Prospects for the use of fetal estrogen estetrol in endocrine gynecology
- Autores: Apetov S.S1, Apetova V.V1
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Afiliações:
- Endocrine Health Center
- Edição: Volume 29, Nº 6 (2022)
- Páginas: 22-29
- Seção: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/321009
- DOI: https://doi.org/10.18565/pharmateca.2022.6.22-29
- ID: 321009
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Resumo
Estrogens and gestagens have been used for hormonal contraception, treatment of gynecological diseases and pathological conditions in women for many decades. The use of these drugs may be associated with a number of rare but extremely adverse side effects, including an increased risk of venous and arterial thromboembolism, dyslipidemia and insulin resistance, and breast cancer; therefore, the development of new components of combined hormonal contraceptives and menopausal hormone therapy still remains a critical task. In recent years, clinical trials of new drugs containing the natural fetal estrogen estetrol have been conducted. It is believed that the new estrogenic component will reduce the adverse effects associated with taking estrogens and increase adherence to both hormonal contraception and menopausal hormone therapy for menopausal disorders. The purpose of this review is to assess the benefits and risks of using estetrol in endocrine gynecology
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Sobre autores
S. Apetov
Endocrine Health Center
Email: apetov@rambler.ru
Chelyabinsk, Russia
V. Apetova
Endocrine Health CenterChelyabinsk, Russia
Bibliografia
- Holinka C.F, Diczfalusy E., Coeling Bennink H.J.T.C. Estetrol: A unique steroid in human pregnancy. J Steroid Biochem Mol Biol. 2008;110:138-43. doi: 10.1016/j.jsbmb.2008.03.027.
- Zucconi G, Lisboa B.P., Simonitsch E., et al. Isolation of 15-alpha-hydroxy-oestriol from pregnancy urine and from the urine of newborn infants. Acta Endocrinol (Copenh). 1967;56(3):413-23. doi: 10.1530/acta.0.0560413.
- Visser M, Coelingh Bennink H.J. Clinical applications for estetrol. J Steroid Biochem Mol Biol. 2009;114(1-2):85-9. Doi: 10.1016/j. jsbmb.2008.12.013.
- Benagiano G., Mancuso S., Mancuso F.P, et al. Studies on the metabolism of C-19 steroids in the human foeto-placental unit. 3. Dehydrogenation and reduction prducts formed by previable foetuses with androstenedione and testosterone. Acta Endocrinol (Copenh). 1968;57(2):187-207. doi: 10.1530/acta.0.0570187.
- Coelingh Bennink F., Holinka C.F., Visser M., et al. Maternal and fetal estetrol levels during pregnancy. Climacteric. 2008;11(Suppl 1):69- doi: 10.1080/13697130802056321.
- Tskitishvili E, Nisolle M., Munaut C., et al. Estetrol attenuates neonatal hypoxic-ischemic brain injury. Exp Neurol. 2014;261:298-307. doi: 10.1016/j.expneurol.2014.07.015.
- Visser M, Holinka C.F., Coelingh Bennink H.J. First human exposure to exogenous single-dose oral estetrol in early postmenopausal women. Climacteric. 2008;11(Suppl 1:31-40. doi: 10.1080/13697130802056511.
- Coelingh Bennink H.J., Holinka C.F., Diczfalusy E. Estetrol review: profile and potential clinical applications. Climacteric. 2008;11(Suppl 1):47-doi: 10.1080/13697130802073425.
- Coelingh Bennink H.J.T., Verhoeven C., Zimmerman Y, et al. Pharmacokinetics of the fetal estrogen estetrol in a multiple-rising-dose study in postmenopausal women.Climacteric. 2017;20(3):285-89. doi: 10.1080/13697137.2017.1291608.
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