Eosinophilic cellulitis as a manifestation of hypereosinophilic syndrome
- Авторлар: Plieva L.R1, Fomina E.S1
-
Мекемелер:
- Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology
- Шығарылым: Том 26, № 8 (2019)
- Беттер: 14-17
- Бөлім: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/312439
- DOI: https://doi.org/10.18565/pharmateca.2019.8.14-17
- ID: 312439
Дәйексөз келтіру
Аннотация
Hyperaosinophilic syndrome (HES) most often affects people aged 20 to 50 years and is characterized by peripheral blood eosinophilia with involvement or organ dysfunction directly caused by eosinophilia in the absence of parasitic, allergic or other causes of eosinophilia. HES is defined as peripheral blood eosinophilia >1500/ц1, lasting >6 months. The clinical picture of HES is manifested by nonspecific symptoms (malaise, anorexia, weight loss, periodic abdominal pain, night sweats, cough, myalgia, fever). Skin lesions in HES are observed in more than 50% of patients. The “standard set" of skin manifestations of HES (itchy papules and nodules, blisters, angioede-ma) is not specific, and does not promote to the early diagnosis of this disease. And only eosinophilic cellulitis (EC), associated with the debut of the HES, has its own “clinical face". EC can be the starting point of the pathogenetic process leading to a full-scale clinical and morphological picture of multisystem eosinophil-associated states - Schulman syndrome, Churg-Strauss syndrome and HES. In the treatment of EC, glucocorticosteroids, sulfones (dapsone), cyclosporine, griseofulvin, azathioprine, and Hi antihistamines are used.
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Авторлар туралы
L. Plieva
Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology
Email: doctorlina@list.ru
E. Fomina
Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology
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