PANTOPRAZOLE (CONTROLOC) IN THE PREVENTION AND TREATMENT OF ULCERATIONS OF UPPER GASTROINTESTINAL TRACT ASSOCIATED WITH USE OF ULCEROGENIC MEDICATIONS

As exemplified by pantoprazole (Controloc), the article presents data on the characteristics of the acid inhibitory mechanism of action of modern drugs commonly used for treatment and prevention of symptomatic ulcers in the upper gastrointestinal tract in patients receiving drugs with ulcerogenic action. Data from randomized trials on the intensity and duration of reduction of gastric acid production in patients receiving pantoprazole, the nature and extent of drug-drug interactions and metabolic effects on the cytochrome P450 system are discussed. It is concluded that pantoprazole can be used as first-line drug therapy in the treatment of NSAIDs-induced lesions of the upper gastrointestinal tract.

ulcerogenic medications, nonsteroidal anti-inflammatory drugs, proton pump inhibitors, pantoprazole