DIABETIChESKAYa PERIFERIChESKAYa POLINEVROPATIYa: SOVREMENNYE PREDSTAVLENIYa O PATOGENEZE I PODKhODY K TERAPII
- Autores: Komelyagina EY.1, Antsiferov MB1
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Afiliações:
- Edição: Nº 17 (2009)
- Páginas: 22-29
- Seção: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/278087
- ID: 278087
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Texto integral
Resumo
Диабетическая периферическая невропатия (ДПН) является ведущей причиной нетравматических ампутаций нижних конечностей. Рассматривается роль гипергликемии на развитие микрососудистых осложнений сахарного диабета, включая ДПН, обсуждаются механизмы повреждения тканей вследствие гипергликемии. Представлены данные о клинической картине и принципах диагностики ДПН, а также современных подходах к лечению этого диабетического осложнения с использованием симптоматических и патогенетических средств. К числу последних относятся, в частности, тиоктовая кислота и бенфотиамин.
Bibliografia
- Tornalley PJ, Kempler P. Complications of Diabetes Mellitus: Pathophysiology and Pathogenetically-based Treatment Options. International Expert Workshop 2008:1.
- Brownlee M. The pathobiology of diabetic complications. A unifying mechanism. Diabetes 2005;54:1615-25.
- Greene DA, Chakrabarti S, et al. Role of sorbitol accumulation and myoinositol depletion in paranodal swelling of large myelinated nerve fibers in the insulin-deficient spontaneously diabetic biobreeding rat. J Clin Invest 1987;79:1479-85.
- Mayer JH, Tomlinson DR. Prevention of defects of axonal transport and nerve conduction velocity by oral administration of myo-inositol or an ARI in streptozotocin diabetic rats. Diabetologia 1983;25:433-38.
- Brismar T, Sima AA. Changes in nodal function in nerve fibers of the spontaneously diabetic BB-Wistar rat. Potential clamp analysis. Acta Physiol Scand 1981;113:499-506.
- Tornalley PJ. Glyoxalase I, Structure, function, and a critical role in the enzymatic defence against glycation. Biochem Soc Trans 2003;31:1343-48.
- Ihnat MA, Thorpe JE. The "metabolic memory", the new challenge of diabetes. Diabetic Medicine 2007;24:582-86.
- Shaw JE, Zimmet PZ, Gries FA, et al. Epidemiology of Diabetic Neuropathy. In: Textbook of Diabetic Neuropathy, Thieme 2002:67.
- Dyck PJ, Litchy WJ, et al. Variables influences neuropathic endpoints. The Rochester Diabetic Neuropathy Study of Health Subjects. Neurology 1995;45:1115-21.
- International guidelines on the out-patient management of diabetic peripheral neuropathy, 1996.
- Scott J., Huskisson E.C. Graphic representation of pain. Pain 1976;2:175-84.
- Практическое руководство по ведению и профилактике диабетической стопы. М., 2000. С. 13.
- Tesfaye S, Chaturvedi N, et al. Cardiovascular risk factors predict the development of diabetic peripheral neuropathy. Diabetes 2000;49(Suppl. 1):A34.
- Bril V. Electrophysiologic testing. In: Textbook of Diabetic Neuropathy, Thieme 2002:177-184.
- Spruce MC, Potter DV, et al. The pathogenesis and management of painful diabetic neuropathy: a review. Diabetic Medicine 2003;20(2):88-99.
- Ziegler D. Treatment of neuropathic pain. In: Textbook of Diabetic Neuropathy, Thieme 2002:211-24.
- Sindrup SH, Gram LF, et al. The selective serotonin reuptake inhibitor paroxetine is effective in the treatment of diabetic neuropathy symptoms. Pain 1990;42:135-44.
- Sindrup SH, Bjerre U, et al. The selective serotonin reuptake inhibitor citalopram relieves the symptoms of diabetic neuropathy. Clin Pharmacol Ther 1992;52:547-52.
- Max MB, Lynch SA, Muir J, et al. Effects of desipramine, amitriptilline, and fluoxetine an pain in diabetic neuropathy. N Engl J Med 1992;326:1250-56.
- Thomas PK. Painful diabetic neuropathy: mechanisms and treatment. Diabetes Nutr Metab 1994;7:359-68.
- Low PA, Opfer-Gehrking TL, et al. Double-blind, placebo-controlled study of the application of capsaicin cream in chronic distal painful polyneuropathy. Pain 1995;62:163-68.
- Berrone E, Beltramo E, et al. Regulation of intracellular glucose and polyol pathway by thiamine and benfothiamine in vascular cells cultured in high glucose. J Biol Chem 2006;14:9307-13.
- Haupt E, Ledermann H, et al. Benfotiamine in the treatment of diabetic polyneuropathy - a three week randomized controlled pilot-study (BEDIP study). Int Clin Pharmacol Ther 2005;43:71-77.
- Stracke H, Gaus W. Benfotiamine in Diabetic Polyneuropathy (BENDIP): Results of randomized, double-blind, placebo-controlled clinical study. Exp Clin Endocrinol Diabetes 2008;116:600-05.
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