Clinical experience with methylprednisolone aceponate for atopic dermatitis in young children

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Дәйексөз келтіру

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Аннотация

Atopic dermatitis, or atopic eczema, is a chronic, relapsing inflammatory skin disease characterized by generalized xerosis, erythematous rash, and intense pruritus. Clinical manifestations vary and depend on the patient’s age. As one of the most common skin diseases worldwide, atopic dermatitis represents a significant clinical and economic burden for patients and their families. Infants present particular challenges in treatment due to the anatomical and physiological characteristics of their skin and the limited range of approved topical anti-inflammatory agents. This article highlights the key aspects of topical corticosteroid use in pediatric dermatology. A clinical example of the effective use of methylprednisolone aceponate in the treatment of infantile atopic dermatitis is presented. Timely and appropriate administration of topical corticosteroids allows for rapid interruption of exacerbations of the skin condition without the development of adverse side effects.

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Авторлар туралы

Aleksandra Botkina

Pirogov Russian National Research Medical University

Email: botkina@gmail.com
ORCID iD: 0000-0001-6890-2041

Cand. Sci. (Med.), Associate Professor, Department of Hospital Pediatrics named after Academician V.A. Tabolin, Faculty of Pediatrics

Ресей, Moscow

Elvira Gumennaia

Russian Children’s Clinical Hospital – Branch of Pirogov Russian National Research Medical University

Хат алмасуға жауапты Автор.
Email: botkina@gmail.com
ORCID iD: 0000-0002-8097-2816

Dermatovenerologist, Head of the Dermatovenereology Department

Ресей, Moscow

Әдебиет тізімі

  1. Европейское руководство по лечению дерматологический заболеваний. Под редакцией Кацамбаса А.Д., Лотти Т.М. 2009. М.: «МЕДпресс-информ», 724 с. [European guidelines for the treatment of dermatological diseases. Edited by Katsambas A.D., Lotti T.M. 2009. Moscow: MEDpress-inform, 724 p. (In Russ.)]
  2. Williams H.C. Clinical practice. Atopic dermatitis. N Engl J Med. 2005;352(22):2314–2324. https://dx.doi.org/10.1056/NEJMcp042803
  3. Eichenfield L.F., Tom W.L., Chamlin S.L., et al. Guidelines of care for the management of atopic dermatitis: section 1. Diagnosis and assessment of atopic dermatitis. J Am Acad Dermatol. 2014;70(2):338–351. https://dx.doi.org/10.1016/j.jaad.2013.10.010
  4. Udkoff J., Borok J., Vaida F., et al. Assessment of the American Academy of Dermatology diagnostic criteria for pediatric atopic dermatitis and modification into a checkbox form: a cross-sectional study. Pediatr Dermatol. 2023;40(5):809–815. https://dx.doi.org/10.1111/pde.15338
  5. Jeskey J., Kurien C., Blunk H., et al. Atopic dermatitis: a review of diagnosis and treatment. J Pediatr Pharmacol Ther. 2024;29(6):587–603. https://dx.doi.org/10.5863/1551-6776-29.6.587
  6. Chu D.K., Schneider L., Asiniwasis R.N., et al. Atopic dermatitis (eczema) guidelines: 2023 American Academy of Allergy, Asthma and Immunology/American College of Allergy, Asthma and Immunology Joint Task Force on practice parameters GRADE- and institute of medicine-based recommendations. Ann Allergy Asthma Immunol. 2024;132(3):274–312. doi: 10.1016/ j.anai.2023.11.009
  7. Boguniewicz M., Fonacier L., Guttman-Yassky E., et al. Atopic dermatitis yardstick: practical recommendations for an evolving therapeutic landscape. Ann Allergy Asthma Immunol. 2018;120(1):10–22. https://dx.doi.org/10.1016/j.anai.2017.10.039
  8. Tang T.S., Bieber T., Williams H.C. Are the concepts of induction of remission and treatment of subclinical inflammation in atopic dermatitis clinically useful. J Allergy Clin Immunol. 2014;133(6):1615–1625. https://dx.doi.org/10.1016/j.jaci.2013.12.1079
  9. Sidbury R., Alikhan A., Bercovitch L., et al. Guidelines of care for the management of atopic dermatitis in adults with topical therapies. J Am Acad Dermatol. 2023;89(1):e1–e20. https://dx.doi.org/doi: 10.1016/j.jaad.2022.12.029
  10. Chu D.K., Chu A.W.L., Rayner D.G., et al. Topical treatments for atopic dermatitis (eczema): systematic review and network meta-analysis of randomized trials. J Allergy Clin Immunol. 2023;152(6):1493–1519. https://dx.doi.org/10.1016/j.jaci.2023.08.030
  11. Niedner R. Therapie mit systemischen glukokortikoiden [Therapy with systemic glucocorticoids]. Hautarzt. 2001;52(11):1062–1071. https://dx.doi.org/10.1007/pl00002604
  12. Galli E., Neri I., Ricci G., et al. Consensus conference on clinical management of pediatric atopic dermatitis. Ital J Pediatr. 2016;42:26. https://dx.doi.org/10.1186/s13052-016-0229-8
  13. Wollenberg A., Kinberger M., Arents B., et al. European guideline (EuroGuiDerm) on atopic eczema – part II: non-systemic treatments and treatment recommendations for special AE patient populations. J Eur Acad Dermatol Venereol, 2022;36:1904–1926. https://doi.org/10.1111/jdv.18429
  14. Stacey S.K., McEleney M. Topical corticosteroids: choice and application. Am Fam Physician. 2021;103(6):337–343.
  15. Lax S.J., Harvey J., Axon E., et al. Strategies for using topical corticosteroids in children and adults with eczema. Cochrane Database Syst Rev. 2022;3(3):CD013356. doi: 10.1002/14651858.CD013356.pub2
  16. Torrelo A. Methylprednisolone aceponate for atopic dermatitis. Int J Dermatol. 2017;56(6):691–697. https://dx.doi.org/10.1111/ijd.13485
  17. Волкова Е.Н., Ланге Д.А., Родина Ю.А., Тарасова М.В. Метилпреднизолона ацепонат в комплексной терапии хронических дерматозов: анализ тактических ошибок применения. Клиническая дерматология и венерология. 2010;8(5):97–102. [Volkova E.N., Lange D.A., Rodina Yu.A., Tarasova M.V. Methylprednisolone aceponate in the complex therapy of chronic dermatoses: analysis of tactical errors of use. Clinical dermatology and venereology. 2010;8(5):97–102. (In Russ.)]
  18. Contento M., Cline A., Russo M. Steroid phobia: a review of prevalence, risk factors, and interventions. Am J Clin Dermatol. 2021;22(6):837–851. https://dx.doi.org/10.1007/s40257-021-00623-6

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2. Figure 1. UK Working Group criteria for diagnosis of atopic dermatitis [2]

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3. Figure 2. Principles of atopic dermatitis therapy [5]

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4. Figure 3. Features of the skin in atopic dermatitis

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5. Figure 4. Anti-inflammatory agents for external therapy of atopic dermatitis

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6. Figure 5. European classification of topical corticosteroids [11-1З]

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7. Figure 6. Rule for calculating the amount of topical agents - the "fingertip" rule

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8. Figure 7. Rules for the use of topical corticosteroids in children

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9. Figure 8. Dosage forms of methylprednisolone aceponate

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10. Figure 9. Results of allergological examination (own data)

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11. Figure 10. Skin process before and during therapy with methylprednisolone aceponate (own data)

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12. Figure 11. Severity of the disease before and during therapy with methy|prednisolone aceponate (own data)

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