Combined treatment of colorectal cancer patients with liver metastases
- Autores: Polyakov A.N1, Podluzhnyy D.V1, Mamontov K.G1, Borodin D.G1, Patyutko Y.I1
-
Afiliações:
- Edição: Nº 18 (2012)
- Páginas: 42-50
- Seção: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/279999
- ID: 279999
Citar
Texto integral
Acesso aberto
Acesso está concedido
Acesso é pago ou somente para assinantes
Resumo
From 1990 to 2008, in the Department of Surgery of Tumors of the Liver and Pancreas FSBI “ROSC named after N.N. Blokhin RAMS”, 527l iver resections of various sizes for metastases of colon cancer were performed; 41 of them were re-resection. 356 patients received postoperative chemotherapy: 137 patients received the adjuvant treatment with combination of fluorouracil and leucovorin, 193 - with combination of oxaliplatin, fluorouracil and leucovorin (FOLFOX). The remaining 26 patients underwent another chemotherapy. Liver resection in combination with perioperative regional FOLFOX chemotherapy ± bevacizumab was performed in 106 cases. The study showed the feasibility and effectiveness of adjuvant chemotherapy after liver resection for metastases of colorectal cancer. Adding oxaliplatin to postoperative chemotherapy has improved the results of combined treatment. The use of bevacizumab improves the efficacy of regional neoadjuvant therapy without significant improvement of long-term results.
Texto integral
Bibliografia
- Давыдов М.И., Аксель Е.М. Статистика злокачественных новообразований в России 2005; 16(3):481 -88.doi: 10.1093/annonc/ mdi098. Accessed 5.16.07.
- American Cancer Society. Detailed Guide: Colon and rectum cancer. Available at: http:// www.cancer.org/docroot/CRI/content/ CRI_2_4_1X_What_are_the_key_statistics_ for_colon_and_rectum_cancer.asp?sitearea=. Accessed 4.23, 2007.
- Laweus D.I. Taylor. Chemotherapy for colorectal cancer - an overview of current managements for surgeons. EJSO 2005.
- deGaramont A., Boni C., Navarro M., et al. Oxaliplatin/5FU/LV in the adjuvant treatment of stage II and stage III colon cancer: efficacy results with a median follow-up of 4 years. In: Proceedings of the 2005. Gastrointestinal Cancers Symposium, 2005:167.
- Abdalla E.K., Adam R., et al. Improving Respectability of Hepatic Colorectal Metastases: Expert Consensus Statement. Ann Surg Oncol, 2006.
- Clavien P.-A., Petrowsky H., et al. Strategies for Safer Liver Surgery and Partial Liver Transplantation. N Engl J Med 2007.
- Патютко Ю.И. Хирургическое лечение злокачественных опухолей печени. Практическая медицина. М., 2005.
- Thierre A., Corrado B., Matilde N., et al. Improved Overall Survival With Oxaliplatin, Fluorouracil, and Leucovorin As Adjuvant Treatment in Stage II and III Colon Cancerin the MOSAIC Trial. J Clin Oncol 2009;27:3109-16.
- Kuebler J.P., Wieand H.S., O'Conell M.J., at al. Oxaliplatin Combined With Weekly Bolus Fluorouracil and Leucovorin As Surgical Adjuvant Chemotherapy for Stage II and III Colon Cancer: Results From NSABP C-07. J Clin Oncol 2007;25:2198-204.
- Saltz L.B., Niedzwiecki D., Hollis D., et al. Irinotecan plus fluorouracil/leucovorin (IFL) versus fluorouracil/leucovorin alone (FL) in stage III colon cancer (intergroup trial CALGB C89803). J Clin Oncol 2004;22:3500.
- Portier G., Elias D., et al. Multicenter Randomized Trial of Adjuvant Fluorouracil and Folinic Acid Compared With Surgery Alone After Resection of Colorectal Liver Metastases. FFCD ACHBTH AURC 9002 Trial J Clin Oncol 2006.
- Nordlinger B., Sorbye H., Glimelius B., et al. Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial. Lancet 2008;371(9617): 1007-16.
Arquivos suplementares
