CHANGE OF CONGENITAL IMMUNITY FACTORS IN CHILDREN WITH CYSTIC FIBROSIS

The aim of the study was to determine the key factors of innate immunity in the 118 children with cystic fibrosis. In patients with CF identified pronounced changes in the indices of innate immunity, both in serum and at the level of the mucous membrane. In chronic sowing of the bronchial tree, Pseudomonas aeruginosa and/or Staphylococcus aureus levels of bactericidal and lysozyme activity of blood serum, C5a component of complement can be considered as markers of inflammation and provide additional laboratory diagnostic criteria of bronchopulmonary phase of the process. In acute bronchopulmonary process in children with Burkholderia cepacia observed anergy factors of innate immunity, which dramatically increases the risk of septic complications.

cystic fibrosis, children, lysozyme, complement, innate immunity