No 3S (2018)

Objective: to analyze the effectiveness of a short course of treatment with ursodeoxycholic acid (preparation Grinterol, Grindex) in cholestatic syndrome. Methods. 30 patients with clinical and laboratory manifestations of cholestasis were included in the study. All patients were prescribed a preparation Grinterol at the dose of 250 mg every 25 kg of body weight for two months, and a diet for patients with diseases of the bile ducts was also recommended. Results. The results indicate high efficacy (significant improvement of clinical and laboratory indicators) and safety (no side effects) of this drug, which allows recommending it for widespread use in patients with signs of cholestasis.

Background. To implement the state task of the Ministry of Health of the Russian Federation № ГР АААА-А18-118011190076-1 «Introduction of technology of patient-oriented treatment for patients with chronic internal diseases associated with metabolic syndrome», the Register of students of the Medical Faculty of the Omsk State Medical University was created to develop a scale for the assessment of potential adherence to treatment (RAKURS). Objective: is the development of design, structure and main directions of the formation and use of the register. Methods. The design of the study determined the formation of primary database on the expected adherence to treatment for students of all university classes with the ability of prospective database seeding in a format of cross-sectional study. The criteria for the formation of the register included the depersonalization (coding) of information about the participant at baseline; inclusion of data on participants in the general population who participated in paper-and-pencil interviewing during formation of continuous cross-sectional register sample, including sex, age, height, body weight, average monthly income, training course, history of chronic somatic diseases; formation of an autonomous electronic database of the register; development, creation and official registration of software products that ensure the functionality of the register in terms of storage, automated processing and use of data. Results. The processing of data included in the Respondent Register serves as a basis for quantifying the expected integral adherence to treatment and its individual components. Conclusion. Assessment of these indicators allows to form mean-sample parameters and scale of expected adherence to treatment, typical for the sample of respondents controlled by age, sex, average income and educational level.

The imbalance in the intake of calcium and magnesium is one of the modern world trends. It is based on irrational nutrition, the intake of additional sources of calcium in the form of oral nutritional supplements without taking into account the calcium/magnesium balance. The data presented in the article indicate the advisability of the combined use of calcium and magnesium compounds for the prevention of osteoporosis of various genesis and in conditions accompanied by an increased need for calcium.

A typical clinical manifestation of odontogenic atypical pain is the daily dull toothache of undefined localization in the absence of any pathology. The article discusses the problems of the clinical manifestations, diagnostics, and differential diagnosis of odontogenic atypical pain. Treatment of this type of atypical pain requires a multidisciplinary approach.

Ebastine is a selective H1-histamine receptor antagonist, without anticholinergic and sedative effects in the permitted doses. In clinical use, ebastin is characterized by a rapid onset and a long duration of antiallergic action. The drug has a high clinical efficacy and a favorable safety profile regardless of dose.

Currently, there is no doubt about close relationship between non-alcoholic fatty liver disease (NAFLD) and cholelithiasis. It has been established that the high prevalence and progression rate of NAFLD, as well as cholelithiasis, depend on a number of risk factors, which are predominantly common. For example, NAFLD is 3.5 times more likely to be associated with cholelithiasis than with other diseases of the gastrointestinal tract (GIT). In turn, cholelithiasis can have serious metabolic effects predisposing to the development of NAFLD, and bile acids are now considered less as «surfactants/detergents» facilitating fat absorption, as previously thought, than as signaling molecules that coordinate the regulation of metabolism and inflammation, and not only in the GIT, but also in other organs and systems. It still remains unclear what disease develops primarily, or they are developed in parallel, but their negative impact on each other is precisely known.

The article analyzes the features of the activity of health facilities in the state health system,depending on the organizational and legal form. The first step in the structural reform of domestic healthcare system was the change in the organizational and legal form of state and municipal healthcare organizations, divided into three types: state, budget and autonomous institutions. After the organizational and legal reorganization of healthcare institutions, budget institutions in the national healthcare system accounted for about 89% of the total number of state healthcare organizations.