Osobennosti sistemy gemostaza u novorozhdennykh, materi kotorykh poluchali protivoepilepticheskie preparaty


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Resumo

The study was aimed to evaluation of frequency of thrombohemorrhagic complications and features of hemostatic parameters in newborns whose mothers received antiepileptic drugs during pregnancy. The study included 187 infants. Valproic acid and carbamazepine were most common drugs taken by pregnant women. Hemostatic parameters were examined in umbilical cord blood from 16 full-term newborns. Control group consisted of 11 full-term newborns of mothers without epilepsy not receiving antiepileptic drugs during pregnancy. According to clinical observation, there were no thrombohemorrhagic complications in all 187 cases. The examination of indicators of hemostasis in the treatment group and control group showed a proportional decrease in procoagulants and physiological anticoagulants, as well as raising of von Willebrand factor. Overall, the hemostatic parameters did not differ significantly in the study group and control group and were within the limits of healthy full-term infants.

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Bibliografia

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