INFLUENCE OF SHORT-TERM TREATMENT WITH A ZOPICLONE ON BALANCE IN CHRONIC INSOMNIA: CLINICAL CASE
- Autores: Tsenteradze S.L1, Poluektov M.G1, Antonenko L.M1
-
Afiliações:
- Sechenov First Moscow State Medical University (Sechenov University)
- Edição: Nº 3S (2018)
- Páginas: 63-67
- Seção: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/296546
- DOI: https://doi.org/10.18565/pharmateca.2018.s3.63-67
- ID: 296546
Citar
Texto integral
Acesso aberto
Acesso está concedido
Acesso é pago ou somente para assinantes
Resumo
Background. The most common pharmacological treatment for insomnia is third generation hypnotics, among which zopiclone occupies one of the leading places.Despite the known negative effect of hypnotics on postural functions, sleep improvement in patients with chronic insomnia eventually leads to an improvement in the balance. We present a clinical case of effective treatment of insomnia, accompanied by an improvement in postural stability. Description of the clinical case. The results of the use of zopiclone (Somnol, 7.5 mg for 10 days 40 minutes before bedtime) in a 64-year-old patient with chronic insomnia accompanied by dizziness and walking unstability are considered. This therapy provided a significant improvement in sleep indices, accompanied by an increase in postural stability. Conclusion. There was no possible adverse effect of zopiclone on balance in the case presented. This may be due to the fact that zopiclone itself does not have such a negative effect, or the effect of normalizing sleep exceeded the negative effect of the drug. It is obvious that in many cases the meaning elderly people off hypnotics is not justified, and the doctor should independently correlate the risk and benefit from the appointment of such treatment in each case.
Palavras-chave
Texto integral
Sobre autores
S. Tsenteradze
Sechenov First Moscow State Medical University (Sechenov University)
Email: s.tsenteradze@mail.ru
M. Poluektov
Sechenov First Moscow State Medical University (Sechenov University)
L. Antonenko
Sechenov First Moscow State Medical University (Sechenov University)
Bibliografia
- LaFont C., Baroni A., Allard M., et al. Falls, Gait and Balance Disorders in the Elderly: From Successful Aging to Frailty (Facts and Research in Gerontology). New York: Springer Publishing Company, 1996. P. 185.
- Morad Yю, Azaria B., Avni I., et al. Posturography as an indicator of fatigue due to sleep deprivation. Aviat. Space Environ Med. 2007;78(9):859-63.
- Patel M., Gomez S., Berg S., et al. Effects of 24-h and 36-h sleep deprivation on human postural control and adaptation. Exp. Brain Res. 2008;185(2):165-73.
- Ma J., Yao Y., Ma R., et al. Effects of sleep deprivation on human postural control, subjective fatigue assessment and psychomotor performance. J. Int. Med. Res. 2009;37(5):1311-20.
- Robillard R., Prince F., Filipini D., Carrier J. Aging Worsens the Effects of Sleep Deprivation on Postural Control. PloSOne. 2011;6(12):e28731.
- Kolla B., lovely J., Mansukhani M., Morgenthaler T. Zolpidem is independently associated with increased risk of inpatient falls. J. Hosp. Med. 2013;8(1):1-6.
- Johns M.W. Daytime sleepiness, snoring, and obstructive sleep apnea. The Epworth sleepiness scale. Chest. 1993;103(1):30-6.
- Morin С., Belleville G., Belanger L. The ISI: Psychometric Indicators to detect Insomnia Cases and Evaluate Treatment Response. Sleep. 2011;34(5):601-8.
- Buysse D.J., Reynolds C.F., Monk T.H., et al. The Pittsburgh Sleep Quality Index (PSQI): a new instrument for psychiatric research and practice. Psychiatry Res. 1989;28:193-213.
- Srijithesh P.R., Shukla G., Srivastav A., et al. Validity of the Berlin Questionnaire in identifying obstructive sleep apnea syndrome when administered to the informants of stroke patients. J. Clin. Neurosci. 2011;18(3):340-43.
- Исследование тревожности (Ч.Д. Спилбергер, адаптация Ю.Л. Ханин). Диагностика эмоционально-нравственного развития. Ред. и сост. Дерманова И.Б. СПб., 2002. С. 124-26.
- Beck A.T., Steer R.A., Brown G. Beck Depression Inventory-II. PsycTESTS Dataset. Available at: http:/ dx.doi.org/10.1037/t00742-000.
- Захаров В.В. Нейропсихологические тесты. Необходимость и возможность применения. Consilium Medicum. 2011;13(2):82-90.
- The International classification of sleep disorders [Diagnostic and coding manual]. American Academy of Sleep Medicine. U.S.A.: Darien, 2014.
- Drover D.R. Comparative pharmacokinetics and pharmacodynamics of short-acting hypnosedatives: zaleplon, zolpidem and zopiclone. Clin. Pharmacokinet. 2004;43(4):227-38.
- Javelot H., Marquis A., Antoine-Bernard E., et al. Benzodiazepines Withdrawal: Initial Outcomes and Long-Term Impact on Falls in a French Nursing Home. Pharmacy (Basel). 2018;6(2):E30.
- Mets M.A., Volkerts E.R., Olivier B., Verster J.C. Effect of hypnotic drugs on body balance and standing steadiness. Sleep Med. Rev. 2010;14(4):259-67.
- Центерадзе С.Л., Полуэктов М.Г., Антоненко Л.М. Влияние нарушений сна на показатели равновесия у больных дисциркуляторной энцефалопатией. Эффективная фармакотерапия. Неврология. Спецвыпуск «Сон и его расстройства - 5». 2017:90-5.
Arquivos suplementares
