Osobennosti remodelirovaniya levogo zheludochka i razvitiya khronicheskoy serdechnoy nedostatochnosti u bol'nykh, perenesshikh infarkt miokarda, s uchetom sposoba revaskulyarizatsii i priverzhennosti terapii


Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

The study was aimed to the evaluation of the structural and functional features of left ventricular remodeling and the development of chronic heart failure (CHF) in patients with myocardial infarction (MI) taking into account the mode of revascularization and adherence to therapy. At the hospital stage, all patients (n=101) were randomized to treatment groups according to a method of myocardial revascularization. Group 1 consisted of patients who underwent thrombolytic therapy (TLT), Group 2 - patients with percutaneous coronary intervention (PCI), the Group 3 - patients who did not undergo revascularization. At discharge from the hospital and 1 year after MI, the following examination was performed: echocardiography and Doppler echocardiography, a 6-minute walk test (6MWT), Rating Scale of Clinical State (RSCS), and evaluation of NT-proBNP levels. Adherence to the 5-component therapy (statins, two antiplatelets, renin-angiotensin-aldosterone system blockers, β-blockers) during the 1 year was assessed using Morisky-Green questionnaire. According to the results of study after one year of observation, it was revealed that PCI contributed to the improvement of the clinical manifestation, increased exercise tolerance, and had significant positive influence on echocardiography indicators, regardless of adherence to therapy. TLT therapy in acute myocardial infarction, with adherence to therapy, prevented further progression of CHF. In patients without myocardial reperfusion, signs of abnormal maladaptive left ventricular remodeling and higher NT-proBNP levels were revealed, indicating the progression of heart failure, particularly in patients without adherence to therapy.

Толық мәтін

Рұқсат жабық

Әдебиет тізімі

  1. Агеев Ф.Т., Арутюнов Г.П., Беленков Ю.Н. и др. Хроническая сердечная недостаточность. М., 2010. 336 с.
  2. McMurray J.J., Adamopoulos S., Anker S.D., Auricchio A., Böhm M., Dickstein K., Falk V., Filippatos G., Fonseca C., Gomez-Sanchez M.A., Jaarsma T., Кuber L., Lip G.Y., Maggioni A.P., Parkhomenko A., Pieske B.M., Popescu B.A., Ronnevik P.K., Rutten F.H., Schwitter J., Seferovic P., Stepinska J., Trindade P.T., Voors A.A., Zannad F., Zeiher A. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012 of the European society of cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2012 Jul;33 (14):1787-847.
  3. Никитин Н.П., Аляви А.Л., Голоскова В.Ю. Особенности процесса позднего ремоделирования у больных, перенесших инфаркт миокарда и их прогностическое значение. Кардиология. 2001;1:54-8
  4. Глезер М.Г., Семенцов Д.П., Соболев К.Э. Лечение больных инфарктом миокарда в условиях типичной клинической практики. Кардиология. 2005;45(1):21-5.
  5. Armstrong P.W., Gershlick A.H., Goldstein P., Wilcox R.,DanaysT.,Lambert Y.,Sulimov V.,Rosell Ortiz F., Ostojic M., Welsh R.C., Carvalho A.C., Nanas J., Arntz H.R., Halvorsen S., Huber K., Grajek S., Fresco C., Bluhmki E., Regelin A., Vandenberghe K., Bogaerts K., Van de Werf F. STREAM Investigative Team. Fibrinolysis or Primary PCl in ST-segment elevation Myocardial infarction. N. Engl. J. Med. 2013;368:1379-87.
  6. Фофанова Т.В., Агеев Ф.Т. Приверженность лечению в медицинской практике и возможные методы ее повышения. Кардиологический вестник. 2011;2:46-53.
  7. Национальные рекомендации ВНОК и ОССН по диагностике и лечению ХСН (четвертый пересмотр). М., 2013. 112 с.
  8. Bentzen H., Pedersen R.S., Pedersen H.B., Nyvad O., Pedersen E.B. Abnormal rhythmic oscillations of atrial natriuretic peptide and brain natriuretic peptide in heart failure. Clin.Sci. (Lond). 2003;104(3):303-24.
  9. Шрейдер Е.В., Шахнович Р.М., Руда М.Я. Клиническое значение определения натрий-уретических пептидов при остром коронарном синдроме. Терапевтический архив. 2010;9:63-70.

Қосымша файлдар

Қосымша файлдар
Әрекет
1. JATS XML
Жүктеу

© Bionika Media, 2015

Осы сайт cookie-файлдарды пайдаланады

Біздің сайтты пайдалануды жалғастыра отырып, сіз сайттың дұрыс жұмыс істеуін қамтамасыз ететін cookie файлдарын өңдеуге келісім бересіз.< / br>< / br>cookie файлдары туралы< / a>