Lorlatinib in the treatment of ALK-positive non-small cell lung cancer

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Resumo

Due to the advent of targeted drugs in the treatment of ALK-positive non-small cell lung cancer, it has now become possible to prescribe treatment that is more effective and less toxic than chemotherapy. This review focuses on the latest approved third-generation ALK inhibitor, lorlatinib. The data of clinical studies, confirming the effectiveness of the drug both in the first and subsequent lines of therapy, as well as the place of the drug in accordance with currently accepted clinical guidelines are presented. A clinical observation demonstrating the effectiveness of the drug in a patient with ALK-positive non-small cell lung cancer in the second line of therapy is discussed.

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Sobre autores

Olga Gordeeva

Lopukhin Federal Research and Clinical Center of Physical and Chemical Medicine of Federal Medical and Biological Agency

Autor responsável pela correspondência
Email: gordeeva.o@rcpcm.org
ORCID ID: 0000-0002-8266-0218

Cand. Sci. (Med.), Oncologist, Chemotherapist

Rússia, Moscow

N. Meshcheryakova

National Medical Research Center of Oncology. N.N. Blokhin

Email: gordeeva.o@rcpcm.org
Rússia, Moscow

A. Meshcheryakov

Lopukhin Federal Research and Clinical Center of Physical and Chemical Medicine of Federal Medical and Biological Agency

Email: gordeeva.o@rcpcm.org
ORCID ID: 0000-0002-6009-653X
Rússia, Moscow

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