MUCOLYTICS IN THE TREATMENT OF COUGH IN CHILDREN: COMPLEXITY OF PROPERTIES
- Autores: Shatalina S.I1, Kolosova N.G1, Aksenova M.B1, Khlevchuk T.V1
-
Afiliações:
- Sechenov First Moscow State Medical University (Sechenov University)
- Edição: Nº 8 (2018)
- Páginas: 84-89
- Seção: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/295566
- DOI: https://doi.org/10.18565/pharmateca.2018.8.84-88
- ID: 295566
Citar
Texto integral
Acesso aberto
Acesso está concedido
Acesso é pago ou somente para assinantes
Resumo
Acute respiratory diseases continue to occupy the first place in the structure of childhood morbidity. This is associated with the large number and variability of strains of respiratory infections, as well as the periodic discovery of their new species. Cough in children is one of the most common complaints in the development of respiratory diseases. However, it is necessary to keep in mind extrapulmonary diseases that occur with the development of this symptom. In case of respiratory diseases in children, mucolytics are considered as the drug of choice in the treatment of cough. The advantage of mucolytics includes the ability to dilute sputum without increasing its quantity. Antioxidant and anti-inflammatory effects of mucolytics speed up the recovery of patients. The ability of these drugs to prevent the adhesion of bacteria to the epithelium of the upper respiratory tract and their influence on the destruction of biofilms reduce the incidence of infectious complications of acute respiratory viral infections in children.
Palavras-chave
Texto integral
Sobre autores
S. Shatalina
Sechenov First Moscow State Medical University (Sechenov University)
Email: svetlanashatalina@mail.ru
PhD, Teaching Assistant at the Department of Children Diseases of the Faculty of General Medicine
N. Kolosova
Sechenov First Moscow State Medical University (Sechenov University)
M. Aksenova
Sechenov First Moscow State Medical University (Sechenov University)
T. Khlevchuk
Sechenov First Moscow State Medical University (Sechenov University)
Bibliografia
- Mall M.A. Role of cilia, mucus, and airway surface liquid in mucociliary dysfunction: lessons from mouse models. J Aerosol Med Pulm Drug Deliv. 2008;21(1):13-24. Doi: 10.1089/ jamp.2007.0659.
- Teff Z., Priel Z., Ghebery L.A. Forces Applied by Cilia Measured on Explants from Mucociliary Tissue. Biophysical J. 2007;92:1813-23. Doi:10.1529/ biophysj.106.094698.
- Stannard W., O'Callaghan C. Ciliary function and the role of cilia in clearance. J Aerosol. Med. 2006;19(1):110-15. Doi: 10.1089/ jam.2006.19.110.
- Козлов В.С., Шиленкова В.В., Азатян А.С., Крамной А.И. Мукоцилиарный транспорт и двигательная активность цилиарного аппарата слизистой оболочки носа у больных хроническим полипозным риносинуситом. Вестник оториноларингологии. 2008;2:10 13
- Сухарев А.Е., Ермолаева Т.Н., Беда Н.А., Мамаева С.А. Иммунохимическое исследование бронхиального секрета в оценке степени эндобронхита. Фундаментальные исследования. 2004:2:27-34
- Чучалин А.П., Абросимов В.Н. Кашель. Изд. 2-е, перераб и доп. М.: Человек и лекарство, 2012. 127 с
- Respiratory Medicine (ERS/Handbook). Ed. P Palange, A. Simonds. Printed in the UK by Latimer Trend&Co. Ltd. 2010. 462 c
- Зайцева О.В., Барденикова С.И., Зайцева С.В. и др. Современные аспекты патогенетической терапии кашля у детей. Лечащий врач. 2010;2. http://www. lvrach.ru/2010/02/12158998/
- Комплексный подход к лечению и профилактике острых респираторных инфекций у детей: Практическое руководство для врачей / Под ред. проф. Н.А. Геппе, проф. А.Б. Малахова. М., 2012. 47 с
- Таточенко В.К. Дифференциальная диагностика кашля у детей и его лечение. Лечащий врач. 2008;3:60-65
- Колосова Н.Г., Шаталина С.И. Диагностика и лечение кашля у детей. Лечащий врач. 2015;10:23
- Ковалева И. Ацетилцистеин спешит на помощь. Да Сигна. 2018;3:13
- Zafarullah M., Li W.Q., Sylvester J., et al. Molecular mechanisms of N-acetylcysteine actions. Cell. Mol. Life Sci. 2003;60:6-20.
- Chalumeau M., Duijvestijn Y.C.M. Acetylcysteine and carbocysteine for acute upper and lower respiratory tract infections in paediatric patients without chronic broncho-pulmonary disease (Review). The Cochrane Library. 2013;Issue 5.
- Hayashi H. Inhibitory effect of nasal mucus on the absorption of drugs through respiratory epithelium. Nippon Jibiinkoka Gakkai Kaiho 1990;93:40-49.
- Bergstrand H., Bjornson A., Eklund A., et al. Stimuli-induced superoxide radical generation in vitro by human alveolar makrophages from smokers: modulation by N-acetylcysteine treatment in vivo. J. Free Radic. Biol. Med. 1986;2:119-27.
- Локшина Э.Э., Зайцева О.Л., Зайцева С.В. Новые возможности муколитической терапии у детей с острыми респираторными заболеваниями. Вопросы практической педиатрии. 2011;6(1):67-72.
- Riise G.C., Qvarfordt I., Larsson S., et al. Inhibitory effect of N-acetylcysteine on adherence of Streptococcus pneumoniae and Haemophilus influenzae to human oropharyngeal epithelial cells in vitro. Respiration. 2000;67:552-58. doi: 10.1159/000067473
- Macchi A., Ardito F., Marchese A., et al. Efficacy of N-acetylcisteine in combination with thiamphenicol in sequential (intramuscular/aerosol) therapy of upper respiratory tract infections even if sustained by bacterial biofilms. J Chemother. 2006;18:507-13. doi: 10.1179/joc.2006.18.5.507
- Геппе Н.А., Малахов А.Б., Зайцева О.В., и др. Спорные и нерешенные вопросы в терапии кашля у детей в амбулаторной практике. Педиатрия (Прил. к журн. Consilium Medicum). 2017;4
- Инструкция по применению ЭСПА-НАЦ® http:// esparma-gmbh.ru/espa-nats
Arquivos suplementares
