АУГМЕНТИН ЕС - ПРЕПАРАТ С УСИЛЕННОЙ ФАРМАКОКИНЕТИКОЙ
- Авторы: Tatochenko VK1, Таточенко В.К.2
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Учреждения:
- НЦЗД РАМН, Москва
- Выпуск: № 14 (2010)
- Страницы: 69-72
- Раздел: Статьи
- URL: https://journals.eco-vector.com/2073-4034/article/view/278591
- ID: 278591
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Аннотация
Рассматривается ингибитор-защищенный антибиотик амоксициллин/клавуланат (Аугментин) с высокой эффективностью в отношении инфекций респираторного тракта, мягких тканей и мочевой системы. В настоящее время большинство препаратов амоксициллина/клавуланата выпускалось с соотношением компонентов 4 : 1, однако экспериментальные и клинические исследования продемонстрировали преимущества усиленных препаратов с более высоким соотношением компонентов, в частности 16 : 1 (Аугментин XR) и 14 : 1 - педиатрический сироп Аугментин ЕС. Показано, что Аугментин ЕС эффективен при остром среднем отите, в т. ч. вызванном как пневмококками со сниженной чувствительностью, так и H. influenzae и M. catarrhalis, выделяющих β-лактамазу. Препарат показан и при острых бактериальных синуситах, вызванных той же флорой, а также при других инфекциях, вызванных, например, стафилококками, часто имеющими более высокие по отношению к амоксициллину МПК.
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