TREATMENT OF NON-SMALL CELL LUNG CANCER: THE NEXT STEP
- Авторлар: Borisova E.B1, Gutorov S.L1, Abramov M.E1
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Мекемелер:
- Шығарылым: № 17 (2016)
- Беттер: 25-29
- Бөлім: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/289321
- ID: 289321
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Аннотация
The introduction of PD-1 inhibitors - nivolumab and pembrolizumab - into the second-line treatment of advanced non-small cell lung cancer (NSCLC) followed successful clinical trials of these drugs and was an important step in the development of treatment strategies in NSCLC. A new type of treatment showed a significant increase in objective response rate and overall survival and more favorable spectrum of complications compared to standard chemotherapy with docetaxel. The review discusses the features of assessment of the dynamics of disease manifestations during the treatment with inhibitors of the control points of the immune response, the specificity of drug toxicity, and issues of determining the PD-L1 expression requiring further development.
Негізгі сөздер
Толық мәтін
Авторлар туралы
E. Borisova
FSBI RORC n.a. N.N. Blokhin of RMH Moscow
S. Gutorov
FSBI RORC n.a. N.N. Blokhin of RMH Moscow
M. Abramov
FSBI RORC n.a. N.N. Blokhin of RMH PhD, Senior Researcher at the Department of Chemotherapy and Combined Therapy of Malignant Tumors Moscow
Әдебиет тізімі
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