Adrenal masses in Gardner syndrome: difficulties in diagnosis and treatment (case report and brief review)
- Autores: Drachuk E.S.1, Gaidaichuk K.E.1, Ivaschenko K.V.1, Pachuashvili N.V.1, Urusova L.S.1, Godzenko M.V.1, Tarbaeva N.V.1, Pigarova E.A.1, Dzeranova L.K.1, Platonova N.M.1
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Afiliações:
- National Medical Research Center of Endocrinology
- Edição: Volume 32, Nº 2 (2025)
- Páginas: 166-172
- Seção: Clinical case
- URL: https://journals.eco-vector.com/2073-4034/article/view/680203
- DOI: https://doi.org/10.18565/pharmateca.2025.2.166-172
- ID: 680203
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Resumo
Gardner syndrome is an autosomal dominant disorder characterized by colorectal polyposis in combination with extraintestinal manifestations such as desmoid tumors, osteomas, and dental anomalies. Rare extraintestinal manifestations of Gardner syndrome include adrenal masses, which have been reported in 7% of patients.
The article presents a case of a 33-year-old woman with Gardner syndrome and a history of left-sided adrenalectomy for an adrenocortical adenoma with a diameter of more than 6 cm. She was referred to the Institute of Clinical Endocrinology of the National Medical Research Center of Endocrinology to clarify the indications for surgical treatment of multiple lesions of the right adrenal gland.
Review of histological preparations and immunohistochemical examination using modern algorithms for assessing oncocytic tumors of the adrenal gland allowed to exclude adrenocortical cancer in the patient. Taking into account the absence of negative dynamics in the size and structure of space-occupying lesions of the right adrenal gland, the absence of signs of their hormonal activity, no absolute indications for surgical treatment of space-occupying lesions of the right adrenal gland were identified.
Despite the prevalence of adrenal tumors in patients with Gardner syndrome, their clinical significance is limited. Management of such patients requires a multidisciplinary approach involving endocrinologists, pathologists and endocrine surgeons to prevent irrational treatment.
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Sobre autores
Elizaveta Drachuk
National Medical Research Center of Endocrinology
Email: sdr68@mail.ru
ORCID ID: 0009-0004-4524-3142
Resident
Rússia, MoscowKonstantin Gaidaichuk
National Medical Research Center of Endocrinology
Email: gaidaikon@yandex.ru
ORCID ID: 0009-0006-6107-4494
Código SPIN: 3384-1038
Resident
Rússia, MoscowKsenia Ivaschenko
National Medical Research Center of Endocrinology
Autor responsável pela correspondência
Email: kseniya223@mail.ru
ORCID ID: 0000-0002-0786-7809
Código SPIN: 4526-4222
Postgraduate Student
Rússia, MoscowNano Pachuashvili
National Medical Research Center of Endocrinology
Email: npachuashvili@bk.ru
ORCID ID: 0000-0002-8136-0117
Código SPIN: 3477-8994
Cand. Sci. (Med.)
Rússia, MoscowLiliya Urusova
National Medical Research Center of Endocrinology
Email: Urusova.Liliya@endocrincentr.ru
ORCID ID: 0000-0001-6891-0009
Código SPIN: 5151-3675
Dr. Sci. (Med.)
Rússia, MoscowMaria Godzenko
National Medical Research Center of Endocrinology
Email: godzenko.mariya@endocrincentr.ru
ORCID ID: 0000-0001-8783-008X
Código SPIN: 6012-4491
Rússia, Moscow
Natalia Tarbaeva
National Medical Research Center of Endocrinology
Email: ntarbaeva@inbox.ru
ORCID ID: 0000-0001-7965-9454
Código SPIN: 5808-8065
Cand. Sci. (Med.)
Rússia, MoscowEkaterina Pigarova
National Medical Research Center of Endocrinology
Email: kpigarova@gmail.com
ORCID ID: 0000-0001-6539-466X
Código SPIN: 6912-6331
Dr. Sci. (Med.)
Rússia, MoscowLarisa Dzeranova
National Medical Research Center of Endocrinology
Email: dzeranovalk@yandex.ru
ORCID ID: 0000-0002-0327-4619
Código SPIN: 2958-5555
Dr. Sci. (Med.)
Rússia, MoscowNadezhda Platonova
National Medical Research Center of Endocrinology
Email: doc-platonova@inbox.ru
ORCID ID: 0000-0001-6388-1544
Código SPIN: 4053-3033
Dr. Sci. (Med.)
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