highly rated the taste of the product. There were no refusals from the product. Allergic, dyspeptic and other side effects were not noted during the follow-up period.

Discussion: The results obtained correlate well with the authors’ data on the study of clinical efficacy, safety and significant economic benefits of using domestic detox formulas.

Conclusion: The use of domestic specialized food products for dietary therapeutic and dietary preventive nutrition «Protein Detoxification Cocktail NUTRIO» and «Protein Detoxification Cocktail» in diet therapy for children with CF is effective for correcting their nutritional status, reducing intoxication and improving the quality of life.

Толық мәтін

Рұқсат жабық

Авторлар туралы

Niso Odinaeva

Research Clinical Institute of Childhood, Ministry of Healthcare of Moscow Region

Email: Julia_alina777@mail.ru
ORCID iD: 0000-0001-5214-8072

Dr. Sci. (Med.), Professor, Director

Ресей, Mytishchi

Elena Kondratieva

Research Clinical Institute of Childhood, Ministry of Healthcare of Moscow Region; Bochkov Scientific Research Center of Medical Genetics

Email: Julia_alina777@mail.ru
ORCID iD: 0000-0001-6395-0407

Dr. Sci. (Med.), Professor, Head of the Russian Cystic Fibrosis Center, Head of the Department of Respiratory Disease Genetics, Institute of Higher and Additional Professional Education, Deputy Director for Science

Ресей, Mytishchi; Moscow

Tatiana Pilat

Izmerov Research Institute of Occupational Medicine

Email: Julia_alina777@mail.ru
ORCID iD: 0000-0002-5930-8849

Dr. Sci. (Med.), Professor, Leading Researcher

Ресей, Moscow

Irina Fatkhullina

Research Clinical Institute of Childhood, Ministry of Healthcare of Moscow Region

Email: Julia_alina777@mail.ru
ORCID iD: 0000-0001-8005-5121

Head of the Cystic Fibrosis Department

Ресей, Mytishchi

Elena Zhekaite

Research Clinical Institute of Childhood, Ministry of Healthcare of Moscow Region; Bochkov Scientific Research Center of Medical Genetics

Email: Julia_alina777@mail.ru
ORCID iD: 0000-0001-5013-3360

Cand. Sci. (Med.), Senior Researcher of the Cystic Fibrosis Research and Clinical Department, Associate Professor of the Department of Respiratory Disease Genetics, Pediatrician, Cystic Fibrosis Department

Ресей, Mytishchi; Moscow

Yulia Kuznetsova

Central State Medical Academy of the Administrative Directorate of the President of the Russian Federation

Хат алмасуға жауапты Автор.
Email: Julia_alina777@mail.ru
ORCID iD: 0000-0002-0947-2333

Cand. Sci. (Med.), Assistant Professor, Department of Gastroenterology

Ресей, Moscow

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