BONE METABOLISM AND EFFECTIVENESS OF ZOLEDRONIC ACID IN LOCALLY ADVANCED AND DISSEMINATED PROSTATE CANCER


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The article considers a bone metabolism in patients with different variants of prostate cancer (PC), and its changes against the background of hormonal therapy and treatment with zoledronic acid. For this purpose, 104 patients with locally advanced PC and 85 with disseminated prostate cancer were screened for markers of bone metabolism: osteocalcin and β-cross-laps. It was noted that the progression of metastatic prostate cancer is associated with the activity of bone resorption. Reduction of bone resorption against the background of treatment with zoledronic acid in patients with locally advanced prostate cancer led to increases in bone mineral density during 12-months follow-up. Tendency to reduce the risk of bone metastasis is another result of use of zoledronic acid.

Bibliografia

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