The role of rs12976445 polymorphism in the MIR125A gene in the clinical course of diffuse toxic goiter: a retrospective clinical study


Дәйексөз келтіру

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Аннотация

Background. Over the past years, the role of microRNAs in the pathogenesis of autoimmune thyroid diseases, including diffuse toxic goiter (DTG), has been actively studied. To date, few studies on the evaluation of single-nucleotide polymorphism (SNP) rs12976445 in the MIR125A gene in patients with DTG have been conducted. Among the Russian population of patients with DTG, such study was not performed. Objective. Evaluation of the effect of rs12976445 polymorphism in the MIR125A gene on the course of DTG. Methods. We conducted a retrospective clinical study. 270 patients with DTG, residents of St. Petersburg, and 200 healthy individuals of comparison group were examined. In all patients with DTG, thyroid-stimulating hormone (TSH), free T4 (sTT4), free T3 (sTT3), and anti-TSH receptor antibody (anti-rTSH) levels were assessed. The identification of SNP rs12976445 in the MIR125A gene was carried out by polymerase chain reaction followed by restriction enzyme digest analysis. Results. The MIR125A genotype distribution and the allele frequency did not differ in patients with DTG and in the comparison group. Carriage of the SNP rs12976445 C allele in the MIR125A gene was found to be associated with an increase in the risk of thyrotoxicosis recurrence and the absence of remission of DTG by 4.5 times. Conclusion. Thus, the presented study has identified genetic markers of the adverse course of DTG.

Толық мәтін

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Авторлар туралы

Anna Volkova

Pavlov First St. Petersburg State Medical University

Email: volkovaa@mail.ru
Dr. Sci. (Med.), Professor

N. Peykrishvili

Pavlov First St. Petersburg State Medical University

Department of Faculty Therapy with Course of Endocrinology, Cardiology and Functional Diagnostics n.a. G.F. Lang with the Clinic

S. Dora

Pavlov First St. Petersburg State Medical University

Department of Faculty Therapy with Course of Endocrinology, Cardiology and Functional Diagnostics n.a. G.F. Lang with the Clinic

I. Abramova

Pavlov First St. Petersburg State Medical University

Department of Faculty Therapy with Course of Endocrinology, Cardiology and Functional Diagnostics n.a. G.F. Lang with the Clinic

G. Allamova

Pavlov First St. Petersburg State Medical University

Department of Faculty Therapy with Course of Endocrinology, Cardiology and Functional Diagnostics n.a. G.F. Lang with the Clinic

Әдебиет тізімі

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