Carriage of the COMT rs4680 polymorphic variant is associated with better tolerance to antipsychotics in adolescents with an acute psychotic episode: a prospective observational clinical study
- Autores: Ivashchenko D.V.1,2, Ivanyuta M.V3, Buromskaya N.I4, Shimanov P.V4, Deitch R.V4, Nastovich M.I4, Akmalova K.A1, Kachanova A.A1, Grishina E.A1, Savchenko L.M1, Shevchenko Y.S1, Sychev D.A1
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Afiliações:
- Russian Medical Academy of Continuous Professional Education
- Penza Institute for Advanced Medical Education - Branch of the Russian Medical Academy of Continuous Professional Education
- Pirogov Russian National Research Medical University (Pirogov Medical University)
- G.E. Sukhareva Scientific and Practical Center for Mental Health of Children and Adolescents
- Edição: Volume 28, Nº 3 (2021)
- Páginas: 62-67
- Seção: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/313105
- DOI: https://doi.org/10.18565/pharmateca.2021.3.62-67
- ID: 313105
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Sobre autores
Dmitriy Ivashchenko
Russian Medical Academy of Continuous Professional Education; Penza Institute for Advanced Medical Education - Branch of the Russian Medical Academy of Continuous Professional Education
Email: dvi1991@yandex.ru
Cand. Sci. (Med.) Moscow, Russia
M. Ivanyuta
Pirogov Russian National Research Medical University (Pirogov Medical University)Moscow, Russia
N. Buromskaya
G.E. Sukhareva Scientific and Practical Center for Mental Health of Children and AdolescentsMoscow, Russia
P. Shimanov
G.E. Sukhareva Scientific and Practical Center for Mental Health of Children and AdolescentsMoscow, Russia
R. Deitch
G.E. Sukhareva Scientific and Practical Center for Mental Health of Children and AdolescentsMoscow, Russia
M. Nastovich
G.E. Sukhareva Scientific and Practical Center for Mental Health of Children and AdolescentsMoscow, Russia
K. Akmalova
Russian Medical Academy of Continuous Professional EducationMoscow, Russia
A. Kachanova
Russian Medical Academy of Continuous Professional EducationMoscow, Russia
E. Grishina
Russian Medical Academy of Continuous Professional EducationMoscow, Russia
L. Savchenko
Russian Medical Academy of Continuous Professional EducationMoscow, Russia
Yu. Shevchenko
Russian Medical Academy of Continuous Professional EducationMoscow, Russia
D. Sychev
Russian Medical Academy of Continuous Professional EducationMoscow, Russia
Bibliografia
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- Opgen-Rhein C., Neuhaus A.H., Urbanek C., et al. Executive Attention in Schizophrenic Males and the Impact of COMT Val108/158Met Genotype on Performance on the Attention Network Test. Schizophr Bull. 2008;34(6):1231-39. doi: 10.1093/schbul/sbm155.
- Bastos P., Gomes T., Ribeiro L. Catechol-O-methyltransferase (COMT): An update on its role in cancer, neurological and cardiovascular diseases. Rev Physiol Biochem Pharmacol. 2017;173:1-39. doi: 10.1007/112_2017_2.
- Magkas N., Tsioufis C., Thomopoulos C., et al. Orthostatic hypotension: From pathophysiology to clinical applications and therapeutic considerations. J Clin Hypertens. 2019;21(5):546-54. doi: 10.1111/jch.13521.
- Ghimire L.V., Kohli U., Li C., et al. Catecholamine pathway gene variation is associated with norepinephrine and epinephrine concentrations at rest and after exercise. Pharmacogenet Genomics. 2012;22(4):254-60. Doi: 10.1097/ FPC.0b013e328350a274.
- Hall K.T. Kossowsky J., Oberlander T.F., et al. Genetic variation in catechol-O-methyltransferase modifies effects of clonidine treatment in chronic fatigue syndrome. Pharmacogenom J. 2016;16(5):454-60. doi: 10.1038/tpj.2016.53.
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