Diabetic distal polyneuropathy: the principles of diagnostics and therapy


Citar

Texto integral

Acesso aberto Acesso aberto
Acesso é fechado Acesso está concedido
Acesso é fechado Acesso é pago ou somente para assinantes

Resumo

The article discusses the clinical manifestations of diabetic distal polyneuropathy (DPN), the diagnosis of this complication, and the principles of therapy. Particular attention is paid to the treatment of DPN with pregabalin (Lyrica). The review of studies on the efficacy and safety of the use of pregabalin in diabetic patients with DPN is presented. Indication for the prescription of pregabalin includes the presence of characteristic symptoms of DPN. The initial dosage is 150 mg/day with a dose titration every 7 days, if necessary. In general, the drug is well tolerated, the side effects are associated with the mechanism of its action, and are transient, as a rule. The drug can be taken for a long time without reducing its effectiveness.

Texto integral

Acesso é fechado

Sobre autores

E. Komelyagina

SBHCI «Endocrinological Dispensary» of the Moscow Healthcare Department

Email: komelelena@yandex.ru

M. Antsiferov

SBHCI «Endocrinological Dispensary» of the Moscow Healthcare Department

PhD, Head of the Department of Diabetic Foot

Bibliografia

  1. Shaw J.E., Zimmet P.Z., Gries F.A., Ziegler D. Epidemiology of Diabetic Neuropathy In: Textbook of Diabetic Neuropathy, Thieme 2002. Р 64-79.
  2. Tesfaye S., Chaturvedi N, Eaton S.E., Ward J.D., Manes C., lonescu-Tirgoviste C., Witte D.R., Fuller J.H. Vascular Risk Factors and Diabetic Neuropathy. N. Engl. J. Med. 2005;27:341-50.
  3. Boulton A.J., Gries F.A. Guidelines for the diagnosis and outpatient management of diabetic peripheral neuropathy. In: Textbook of Diabetic Neuropathy, Thieme. 2002. Р 378-85.
  4. The Diabetes Control and Complication Trial Research Group. The effect of intensive diabetes therapy on the development and progression of diabetic neuropathy. Ann. Intern. Med. 1995;122:561-68.
  5. Ziegler D. Treatment of neuropathic pain. In: Textbook of Diabetic Neuropathy, Thieme. 2002. Р. 211-24.
  6. Алгоритмы специализированной медицинской помощи больным сахарным диабетом, 8-й выпуск. М., 2017.
  7. Freeman R., Urso-Dr-Cruz E., Emir B. Efficacy, safety, and tolerability of pregabilin treatment for painful diabetic peripheral neuropathy: finding from seven randomized, controlled trials across a range of doses. Diabetes Care. 2008;31(7):1448-54.
  8. Freynhagen R., Strojek K., Griesing T., et al. Efficacy of pregabalin in neuropathic painevaluated in a 12-week, randomised, double-blind, multicentre, placebo-controlled trial of flexible and fixed-dose regimens.Pain. 2005;115(3):254-63.
  9. Mallison R., Tilke C., Brasser M., Pittrow D. Efficacy and tolerability of pregabalin in patients with neuropathic pain. Observational study under clinical practice conditions. MMW Fortschr. Med. 2007;(149):13-20.
  10. Portenoy R., et al. Poster presented at the 25th Annual Scientific Meeting of the American Pain Society; 3-6 May 2006; San Antonio, Texas.

Arquivos suplementares

Arquivos suplementares
Ação
1. JATS XML

Declaração de direitos autorais © Bionika Media, 2017

Este site utiliza cookies

Ao continuar usando nosso site, você concorda com o procedimento de cookies que mantêm o site funcionando normalmente.

Informação sobre cookies