BONE METABOLISM AND EFFECTIVENESS OF ZOLEDRONIC ACID IN LOCALLY ADVANCED AND DISSEMINATED PROSTATE CANCER


Cite item

Full Text

Abstract

The article considers a bone metabolism in patients with different variants of prostate cancer (PC), and its changes against the background of hormonal therapy and treatment with zoledronic acid. For this purpose, 104 patients with locally advanced PC and 85 with disseminated prostate cancer were screened for markers of bone metabolism: osteocalcin and β-cross-laps. It was noted that the progression of metastatic prostate cancer is associated with the activity of bone resorption. Reduction of bone resorption against the background of treatment with zoledronic acid in patients with locally advanced prostate cancer led to increases in bone mineral density during 12-months follow-up. Tendency to reduce the risk of bone metastasis is another result of use of zoledronic acid.

References

  1. Bruder JM, Ma JZ, Basler JW, et al. Prevalence of osteopenia and osteoporosis by central and peripheral bone mineral density in men with prostate cancer during androgen-deprivation therapy. Urology 2006;67(1):152-55.
  2. Preston DM, Torrens JI, Harding P, et al. Androgen deprivation in men with prostate cancer is associated with an increased rate of bone loss. Prostate Cancer Prostatic Dis 2002;5(4):304-10.
  3. Моисеенко, В.И. Паллиативное лечение больных солидными опухолями с метастатическим поражением костей В. И. Моисеенко. Лекции по фундаментальной и клинической онкологии / Под ред. В.И. Моисеенко, А.Ф. Урманчеевой, К.П. Хансона. СПб., 2004.
  4. Orwoll ES, Klein RF. Osteoporosis in men. Endocr Rev 1995;16(1):87-116.
  5. Eastham JA. Bone health in men receiving androgen deprivation therapy for prostate cancer. J Urol 2007;177(1):17-24.
  6. Percival RC, Urwin GH, Harris S, et al. Biochemical and histological evidence that carcinoma of the prostate is associated with increased bone resorption. Eur J Surg Oncol 1987;13(1):41-49.
  7. Clarke NW, McClure J, George NJ. Morphometric evidence for bone resorption and replacement in prostate cancer. Br J Urol 1991;68(1):74-80.
  8. Oefelein MG, Ricchiuti V, Conrad W, et al. Skeletal fractures negatively correlate with overall survival in men with prostate cancer. J Urol 2002;168(3):1005-07.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2011 Bionika Media

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies