Epidemiological characteristics of respiratory infections during the last autumn-winter season of the COVID-19 pandemic according to data from a repurposed children’s hospital

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

Background. During the end of the coronavirus pandemic, an increase in the frequency of acute respiratory viral infections (ARVI)-related hospitalizations of children and changes in the seasonality parameters of certain nosological forms were observed throughout the world.

Objective. Presentation of the epidemiological characteristics of ARVI in children hospitalized in a repurposed children’s hospital in the autumn-winter season of 2022–2023.

Methods. All children hospitalized with signs of acute respiratory tract infections during the repurposing of departments of the St. Vladimir Children’s City Clinical Hospital were subjected to rapid tests for COVID-19, influenza types A and B, and nasal and oropharyngeal swabs were taken for real-time polymerase chain reaction for SARS-CoV-2 and the spectrum of ARVI pathogens. When indicated, as part of differential diagnosis, detection of DNA of Human herpes virus 6, Epstein-Barr Virus (EBV) and Bordetella pertussis, and bacteriological studies were performed. The survey results were assessed retrospectively.

Results. During the conversion period, 2,105 patients were hospitalized. COVID-19 was diagnosed in 32 (1.5%). The diagnosis of influenza was established in 603 (28.6%) children. Respiratory syncytial virus infection (RSVI) was confirmed in 139 (6.6%) cases. Rhinovirus RNA was detected in 54 (2.6%) children. The detection rate of other identifiable respiratory viruses did not exceed 1.5%. 48.4% of disease cases remained etiologically undeciphered.

Conclusion. Influenza virus and respiratory syncytial virus were the most common pathogens detected in the study group of hospitalized patients. The data confirmed an earlier rise and an earlier winter peak for influenza in the 2022-2023 season, as well as a longer period of influenza prevalence. The traditional spring peak of RSVI incidence has also been shifted to the autumn-winter period. The mass of children sick with ARVI in the last pandemic autumn-winter season was associated with an increase in the number of hospitalization. The epidemiological characteristics of the last pandemic season are explained by the consequences of the COVID-19 pandemic, which had an impact on interviral interactions and the state of immunity of children with increased susceptibility to respiratory viruses after a long period of quarantine measures.

Толық мәтін

Рұқсат жабық

Авторлар туралы

O. Zaytseva

Russian University of Medicine

Email: tepec@yandex.ru
ORCID iD: 0000-0003-3426-3426
Ресей, Moscow

Evgenia Tolstova

Russian University of Medicine

Хат алмасуға жауапты Автор.
Email: tepec@yandex.ru
ORCID iD: 0000-0001-8340-3064

Cand. Sci. (Med.), Associate Professor at the Department of Pediatrics

Ресей, Moscow

N. Zaitseva

Russian University of Medicine

Email: tepec@yandex.ru
ORCID iD: 0000-0003-1868-1396
Ресей, Moscow

E. Lokshina

Russian University of Medicine

Email: tepec@yandex.ru
ORCID iD: 0000-0001-6006-7846
Ресей, Moscow

T. Abaseeva

Russian University of Medicine

Email: tepec@yandex.ru
ORCID iD: 0000-0002-7175-5633
Ресей, Moscow

N. Bagirova

Russian University of Medicine

Email: tepec@yandex.ru
ORCID iD: 0009-0001-3920-2430
Ресей, Moscow

S. Bardenikova

Russian University of Medicine

Email: tepec@yandex.ru
ORCID iD: 0000-0002-3428-0843
Ресей, Moscow

N. Bogdanova

Russian University of Medicine

Email: tepec@yandex.ru
ORCID iD: 0000-0002-8833-9134
Ресей, Moscow

G. Kuznetsov

Russian University of Medicine

Email: tepec@yandex.ru
ORCID iD: 0000-0002-8529-1518
Ресей, Moscow

S. Mstislavskaya

Russian University of Medicine

Email: tepec@yandex.ru
ORCID iD: 0000-0002-1912-7445
Ресей, Moscow

I. Ostroukhova

Russian University of Medicine

Email: tepec@yandex.ru
ORCID iD: 0000-0002-5503-9792
Ресей, Moscow

T. Rychkova

Russian University of Medicine

Email: tepec@yandex.ru
ORCID iD: 0000-0002-9163-2390
Ресей, Moscow

N. Serebrovskaya

Russian University of Medicine

Email: tepec@yandex.ru
ORCID iD: 0000-0002-6278-9508
Ресей, Moscow

E. Striga

Russian University of Medicine

Email: tepec@yandex.ru
ORCID iD: 0000-0002-1220-0320
Ресей, Moscow

L. Shavlokhova

Russian University of Medicine

Email: tepec@yandex.ru
ORCID iD: 0009-0007-5914-987X
Ресей, Moscow

N. Shironina

Russian University of Medicine

Email: tepec@yandex.ru
ORCID iD: 0009-0009-0194-2976
Ресей, Moscow

M. Nikonova

Russian University of Medicine

Email: tepec@yandex.ru
ORCID iD: 0009-0006-2623-1626
Ресей, Moscow

S. Kuzina

Russian University of Medicine

Email: tepec@yandex.ru
ORCID iD: 0000-0002-8565-266X
Ресей, Moscow

E. Efimova

St. Vladimir Children’s City Clinical Hospital

Email: tepec@yandex.ru
ORCID iD: 0000-0001-7874-6679
Ресей, Moscow

T. Belyaeva

St. Vladimir Children’s City Clinical Hospital

Email: tepec@yandex.ru
ORCID iD: 0000-0002-5277-9808
Ресей, Moscow

Әдебиет тізімі

  1. GBD. Mortality, morbidity, and hospitalisations due to influenza lower respiratory tract infections, 2017: an analysis for the Global Burden of Disease Study 2017. Lancet Respir Med. 2019;7:69–89. doi: 10.1016/S2213-2600(18)30496-X.
  2. Song W., Yang Y., Huang Y., et al. Acute respiratory infections in children, before and after the COVID-19 pandemic, a sentinel study. J Infect. 2022;85(1):90–122. doi: 10.1016/j.jinf.2022.04.006.
  3. Nenna R., Matera L., Licari A., et al.; ICHRIS Group. An Italian Multicenter Study on the Epidemiology of Respiratory Syncytial Virus During SARS-CoV-2 Pandemic in Hospitalized Children. Front Pediatr. 2022;10:930281. doi: 10.3389/fped.2022.930281.
  4. Государственный доклад о состоянии санитарно-эпидемиологического благополучия населения Российской Федерации в 2022 г. (оперативная информация БУЗ ФЦГиЭ Роспотребнадзора). [State report on the state of sanitary and epidemiological well-being of the population of the Russian Federation in 2022 (operational information from the Federal Center for Hygiene and Epidemiology of Rospotrebnadzor). (In Russ.)]. URL: https://www.rospotrebnadzor.ru/upload/iblock/b50/t4kqksh4b12a2iwjnha29922vu7naki5/GD-SEB.pdf
  5. Zhu Y., Li W., Yang B., et al. Epidemiological and virological characteristics of respiratory tract infections in children during COVID-19 outbreak. BMC Pediatr. 2021;21:195. doi: 10.1186/s12887-021-02654-8.
  6. Buchholz U., Lehfeld A.S., Tolksdorf K., et al. Respiratory infections in children and adolescents in Germany during the COVID-19 pandemic. J Health Monit. 2023;8(2):20–38. doi: 10.25646/11437.
  7. Kang M., Sarkar S., Angurana S.K., et al. Paradigm shift of respiratory viruses causing lower respiratory tract infection in children during COVID-19 pandemic in India. J Infect Dev Ctries. 2023;17(7):961–70. doi: 10.3855/jidc.17727.
  8. Wang P., Xu Y., Su Z., Xie C. Impact of COVID-19 pandemic on influenza virus prevalence in children in Sichuan, China. J Med Virol. 2023;95(1):e28204. doi: 10.1002/jmv.28204.
  9. Kurskaya O.G., Prokopyeva E.A., Sobolev I.A., et al. Changes in the Etiology of Acute Respiratory Infections among Children in Novosibirsk, between 2019 and 2022: The Impact of the SARS-CoV-2 Virus. Viruses. 2023;15(4):934. doi: 10.3390/v15040934.
  10. Mellou K., Tryfinopoulou K., Emmanouil M., et al. Influenza transmission during COVID-19 measures downscaling in Greece, August 2022: evidence for the need of continuous integrated surveillance of respiratory viruses. Eurosurveill. 2023;28(28):2200754. doi: 10.2807/1560-7917.ES.2023.28.28.2200754.
  11. Ang H.J., Menegale F., Preziosi G., et al. Reconstructing the impact of COVID-19 on the immunity gap and transmission of respiratory syncytial virus in Lombardy, Italy. EBioMedicine. 2023;95:104745. doi: 10.1016/j.ebiom.2023.104745.
  12. Nam E.J., Kim D.J., Ham J.Y., et al. Recent Changes in the Human Metapneumovirus Outbreak at a University Hospital in Korea. Clin Lab. 2023;69(8). doi: 10.7754/Clin.Lab.2023.230216.
  13. Burrell R., Saravanos G., Britton P.N. Unintended impacts of COVID-19 on the epidemiology and burden of paediatric respiratory infections. Paediatr Respir Rev. 2023 Aug 3:S1526-0542(23)00044-1. doi: 10.1016/j.prrv.2023.07.004.
  14. Temsah M.H., Barry M., Memish Z.A., Al-Tawfiq J.A. Celebrating the 2023 New Year at the time of the tridemic shadow. New Microbes. New Infect. 2023;51:101081. doi: 10.1016/j.nmni.2022.101081.
  15. Kissling E., Maurel M., Emborg H.D., et al.; European IVE group; Members of the European IVE group. Interim 2022/23 influenza vaccine effectiveness: six European studies, October 2022 to January 2023. Eurosurveill. 2023;28(21):2300116. doi: 10.2807/1560-7917.ES.2023.28.21.2300116.
  16. Hoy G., Maier H.E., Kuan G., et al. Increased influenza severity in children in the wake of SARS-CoV-2. Influenza Other Respir. Viruses. 2023;17(7):e13178. doi: 10.1111/irv.13178.
  17. Obando-Pacheco P., Justicia-Grande A.J., Rivero-Calle I., et al. Respiratory Syncytial Virus Seasonality: A Global Overview. J Infect Dis. 2018;217(9):1356–64. doi: 10.1093/infdis/jiy056.
  18. Баранов А.А., Намазова-Баранова Л.С., Давыдова И.В. и др. Федеральные клинические рекомендации по иммунопрофилактике респираторно-синцитиальной вирусной инфекции у детей. Педиатрическая фармакология. 2015;12(5):543–49. [Baranov A.A., Namazova-Baranova L.S., Davydova I.V. and others. Federal clinical recommendations for immunoprophylaxis of respiratory syncytial virus infection in children. Pediatricheskaya farmakologiya. 2015;12(5):543–49. (In Russ.)]. doi: 10.15690/pf.v12i5.1456.
  19. Hamid S., Winn A., Parikh R., et al. Seasonality of Respiratory Syncytial Virus - United States, 2017-2023. MMWR. Morb Mortal Wkly Rep 2023;72(14):355–61. doi: 10.15585/mmwr.mm7214a1.
  20. Halasa N., Zambrano L.D., Amarin J.Z., et al.; RSV-PIC Investigators. Infants Admitted to US Intensive Care Units for RSV Infection During the 2022 Seasonal Peak. JAMA Netw Open. 2023;6(8):e2328950. doi: 10.1001/jamanetworkopen.2023.28950.
  21. Redlberger-Fritz M., Springer D.N., Aberle S.W., et al. Respiratory syncytial virus surge in 2022 caused by lineages already present before the COVID-19 pandemic. J Med Virol. 2023;95(6):e28830. doi: 10.1002/jmv.28830.
  22. Клинические рекомендации. Внебольничная пневмония у детей. 2022. [Clinical recommendations. Community-acquired pneumonia in children. 2022. (In Russ.)].
  23. Таточенко В.К. Внебольничные пневмонии у детей – проблемы и решения. Российский вестник перинатологии и педиатрии. 2021;1:9–21. [Tatochenko V.K. Community-acquired pneumonia in children – problems and solutions. Rossiiskiy vestnik perinatologii i pediatrii. 2021;1:9–21. (In Russ.)].
  24. Wang S., Wang X.F., Li N., et al. Distribution of non-bacterial pathogens in 1 788 children with community-acquired pneumonia. Zhongguo Dang Dai Er Ke Za Zhi. 2023;25(6):633–38. Chinese. doi: 10.7499/j.issn.1008-8830.2212079.
  25. Sura T., Gering V., Cammann C., et al. Streptococcus pneumonia and Influenza A Virus Co-Infection Induces Altered Polyubiquitination in A549 Cells. Front Cell Infect Microbiol. 2022;12:817532. doi: 10.3389/fcimb.2022.817532.
  26. Jefferson T., Dooley L., Ferroni E., et al. Physical interventions to interrupt or reduce the spread of respiratory viruses. Cochrane Database Syst Rev. 2023;1(1):CD006207. doi: 10.1002/14651858.CD006207.pub6.
  27. Principi N., Autore G., Ramundo G., Esposito S. Epidemiology of Respiratory Infections during the COVID-19 Pandemic. Viruses. 2023;15(5):1160. doi: 10.3390/v15051160.
  28. Leung N.H.L. Transmissibility and transmission of respiratory viruses. Nat Rev Microbiol. 2021;19:528–45.
  29. Liang W., Lv H., Chen C., et al. Lack of neutralizing antibodies against influenza A viruses in adults during the 2022/2023 winter season – a serological study using retrospective samples collected in Hong Kong. Int J Infect Dis. 2023;135:1–4. doi: 10.1016/j.ijid.2023.07.008.
  30. Hernandez-Rivas L., Pedraz T., Calvo C., et al. Respiratory syncytial virus outbreak during the COVID-19 pandemic. How has it changed? Enferm. Infect Microbiol Clin. 2023;41(6):352–55. doi: 10.1016/j.eimc.2021.12.003.
  31. Chuang, Y.C., Lin, K.P., Wang, L.A., et al. The Impact of the COVID-19 Pandemic on Respiratory Syncytial Virus Infection: A Narrative Review. Infect. Drug Resist. 2023;16:661–75.
  32. Dee K., Schultz V., Haney J., et al. Influenza A and respiratory syncytial virus trigger a cellular response that blocks severe acute respiratory syndrome virus 2 infection in the respiratory tract. J Infect Dis. 2022, jiac494.
  33. Fine S.R., Bazzi L.A., Callear A.P., et al. Respiratory virus circulation during the first year of the COVID-19 pandemic in the Household Influenza Vaccine Evaluation (HIVE) cohort. Influ Other Respir Viruses. 2023;17:e13106.
  34. Prazuck T., Bechet S., Lesne F., et al. Diagnostic accuracy of a rapid antigen triple test (SARS-CoV-2, respiratory syncytial virus, and influenza) using anterior nasal swabs versus multiplex RT-PCR in children in an emergency department. Infect Dis Now. 2023 Aug 10:104769. doi: 10.1016/j.idnow.2023.104769.

Қосымша файлдар

Қосымша файлдар
Әрекет
1. JATS XML
Жүктеу
2. Fig.1

Жүктеу (72KB)
Метадеректер
3. Fig.2

Жүктеу (78KB)
Метадеректер
4. Fig.3

Жүктеу (64KB)
Метадеректер

© Bionika Media, 2024

Осы сайт cookie-файлдарды пайдаланады

Біздің сайтты пайдалануды жалғастыра отырып, сіз сайттың дұрыс жұмыс істеуін қамтамасыз ететін cookie файлдарын өңдеуге келісім бересіз.< / br>< / br>cookie файлдары туралы< / a>