Prospects for the use of fetal estrogen estetrol in endocrine gynecology
- Authors: Apetov S.S1, Apetova V.V1
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Affiliations:
- Endocrine Health Center
- Issue: Vol 29, No 6 (2022)
- Pages: 22-29
- Section: Articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/321009
- DOI: https://doi.org/10.18565/pharmateca.2022.6.22-29
- ID: 321009
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Abstract
Estrogens and gestagens have been used for hormonal contraception, treatment of gynecological diseases and pathological conditions in women for many decades. The use of these drugs may be associated with a number of rare but extremely adverse side effects, including an increased risk of venous and arterial thromboembolism, dyslipidemia and insulin resistance, and breast cancer; therefore, the development of new components of combined hormonal contraceptives and menopausal hormone therapy still remains a critical task. In recent years, clinical trials of new drugs containing the natural fetal estrogen estetrol have been conducted. It is believed that the new estrogenic component will reduce the adverse effects associated with taking estrogens and increase adherence to both hormonal contraception and menopausal hormone therapy for menopausal disorders. The purpose of this review is to assess the benefits and risks of using estetrol in endocrine gynecology
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About the authors
S. S Apetov
Endocrine Health Center
Email: apetov@rambler.ru
Chelyabinsk, Russia
V. V Apetova
Endocrine Health CenterChelyabinsk, Russia
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