Eosinophilic cellulitis as a manifestation of hypereosinophilic syndrome


Дәйексөз келтіру

Толық мәтін

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Аннотация

Hyperaosinophilic syndrome (HES) most often affects people aged 20 to 50 years and is characterized by peripheral blood eosinophilia with involvement or organ dysfunction directly caused by eosinophilia in the absence of parasitic, allergic or other causes of eosinophilia. HES is defined as peripheral blood eosinophilia >1500/ц1, lasting >6 months. The clinical picture of HES is manifested by nonspecific symptoms (malaise, anorexia, weight loss, periodic abdominal pain, night sweats, cough, myalgia, fever). Skin lesions in HES are observed in more than 50% of patients. The “standard set" of skin manifestations of HES (itchy papules and nodules, blisters, angioede-ma) is not specific, and does not promote to the early diagnosis of this disease. And only eosinophilic cellulitis (EC), associated with the debut of the HES, has its own “clinical face". EC can be the starting point of the pathogenetic process leading to a full-scale clinical and morphological picture of multisystem eosinophil-associated states - Schulman syndrome, Churg-Strauss syndrome and HES. In the treatment of EC, glucocorticosteroids, sulfones (dapsone), cyclosporine, griseofulvin, azathioprine, and Hi antihistamines are used.

Толық мәтін

Рұқсат жабық

Авторлар туралы

L. Plieva

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology

Email: doctorlina@list.ru

E. Fomina

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology

Әдебиет тізімі

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