Cicatricial alopecia: classification, clinical and morphological features, diagnosis and treatment (literature review)

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Дәйексөз келтіру

Толық мәтін

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Аннотация

Up to 8% of dermatological patients visit doctors about hair loss. Among the causes of hair loss, cicatricial alopecia (CA) represents a challenging diagnostic and therapeutic challenge. CA includes a group of diseases in which the common end result is the destruction of the hair follicle, which is replaced by connective tissue. The irreversibility of hair loss and the associated adverse cosmetic consequences of CA require special attention to their timely diagnosis. There are primary and secondary CAs. Primary CA is characterized by a folli-culocentric inflammatory process, which leads to the destruction of the hair follicle; in secondary RA, the hair follicle is indirectly affected along with other skin structures. The proportion of primary RA, which represents the greatest difficulty in diagnostic and therapeutic terms, accounts for 3–7%. Diagnosis of the disease that caused primary CA is based on a careful collection of the patient’s medical history, clinical examination, dermoscopic (trichoscopic) data and the results of a biopsy of the scalp, which is a necessary condition for prescribing appropriate therapy. The article presents literature data on the classification, diagnosis and treatment of various types of CA.

Толық мәтін

Рұқсат жабық

Авторлар туралы

R. Ravodin

Central State Medical Academy of the Administrative Department of the President of the Russian federation

Email: pharmateca@yandex.ru
ORCID iD: 0000-0002-0737-0317
Ресей, Moscow

L. Kruglova

Central State Medical Academy of the Administrative Department of the President of the Russian federation

Хат алмасуға жауапты Автор.
Email: kruglovals@mail.ru
ORCID iD: 0000-0002-5044-5265

Dr. Sci. (Med.), Professor, Head of the Department of Dermatovenereology and Cosmetology

Ресей, Moscow

E. Denisova

North-Western State Medical University n.a. I.I. Mechnikov; Volosy.ru Clinic

Email: pharmateca@yandex.ru
ORCID iD: 0009-0000-4414-0417
Ресей, St. Petersburg; St. Petersburg

Әдебиет тізімі

  1. Мильдзихова Д.Р., Мельниченко О.О., Корсунская И.М. Современные подходы к терапии андрогенетической алопеции. Клиническая дерматология и венерология. 2019;18(4):501–4. [Mildzikhova D.R., Melnichenko O.O., Korsunskaya I.M. Modern approaches to the treatment of androgenetic alopecia. Klinicheskaya dermatologiya i venerologiya. 2019;18(4):501–4. (In Russ.)].
  2. Trüeb R.M. Vernarbende Alopezien [Cicatricial alopecias]. Hautarzt. 2013;64(11):810–19. German. doi: 10.1007/s00105-013-2577-2.
  3. Pradhan P., D’Souza M., Bade B.A., et al. Psychosocial impact of cicatricial alopecias. Indian J Dermatol. 2011;56(6):684–88. doi: 10.4103/0019-5154.91829.
  4. Ross E.K., Tan E., Shapiro J. Update on primary cicatricial alopecias. J Am Acad Dermatol. 2005;53(1):1–37; quiz 38–40. doi: 10.1016/j.jaad.2004.06.015. Erratum in: J Am Acad Dermatol. 2005;53(3):496.
  5. Whiting D.A. Cicatricial alopecia: clinico-pathological findings and treatment. Clin Dermatol. 2001;19(2):211–25. doi: 10.1016/s0738-081x(00)00132-2.
  6. Rongioletti F., Christana K. Cicatricial (Scarring) Alopecias. Am J Clin. Dermatol. 2012;13(4):247–60. doi: 10.2165/11596960-000000000-00000.
  7. Somani N., Bergfeld W.F. Cicatricial alopecia: classification and histopathology. Dermatol Ther. 2008;21:221–37.
  8. Sperling L.C., Cowper S.E. The histopathology of primary cicatricial alopecia. Semin Cutan Med Surg. 2006;25:41–50.
  9. Harries M.J., Trueb R.M., Tosti A., et al. How not to get scar(r)ed: pointers to the correct diagnosis in patients with suspected primary cicatricial alopecia. Br J Dermatol 2009;160:482–501.
  10. Stefanato C.M. Histopathologic diagnosis of alopecia: clues and pitfalls in the follicular microcosmos. Diagnostic Histopathol. 2020;26(3):114–27. doi: 10.1016/j.mpdhp.2019.12.003.
  11. McElwee K.J. Etiology of cicatricial alopecias: a basic science point of view. Dermatol Ther. 2008;21:212–20.
  12. Trachsler S., Trueb R.M. Value of direct immunofluorescence for differential diagnosis of cicatricial alopecia. Dermatol. 2005;211(2):98–102. doi: 10.1159/000086436.
  13. Olsen E.A., Bergfeld W.F., Cotsarelis G., et al. Workshop on Cicatricial Alopecia. Summary of North American Hair Research Society (NAHRS)-sponsored Workshop on Cicatricial Alopecia, Duke University Medical Center, February 10 and 11, 2001. J Am Acad Dermatol. 2003;48(1):103–10. doi: 10.1067/mjd.2003.68.
  14. McElwee KJ. Etiology of cicatricial alopecias: a basic science point of view. Dermatol Ther. 2008;21(4):212–20. doi: 10.1111/j.1529-8019.2008.00202.x.
  15. Harries M.J., Meyer K.C., Chaudhry I.H., et al. R. Does collapse of immune privilege in the hair-follicle bulge play a role in the pathogenesis of primary cicatricial alopecia? Clin Exp Dermatol. 2010;35(6):637–44. doi: 10.1111/j.1365-2230.2009.03692.x.
  16. Hoang M.P., Keady M., Mahalingam M. Stem cell markers (cytokeratin 15, CD34 and nestin) in primary scarring and nonscarring alopecia. Br J Dermatol. 2009;160(3):609–15. doi: 10.1111/j.1365-2133.2008.09015.x.
  17. Karnik P., Tekeste Z., McCormick T.S., et al. Hair follicle stem cell-specific PPARgamma deletion causes scarring alopecia. J Invest Dermatol. 2009;129(5):1243–57. doi: 10.1038/jid.2008.369.
  18. Harries M.J., Paus R. Scarring alopecia and the PPAR-gamma connection. J Invest Dermatol. 2009;129(5):1066–70. doi: 10.1038/jid.2008.425.
  19. Harries M.J., Paus R. The pathogenesis of primary cicatricial alopecias. Am J Pathol. 2010;177(5):2152–62. doi: 10.2353/ajpath.2010.100454.
  20. Rosenblum M.D., Yancey K.B., Olasz E.B., Truitt R.L. CD200, a «no danger» signal for hair follicles. J Dermatol Sci. 2006;41(3):165–74. doi: 10.1016/j.jdermsci.2005.11.003.
  21. Rigopoulos D., Stamatios G., Ioannides D. Primary Scarring Alopecias. Curr Probl Dermatol. 2015:47:76–86. doi: 10.1159/000369407.
  22. Rongioletti F., De Lucchi S., Meyes D., et al. Follicular mucinosis: a clinicopathologic, histochemical, immunohistochemical and molecular study comparing the primary benign form and the mycosis fungoides associated follicular mucinosis. J Cutan Pathol. 2010;37:15–9.
  23. Romine K.A., Rothschild J.G., Hansen R.C. Cicatricial alopecia and keratosis pilaris: keratosis follicularis spinulosa decalvans. Arch Dermatol. 1997;133:381–84.
  24. Bhoyrul B. A simple technique to distinguish fibrosing alopecia in a pattern distribution from androgenetic alopecia and concomitant seborrheic dermatitis. J Am Acad Dermatol. 2022;86(1):163–65. doi: 10.1016/j.jaad.2020.12.077.
  25. Lacarrubba F., Micali G., Tosti A. Scalp dermoscopy or trichoscopy. Curr Probl Dermatol. 2015;47:21–32. doi: 10.1159/000369402.
  26. Stefanato C.M. Histopathology of alopecia: a clinicopathological approach to diagnosis. Histopathol. 2010;56(1):24–38. doi: 10.1111/j.1365-2559.2009.03439.x.
  27. Doche I., Romiti R., Hordinsky M.K., Valente N.S. «Normal-appearing» scalp areas are also affected in lichen planopilaris and frontal fibrosing alopecia: An observational histopathologic study of 40 patients. Exp Dermatol. 2020;29(3):278–81. doi: 10.1111/exd.13834.
  28. Miteva M., Tosti A. Dermoscopy guided scalp biopsy in cicatricial alopecia. J Eur. Acad Dermatol Venereol. 2013;27:1299–303.
  29. Rakowska A., Slowinska M., KowalskaOledzka E., et al. Trichoscopy of cicatricial alopecia. J Drugs Dermatol. 2012;11:753–58.
  30. Nguyen J.V., Hudacek K., Whitten J.A., et al. The HoVert technique: a novel method for the sectioning of alopecia biopsies. J Cutan Pathol. 2011;38:401.
  31. Kolivras A., Thompson C. Primary scalp alopecia: new histopathological tools, new concepts and a practical guide to diagnosis. J Cutan Pathol. 2016;44(1):53–69. doi: 10.1111/cup.12822.
  32. Zinkernagel M.S., Med C., Trueb R.M. Fibrosing alopecia in a pattern distribution. Arch Dermatol. 2000;136:205–11.
  33. Starace M., Orlando G., Alessandrini A., et al. Diffuse variants of scalp lichen planopilaris: clinical, trichoscopic, and histopathologic features of 40 patients. J.Am. Acad. Dermatol. 2020;83: 1659–67.
  34. Saceda‐Corralo D., Fernandez‐Crehuet P., Fonda‐Pascual .P, et al. Clinical description of frontal fibrosing alopecia with concomitant lichen planopilaris. Skin Appendage Disord. 2018; 4:105–7.
  35. Meinhard J., Stroux A., Lunnemann L., et al. Lichen planopilaris: epidemiology and prevalence of subtypes – a retrospective analysis in 104 patients. JDDG. 2014;12:229–35.
  36. Bolduc C., Sperling L.C., Shapiro J. Primary cicatricial alopecia: Lymphocytic primary cicatricial alopecias, including chronic cutaneous lupus erythematosus, lichen planopilaris, frontal fibrosing alopecia, and Graham-Little syndrome. J Am Acad Dermatol. 2016;75(6):1081–99. doi: 10.1016/j.jaad.2014.09.058.
  37. Svigos K., Yin L., Fried L., et al. A practical approach to the diagnosis and management of classic lichen planopilaris. Am J Clin Dermatol. 2021;22:681–92.
  38. Navarini A.A. Low‐dose excimer 308‐nm laser for treatment of lichen planopilaris. Arch Dermatol. 2011;147:1325–26.
  39. Yang C.C., Khanna T., Sallee B., et al. Tofacitinib for the treatment of lichen planopilaris: a case series. Dermatol Ther. 2018;31:e12656.
  40. Lee B., Elston D.M. The uses of naltrexone in dermatologic conditions. J Am Acad Dermatol. 2019;80:1746–52.
  41. Strazzulla L.C., Avila L., lo Sicco K., Shapiro J. Novel treatment using low-dose naltrexone for lichen planopilaris. J Drugs Dermatol. 2017;16:1140–2.
  42. Tziotzios C., Stefanato C.M., Fenton D.A., et al. Frontal fibrosing alopecia: reflections and hypotheses on aetiology and pathogenesis. Exp Dermatol. 2016;25(11):847–52. doi: 10.1111/exd.13071.
  43. Photiou L., Nixon R.L., Tam M., et al. An update of the pathogenesis of frontal fibrosing alopecia: What does the current evidence tell us? Australas. J Dermatol. 2018;60(2). doi: 10.1111/ajd.12945.
  44. Robinson G., McMichael A., Wang S.Q., et al. Sunscreen and Frontal Fibrosing Alopecia: A Review. J Am Acad Dermatol. 2019;82(3). doi: 10.1016/j.jaad.2019.09.085.
  45. Pirmez R., Duque‐Estrada B., Abraham L.S., et al. It’s not all traction: the pseudo ‘fringe sign’ in frontal fibrosing alopecia. Br J Dermatol. 2015;173:1336–38.
  46. Moreno-Arrones O.M., Saceda-Corralo D., Fonda-Pascual P., et al. Frontal fibrosing alopecia: clinical and prognostic classification. J Eur Acad Dermatol. Venereol. 2017;31:1739–45.
  47. Starace M., Orlando G., Iorizzo M., et al. Clinical and Dermoscopic Approaches to Diagnosis of Frontal Fibrosing Alopecia: Results From a Multicenter Study of the International Dermoscopy Society. Dermatol Pract Concept. 2022;12(1):e2022080. doi: 10.5826/dpc.1201a80.
  48. Kepinska K., Jałowska M., Bowszyc-Dmochowska M. Frontal Fibrosing Alopecia – a review and a practical guide for clinicians. Ann Agric Environ Med. 2022;29(2):169–84. doi: 10.26444/aaem/141324.
  49. Vano-Galvan S., Molina-Ruiz A.M., Serrano-Falcon C., et al. Frontal fibrosing alopecia: a multicenter review of 355 patients. J Am Acad Dermatol. 2014;70(4):670–78. doi: 10.1016/j.jaad.2013.12.003.
  50. Orlando G., Piraccini B.M., Starace M. The spectrum of fibrosing alopecias. JEADV. Clin Pract. 2022;1:186–95. doi: 10.1002/jvc2.50.
  51. Jerjen R., Pinczewski J., Sinclair R., Bhoyrul B. Clinicopathological characteristics and treatment outcomes of fibrosing alopecia in a pattern distribution: A retrospective cohort study. J Eur Acad Dermatol Venereol. 2021;35(1). doi: 10.1111/jdv.17604.
  52. Griggs J., Trueb R.M., Gavazzoni Dias M.F.R., et al. Fibrosing alopecia in a pattern distribution. J Am Acad Dermatol. 2021;85:1557–64.
  53. Missio D., Dias M.R.G., Trueb R. Familial cicatricial alopecia: report of familial frontal fibrosing alopecia and fibrosing alopecia in a pattern distribution. Int J Trichol. 2017;9:130–34.
  54. Ramanauskaite A., Trueb R. Facial papules in fibrosing alopecia in a pattern distribution (cicatricial pattern hair loss). Int J Trichol. 2015;7:119–22.
  55. Liu Y.S., Jee S.H., Chan J.L. Hair transplantation for the treatment of lichen planopilaris and frontal fibrosing alopecia: A report of two cases. Australas J Dermatol. 2018;59(2):e118–22. doi: 10.1111/ajd.12682.
  56. Baquerizo Nole K.L., Nusbaum B., Pinto G.M., Miteva M. Lichen planopilaris in the androgenetic alopecia area: a pitfall for hair transplantation. Skin Appendage Disord. 2015;1(01):49–53.
  57. Chiang Y.Z., Tosti A., Chaudhry I.H. Lichen planopilaris following hair transplantation and face-lift surgery. Br J Dermatol. 2012;166(03):666–370. [PubMed: 21985326].
  58. Alzolibani A.A., Kang H., Otberg N., et al. Pseudopelade of Brocq. Dermatol Ther. 2008;21:257–63.
  59. Mirmirani P., Willey A., Headington J.T., et al. Primary cicatricial alopecia: histopathologic findings do not distinguish clinical variants. J Am Acad Dermatol 2005;52:637–43.
  60. Yu M., Bell R.H., Ross E.K., et al. Lichen planopilaris and pseudopelade of Brocq involve distinct disease associated gene expression patterns by microarray. J Dermatol Sci. 2010;57:27–36.
  61. Fabbri P., Amato L., Chiarini C., et al. Scarring alopecia in discoid lupus erythematosus: a clinical, histopathologic and immunopathologic study. Lupus. 2004;13:455–62.
  62. Lopez-Tintos B.O., Garcia-Hidalgo L., Orozco-Topete R. Dermoscopy in active discoid lupus. Arch Dermatol. 2009;145:358.
  63. Hordinsky M. Cicatricial alopecia: discoid lupus erythematosus. Dermatol Ther. 2008;21:245–8.
  64. Desai K., Miteva M. Recent Insight on the Management of Lupus Erythematosus Alopecia. Clin Cosmet Investig Dermatol. 2021;14:333–47. doi: 10.2147/CCID.S269288.
  65. Trueb R.M. Involvement of scalp and nails in lupus erythematosus. Lupus. 2010;19(9):1078–86. doi: 10.1177/0961203310373938.
  66. Madura C., Vinay N., Kusuma M.R., et al. The assessment of Hair Transplantation Outcomes in Cicatricial Alopecia. Int J Trichol. 2020;12(4):164–67. doi: 10.4103/ijt.ijt_52_19.
  67. Kuhn A., Aberer E., Bata-Csorgo Z., et al. S2k guideline for treatment of cutaneous lupus erythematosus – guided by the European Dermatology Forum (EDF) in cooperation with the European Academy of Dermatology and Venereology (EADV). J Eur Acad Dermatol Venereol. 2017;31(3):389–404. Doi: 10.1111/ jdv.14053 37.
  68. Garza-Mayers A.C., McClurkin M., Smith G.P. Review of treatment for discoid lupus erythematosus. Dermatol Ther. 2016;29 (4):274–83. doi: 10.1111/dth.12358.
  69. Lyakhovitsky A., Tzanani I., Gilboa S., et al. Changing spectrum of hair and scalp disorders over the last decade in a tertiary medical centre. J Eur Acad Dermatol. Venereol. 2023;37(1):184–93. doi: 10.1111/jdv.18570.
  70. Sarkis A., de Almeida R.F.C., Lemes L.R., et al. Folliculitis Decalvans in women: a retrospective multicenter study of 150 patients. J Eur Acad Dermatol Venereol. 2023 Aug 18. doi: 10.1111/jdv.19434.
  71. Moreno-Arrones O.M., Garcia-Hoz C., Del Campo R., et al. Folliculitis Decalvans Has a Heterogeneous Microbiological Signature and Impaired Immunological Response. Dermatol. 2023;239(3):454–61. doi: 10.1159/000529301.
  72. Otberg N., Kang H., Alzolibani A., et al. Folliculitis decalvans. Dermatol Ther. 2008;21:238–44.
  73. Uchiyama M., Harada K., Tobita R., et al. Histopathologic and dermoscopic features of 42 cases of folliculitis decalvans: a case series. J Am Acad Dermatol. 2021;85(5):1185–89.
  74. Egger A., Stojadinovic O., Miteva M. Folliculitis decalvans and lichen planopilaris phenotypic spectrum: a series of 7 new cases with focus on histopathology. Am J Dermatopathol. 2020;42(3):173–77.
  75. Yang, L., Chen, J., Tong, X., et al. Photodynamic therapy should be considered for the treatment of folliculitis decalvans. Photodiagnos. Photodynam Ther. 2021;35:102356. doi: 10.1016/j.pdpdt.2021.102356.
  76. Tosti A., Torres F., Miteva M. Dermoscopy of Early Dissecting Cellulitis of the Scalp Simulates Alopecia Areata. Actas Dermo-Sifiliograficas (English Edition). 2013;104(1):92–3. doi: 10.1016/j.adengl.2012.05.022.
  77. May Lee M., Naldi L., Piraccini B.M., et al. Trichoscopy as a Tool to Evaluate Early Dissecting Cellulitis in Patients Affected by Hidradenitis Suppurativa: A Prospective Monocentric Observational Study. Skin Appendage Disord. 2023;9(4):275–79. doi: 10.1159/000530630.
  78. Nussbaum D., Desai S., Nelson K., et al. An Up-to-Date Approach to the Management of Dissecting Cellulitis. J. Drugs Dermatol. 2022;21(7):800–2. doi: 10.36849/JDD.0421.
  79. Unger W., Unger R., Wesley C. The surgical treatment of cicatricial alopecia. Dermatol Ther. 2008;21(4):295–311. doi: 10.1111/j.1529-8019.2008.00211.x.
  80. Epstein J.S. Hair transplantation in women: treating female pattern baldness and repairing distortion and scarring from prior cosmetic surgery. Arch Facial Plast Surg. 2003;5(1):121–26. doi: 10.1001/archfaci.5.1.121.
  81. Ross E.K., Shapiro J. Management of hair loss. Dermatol Clin. 2005;23(2):227–43. doi: 10.1016/j.det.2004.09.008.
  82. Dahdah M.J., Iorizzo M. The Role of Hair Restoration Surgery in Primary Cicatricial Alopecia. Skin Appendage Disord. 2016;2(1–2):57–60. doi: 10.1159/000448104.
  83. Iorizzo M., Tosti A. Frontal Fibrosing Alopecia: An Update on Pathogenesis, Diagnosis, and Treatment. Am J Clin Dermatol. 2019;20(5 Suppl. 1):1–12. doi: 10.1007/s40257-01900424-y.
  84. Singh S., Muthuvel K. Role of Hair Transplantation in Scarring Alopecia-To Do or Not to Do. Indian J Plast Surg. 2021;54(4):501–6. doi: 10.1055/s-0041-1739246.
  85. Ekelem C., Pham C., Atanaskova Mesinkovska N. A Systematic Review of the Outcome of Hair Transplantation in Primary Scarring Alopecia. Skin Appendage Disord. 2019;5(2):65–71. doi: 10.1159/000492539.
  86. Issa N.T., Tosti A. Trichoscopy for the Hair Transplant Surgeon-Assessing for Mimickers of Androgenetic Alopecia and Preoperative Evaluation of Donor Site Area. Indian J Plast Surg. 2021;54(4):393–98. doi: 10.1055/s-00411739245

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