Efficacy of pentahydroxyethylnaphthoquinone for the treatment and prevention of retinopathy of prematurity
- 作者: Feoktistova Y.V.1, Poddubniy E.A.1, Tyrtyshnikova A.V.1, Eliseeva E.V.1, Feoktistova E.D.1, Shulgina N.A.1
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隶属关系:
- Pacific State Medical University
- 期: 卷 30, 编号 4/5 (2023)
- 页面: 115-120
- 栏目: Original articles
- URL: https://journals.eco-vector.com/2073-4034/article/view/568053
- DOI: https://doi.org/10.18565/pharmateca.2023.4-5.115-120
- ID: 568053
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详细
Background. Retinopathy of prematurity (RP) remains one of the causes of bilateral visual impairment in children. The main cause of RP is not only an imbalance of factors regulating angiogenesis, but also oxidative stress.
Objective. Meta-analysis of studies of the pentahydroxyethylnaphthoquinone, which was developed, patented and has a full production cycle in the Russian Federation; evaluation of the effectiveness of its use in premature newborns to prevent the development and progression of retinopathy.
Methods. The effectiveness of pentahydroxyethylnaphthoquinone in premature newborns to prevent the development and progression of retinopathy was evaluated.
Results. A pilot meta-analysis on the use of pentahydroxyethylnaphthoquinone indicates its benefits in preventing the development and progression of retinopathy. The results depend on the methodology and methods of the study, and therefore should be taken with caution. At the same time, the findings correlate with the positive experience of using this drug in the Russian Federation.
Conclusion. The minimum number of studies included in the meta-analysis allows for indicative results. With a large number of studies in different groups of patients, it is possible that different results will be obtained.
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作者简介
Yu. Feoktistova
Pacific State Medical University
Email: evgeny_brain@rambler.ru
ORCID iD: 0000-0003-4070-9842
俄罗斯联邦, Vladivostok
Evgeny Poddubniy
Pacific State Medical University
编辑信件的主要联系方式.
Email: evgeny_brain@rambler.ru
ORCID iD: 0000-0003-0075-303X
SPIN 代码: 6109-7743
Cand. Sci. (Med.), Associate Professor, Department of General and Clinical Pharmacology
俄罗斯联邦, VladivostokA. Tyrtyshnikova
Pacific State Medical University
Email: evgeny_brain@rambler.ru
ORCID iD: 0000-0002-8947-7803
俄罗斯联邦, Vladivostok
E. Eliseeva
Pacific State Medical University
Email: evgeny_brain@rambler.ru
ORCID iD: 0000-0001-6126-1253
俄罗斯联邦, Vladivostok
E. Feoktistova
Pacific State Medical University
Email: evgeny_brain@rambler.ru
ORCID iD: 0000-0001-8382-4184
俄罗斯联邦, Vladivostok
N. Shulgina
Pacific State Medical University
Email: evgeny_brain@rambler.ru
ORCID iD: 0000-0002-3105-2562
俄罗斯联邦, Vladivostok
参考
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- Omel’yanovsky V.V., Avksent’eva M.V., Sura M.V., et al. Guidelines for conducting a meta-analysis. Approved by order of the Federal State Budgetary Institution «TsEKKMP» of the Ministry of Health of Russia dated December 29, 2017 No181-od. M., 2017. 28 p. (In Russ.).
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