Some aspects of interstitial lung disease associated with leflunomide therapy in patients with rheumatoid arthritis


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Resumo

The article analyzes publications related to interstitial lung disease (ILD) caused by taking leflunomide (LEF) during the treatment of rheumatoid arthritis. Being an effective disease modifying antirheumatic drug, LEF can provoke the development of severe forms of ILD in rheumatoid arthritis with a fatal outcome. At the same time, it is possible that the process is more acute than that of methotrexate-induced IDL. Prospective randomized controlled trials are required to further evaluation of the effect of LEF on the development and course of ILD.

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Sobre autores

D. Bestaev

North Ossetian State Medical Academy (NOSMA)

Email: avidbestaev@rambler.ru
Dr. Sci. (Med.), Head of the Department of Internal Diseases № 3 40, Pushkinskaya str., Republic of North Ossetia-Alania, Vladikavkaz 362019, Russian Federation

Z. Brtsieva

North Ossetian State Medical Academy (NOSMA)

Vladikavkaz, Russia

S. Ktsoeva

North Ossetian State Medical Academy (NOSMA)

Vladikavkaz, Russia

L. Khutieva

North Ossetian State Medical Academy (NOSMA)

Vladikavkaz, Russia

N. Burduli

North Ossetian State Medical Academy (NOSMA)

Vladikavkaz, Russia

O. Kotsoeva

North Ossetian State Medical Academy (NOSMA)

Vladikavkaz, Russia

T. Bestaeva

Family Medicine Clinic

Vladikavkaz, Russia

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