Efficacy of pentahydroxyethylnaphthoquinone for the treatment and prevention of retinopathy of prematurity
- Autores: Feoktistova Y.V.1, Poddubniy E.A.1, Tyrtyshnikova A.V.1, Eliseeva E.V.1, Feoktistova E.D.1, Shulgina N.A.1
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Afiliações:
- Pacific State Medical University
- Edição: Volume 30, Nº 4/5 (2023)
- Páginas: 115-120
- Seção: Original articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/568053
- DOI: https://doi.org/10.18565/pharmateca.2023.4-5.115-120
- ID: 568053
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Resumo
Background. Retinopathy of prematurity (RP) remains one of the causes of bilateral visual impairment in children. The main cause of RP is not only an imbalance of factors regulating angiogenesis, but also oxidative stress.
Objective. Meta-analysis of studies of the pentahydroxyethylnaphthoquinone, which was developed, patented and has a full production cycle in the Russian Federation; evaluation of the effectiveness of its use in premature newborns to prevent the development and progression of retinopathy.
Methods. The effectiveness of pentahydroxyethylnaphthoquinone in premature newborns to prevent the development and progression of retinopathy was evaluated.
Results. A pilot meta-analysis on the use of pentahydroxyethylnaphthoquinone indicates its benefits in preventing the development and progression of retinopathy. The results depend on the methodology and methods of the study, and therefore should be taken with caution. At the same time, the findings correlate with the positive experience of using this drug in the Russian Federation.
Conclusion. The minimum number of studies included in the meta-analysis allows for indicative results. With a large number of studies in different groups of patients, it is possible that different results will be obtained.
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Sobre autores
Yu. Feoktistova
Pacific State Medical University
Email: evgeny_brain@rambler.ru
ORCID ID: 0000-0003-4070-9842
Rússia, Vladivostok
Evgeny Poddubniy
Pacific State Medical University
Autor responsável pela correspondência
Email: evgeny_brain@rambler.ru
ORCID ID: 0000-0003-0075-303X
Código SPIN: 6109-7743
Cand. Sci. (Med.), Associate Professor, Department of General and Clinical Pharmacology
Rússia, VladivostokA. Tyrtyshnikova
Pacific State Medical University
Email: evgeny_brain@rambler.ru
ORCID ID: 0000-0002-8947-7803
Rússia, Vladivostok
E. Eliseeva
Pacific State Medical University
Email: evgeny_brain@rambler.ru
ORCID ID: 0000-0001-6126-1253
Rússia, Vladivostok
E. Feoktistova
Pacific State Medical University
Email: evgeny_brain@rambler.ru
ORCID ID: 0000-0001-8382-4184
Rússia, Vladivostok
N. Shulgina
Pacific State Medical University
Email: evgeny_brain@rambler.ru
ORCID ID: 0000-0002-3105-2562
Rússia, Vladivostok
Bibliografia
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