Обеспеченность витамином D и метаболические нарушения: систематический анализ фундаментальных и доказательных исследований по проблемам избыточной массы тела и сахарного диабета


Цитировать

Полный текст

Открытый доступ Открытый доступ
Доступ закрыт Доступ предоставлен
Доступ закрыт Доступ платный или только для подписчиков

Аннотация

Витамин D регулирует метаболизм глюкозы и жиров. Дефицит витамина D ассоциирован с избыточным накоплением жировой ткани, глюкозотолерантностью и инсулинорезистентностью. В настоящей работе приведены результаты фундаментальных и клинических исследований, подтверждающих связь между дефицитом витамина D и формированием глюкозотолерантности, инсулинорезистентности, метаболического синдрома и сахарного диабета. Результаты клинических исследований показывают, что для терапии ожирения и диабета могут быть эффективными дозы витамина D 2000, 4000 МЕ/сут.

Полный текст

Доступ закрыт

Об авторах

О. А Громова

ГБОУ ВПО «Ивановская государственная медицинская академия» МЗ РФ; Российский сотрудничающий центр Института микроэлементов ЮНЕСКО

Email: unesco.gromova@gmail.com
д.м.н., проф. кафедры фармакологии и клинической фармакологии

И. Ю Торшин

Российский сотрудничающий центр Института микроэлементов ЮНЕСКО; ФГБУН «Вычислительный центр им. А.А. Дородницына» РАН

к.х.н., зав. лабораторией вычислительной и системной биологии

О. А Лиманова

ГБОУ ВПО «Ивановская государственная медицинская академия» МЗ РФ; Российский сотрудничающий центр Института микроэлементов ЮНЕСКО

к.м.н., доцент кафедры фармакологии и клинической фармакологии

Т. Р Гришина

ГБОУ ВПО «Ивановская государственная медицинская академия» МЗ РФ

д.м.н., проф.

А. Н Громов

ФГБУН «Вычислительный центр им. А.А. Дородницына» РАН

математик-аналитик

Список литературы

  1. Snijder M. Adiposity in relation to vitamin D status and parathyroid hormone levels: a population-based study in older men and women. J. Clin. Endocrinol. Metab. 2005; 90: 4119-23.
  2. Bodnar L.M., Catov J.M. Prepregnancy obesity predicts poor vitamin D status in mothers and their neonates. J. Nutr. 2007; 137: 2437-42.
  3. Ford E.S., Ajani U.A., et al. Concentrations of serum vitamin D and the metabolic syndrome among U.S. adults. Diabetes Care. 2005; 28: 1228-30.
  4. Norman A., Frankel J. Vitamin D deficiency inhibits pancreatic insulin secretion. Science. 1980; 109: 823-25.
  5. Forouhi N.G., Luan J., et al. Baseline serum 25-hydroxy vitamin d is predictive of future glycemic status and insulin resistance: the Medical Research Council Ely Prospective Study 19902000. Diabetes. 2008; 57: 2619-25.
  6. Mathieu C., Waer M., Laureys J. Prevention of autoimmune diabetes in NOD mice by 1,25 dihydroxyvitamin D3. Diabetologia. 1994; 37(6): 552-58.
  7. Clifton-Bligh R.J., McElduff P. Maternal vitamin D deficiency, ethnicity and gestational diabetes. Diabet Med. 2008; 25(6): 678-84.
  8. Farrant H.J., Krishnaveni G.V., et al. Vitamin D insufficiency is common in Indian mothers but is not associated with gestational diabetes or variation in newborn size. Eur. J. Clin. Nutr. 2008.
  9. Zhang C., Qiu C., Hu F.B., et al. Maternal plasma 25-hydroxyvitamin D concentrations and the risk for gestational diabetes mellitus. PLoS One. 2008; 3(11): e3753.
  10. Wallis D.E., Penckofer S., et al. The «sunshine deficit» and cardiovascular disease. Circul. 2008; 118: 1476-85.
  11. Gonzalez-Gross M., Valtuena J. Vitamin D status among adolescents in Europe: the Healthy Lifestyle in Europe by Nutrition in Adolescence study. Br. J. Nutr. 2011; 107(5): 755-64.
  12. Boucher B.J. Vitamin D insufficiency and diabetes risks. Curr. Drug Targets. 2011; 12(1): 61.
  13. Palomer X., Gonzalez-Clemente J.M. Role of vitamin D in the pathogenesis of type 2 diabetes mellitus. Diabetes Obes. Metab. 2008; 10(3): 185-97.
  14. Danescu L.G., Levy S., Levy J. Vitamin D and diabetes mellitus. Endocrine. 2009; 35(1): 11-7.
  15. Warzocha K., Ribeiro P., Bienvenu J., Roy P. Genetic polymorphisms in the tumor necrosis factor locus influence non-Hodgkin's lymphoma outcome. Blood. 1998; 91(10): 3574-81.
  16. Ganji V., Zhang X., Shaikh N. Serum 25-hydroxyvitamin D concentrations are associated with prevalence of metabolic syndrome and various cardiometabolic risk factors in US children and adolescents based on assay-adjusted serum 25-hydroxyvitamin D data from NHANES 2001-2006. Am. J. Clin. Nutr. 2011; 94(1): 225-33.
  17. Chacko S.A., Song Y. Serum 25-hydroxyvitamin D concentrations in relation to cardiometabolic risk factors and metabolic syndrome in postmenopausal women. Am. J. Clin. Nutr. 2011; 94(1): 209-17.
  18. Dalgard C., Petersen M.S. Vitamin D status in relation to glucose metabolism and type 2 diabetes in septuagenarians. Diabetes Care. 2011; 34(6): 1284-88.
  19. Kositsawat J., Freeman V.L. Association of A1C levels with vitamin D status in U.S. adults: data from the National Health and Nutrition Examination Survey. Diabetes Care. 2010; 33(6): 1236-38.
  20. Yiu Y.F., Chan Y.H. Vitamin D deficiency is associated with depletion of circulating endothelial progenitor cells and endothelial dysfunction in patients with type 2 diabetes. J. Clin. Endocrinol. Metab. 2011; 96(5): E830-35.
  21. Walker G.E., Ricotti R. Pediatric obesity and vitamin D deficiency: a proteomic approach identifies multimeric adiponectin as a key link between these conditions. PLoS One. 2014; 9(1): e83685.
  22. Haussler M.R., Jurutka P.W. Vitamin D receptor (VDR)-mediated actions of 1alpha,25(OH) (2)vitamin D(3): Genomic and non-genomic mechanisms. Best Pract. Res. Clin. Endocrinol. Metab. 2011; 25(4): 543-59.
  23. Christakos S., Dhawan P., Benn B., et al. Vitamin D: molecular mechanism of action. Ann. N.Y. Acad. Sci. 2007; 1116: 340-48.
  24. Brevetti G. IGF system and peripheral arterial disease: relationship with disease severity and inflammatory status of the affected limb. Clin. Endocrinol. (Oxf). 2008; 69(6): 894-900.
  25. Vrins C.L.1, van der Velde A.E., van den Oever K., et al. Peroxisome proliferator-activated receptor delta activation leads to increased transintestinal cholesterol efflux. J. Lipid. Res. 2009; 50(10): 2046-54.
  26. Chen S., Tsybouleva N. Effects of PPARalpha, gamma and delta haplotypes on plasma levels of lipids, severity and progression of coronary atherosclerosis and response to statin therapy in the lipoprotein coronary atherosclerosis study. Pharmacogenetics. 2004; 14(1): 61-71.
  27. Cantorna M.T., Mahon B.D. Mounting evidence for vitamin D as an environmental factor affecting autoimmune disease prevalence. Exp. Biol. Med. (Maywood). 2004; 229(11): 1136-42.
  28. Gysemans C.A., Cardozo A.K. 1.25-Dihydroxyvitamin D3 modulates expression of chemokines and cytokines in pancreatic islets: implications for prevention of diabetes in nonobese diabetic mice. Endocrinology. 2005; 146(4): 1956-64.
  29. Giulietti A., van Etten E., Overbergh L. Monocytes from type 2 diabetic patients have a pro-inflammatory profile. 1.25-Dihydroxyvitamin D(3) works as antiinflammatory. Diabetes Res. Clin. Pract. 2007; 77( 1): 47-57.
  30. Zhang Z., Yuan W., Sun L. 1,25-Dihydroxyvitamin D3 targeting of NF-kappaB suppresses high glucose-induced MCP-1 expression in mesangial cells. Kidney Int. 2007; 72(2): 193-201.
  31. Soderstrom L.H., Johnson S.P., Diaz V.A., Mainous Iii A.G. Association between vitamin D and diabetic neuropathy in a nationally representative sample: results from 2001-2004 NHANES. Diabet Med. 2011; Diabet Med: 101111/J1464-10111.
  32. Pittas A.G., Sun Q., Manson J.E. Plasma 25-hydroxyvitamin D concentration and risk of incident type 2 diabetes in women. Diabetes Care. 2010; 33(9): 2021-23.
  33. Meigs J.B., Pittas A.G., Economos C.D. Predicted 25-hydroxyvitamin D score and incident type 2 diabetes in the Framingham Offspring Study. Am. J. Clin. Nutr. 2010; 91(6): 1627-33.
  34. Brock K.E., Huang W.Y. Diabetes prevalence is associated with serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D in US middle-aged Caucasian men and women: a cross-sectional analysis within the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. Br. J. Nutr. 2011; 106(3): 339-44.
  35. Choi H.S., Kim K.A., Lim C.Y., Rhee S.Y. Low serum vitamin D is associated with high risk of diabetes in Korean adults. J. Nutr. 2011; 141: 1524-28.
  36. Gagnon C., Lu Z.X., Magliano D.J. Serum 25-hydroxyvitamin D, calcium intake, and risk of type 2 diabetes after 5 years: results from a national, population-based prospective study (the Australian Diabetes, Obesity and Lifestyle study). Diabetes Care. 2011; 34(5): 1133-38.
  37. Parker J., Hashmi O., Dutton D., Mavrodaris A. Levels of vitamin D and cardiometabolic disorders: systematic review and meta-analysis. Maturitas. 2010; 65(3): 225-36.
  38. Forouhi N.G., Ye Z. Circulating 25-hydroxyvitamin D concentration and the risk of type 2 diabetes: results from the European Prospective Investigation into Cancer (EPIC)-Norfolk cohort and updated meta-analysis of prospective studies. Diabetologia. 2012; 55(8): 2173-82.
  39. Song Y., Wang L., Pittas A.G. Blood 25-hydroxy vitamin D levels and incident type 2 diabetes: a meta-analysis of prospective studies. Diabetes Care. 2013; 36(5): 1422-28.
  40. Ju S.Y., Jeong H.S., Kim do H. Blood vitamin D status and metabolic syndrome in the general adult population: a dose-response meta-analysis. J. Clin. Endocrinol. Metab. 2014; 99(3): 1053-63.
  41. Khan H., Kunutsor S. Vitamin D, type 2 diabetes and other metabolic outcomes: a systematic review and meta-analysis of prospective studies. Proc. Nutr. Soc. 2013; 72(1): 89-97.
  42. Poel Y.H., Hummel P., Lips P., et al. Vitamin D and gestational diabetes: a systematic review and meta-analysis. Eur. J. Intern. Med. 2012; 23(5): 465-69.
  43. Spedding S. Vitamin D and depression: a systematic review and meta-analysis comparing studies with and without biological flaws. Nutrients. 2014; 6(4): 1501-18.
  44. Robinson J.G., Manson J.E., Larson J. Lack of association between 25(OH)D levels and incident type 2 diabetes in older women. Diabetes Care. 2011; 34(3): 628-34.
  45. Torshin I.Yu. Bioinformatics in the post-genomic era: physiology and medicine. Nova Biomedical Books NY USA, 2007.
  46. Joergensen C., Gall M.A., Schmedes A. Vitamin D levels and mortality in type 2 diabetes. Diabetes Care. 2010; 33(10): 2238-43.
  47. Drechsler C., Pilz S., Obermayer-Pietsch B., Verduijn M. Vitamin D deficiency is associated with sudden cardiac death, combined cardiovascular events, and mortality in haemodialysis patients. Eur. Heart J. 2010; 31(18): 2253-61.
  48. de Boer I.H., Ioannou G.N. 25-Hydroxyvitamin D levels and albuminuria in the Third National Health and Nutrition Examination Survey (NHANES III). Am. J. Kidney Dis. 2007; 50(1): 69-77.
  49. de Boer I.H., Katz R., Chonchol M., Kestenbaum B. Serum 25-hydroxyvitamin d and change in estimated glomerular filtration rate. Clin. J. Am. Soc. Nephrol. 2011; 6(9): 2141-49.
  50. Issa C., Zantout M.S., Azar S.T. Osteoporosis in men with diabetes mellitus. J. Osteoporos. 2011; 2011: 651867.
  51. Montagnani A., Gonnelli S., Alessandri M., Nuti R. Osteoporosis and risk of fracture in patients with diabetes: an update. Aging Clin. Exp. Res. 2011; (2): 84-90.
  52. Rakel A., Sheehy O., Rahme E., LeLorier J. Osteoporosis among patients with type 1 and type 2 diabetes. Diabetes Metab. 2008; 34(3): 193-205.
  53. Janghorbani M., Feskanich D., Willett W.C., Hu F. Prospective study of diabetes and risk of hip fracture: the Nurses' Health Study. Diabetes Care. 2006; 29(7): 1573-78.
  54. Mitri J., Muraru M.D., Pittas A.G. Vitamin D and type 2 diabetes: a systematic review. Eur J Clin Nutr. 2011; 65(9): 1005-15.
  55. Pittas A.G., Dawson-Hughes B., Li T. Vitamin D and calcium intake in relation to type 2 diabetes in women. Diabetes Care. 2006; 29(3): 650-56.
  56. Mitri J. Effects of vitamin D and calcium supplementation on pancreatic beta cell function, insulin sensitivity, and glycemia in adults at high risk of diabetes: the Calcium and Vitamin D for Diabetes Mellitus (CaDDM) randomized controlled trial. Am. J. Clin. Nutr. 2011; 94(2): 486-94.
  57. Aljabri K.S., Bokhari S.A., Khan M.J. Glycemic changes after vitamin D supplementation in patients with type 1 diabetes mellitus and vitamin D deficiency. Ann Saudi Med. 2010; 30(6): 454-58.
  58. fde Zeeuw D., Agarwal R., Amdahl M., Audhya P. Selective vitamin D receptor activation with paricalcitol for reduction of albuminuria in patients with type 2 diabetes (VITAL study): a randomised controlled trial. Lancet. 2010; 376(9752): 1543-51.
  59. Pittas A.G., Harris S.S., Stark P.C., Dawson-Hughes B. The effects of calcium and vitamin D supplementation on blood glucose and markers of inflammation in nondiabetic adults. Diabetes Care. 2007; 30(4): 980-86.
  60. Schnatz P.F., Jiang X., Vila-Wright S., Aragaki A.K. Calcium/vitamin D supplementation, serum 25-hydroxyvitamin D concentrations, and cholesterol profiles in the Women's Health Initiative calcium/vitamin D randomized trial. Menopause. 2014 Aug; 21(8): 823-33.
  61. Zipitis C.S., Akobeng A.K. Vitamin D supplementation in early childhood and risk of type 1 diabetes: a systematic review and meta-analysis. Arch Dis. Child. 2008; 93(6): 512-17.
  62. Hypponen E., Laara E., Reunanen A. Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet. 2001; 358(9292): 1500-503.
  63. Zipitis C.S., Akobeng A.K. Vitamin D supplementation in early childhood and risk of type 1 diabetes: a systematic review and meta-analysis. Arch. Dis. Child. 2008; 93(6): 512-17.
  64. Dong J.Y., Zhang W.G., Chen J.J., et al. Vitamin D intake and risk of type 1 diabetes: a meta-analysis of observational studies. Nutrients. 2013; 5(9): 3551-62.
  65. Nader N.S., Aguirre Castaneda R., Wallace J. Effect of Vitamin D3 Supplementation on Serum 25(OH)D, Lipids and Markers of Insulin Resistance in Obese Adolescents: A Prospective, Randomized, Placebo-Controlled Pilot Trial. Horm. Res. Paediatr. 2014; Jul 16: 107-12.
  66. Walker J.P., Hiramoto J.S. Vitamin D deficiency is associated with mortality and adverse vascular access outcomes in patients with endstage renal disease. J. Vasc. Surg. 2014; 60(1): 176-83.
  67. Radhakishun N.N., van Vliet M. Efficacy and Tolerability of a High Loading Dose (25,000 IU Weekly) Vitamin D3 Supplementation in Obese Children with Vitamin D Insufficiency / Deficiency. Horm. Res. Paediatr. 2014; Jul 19: 103-06.
  68. Yesiltepe M.G., Ozsu E., Kalaca S. Evaluation of Vitamin D Supplementation Doses during Pregnancy in a Population at High Risk for Deficiency. Horm Res Paediatr. 2014; 81(6): 402-8.
  69. Davidson M.B.1., Duran P., Lee M.L., Friedman T.C. High-dose vitamin D supplementation in people with prediabetes and hypovitaminosis D. Diabetes Care. 2013; 36(2): 260-66.
  70. Witham M.D., Dove F.J., Dryburgh M. The effect of different doses of vitamin D(3) on markers of vascular health in patients with type 2 diabetes: a randomised controlled trial. Diabetologia. 2010; 53(10): 2112-19.
  71. Громова О.А., Торшин И.Ю. Витамины и минералы: между Сциллой и Харибдой. М., 2012. 674 c.
  72. Maxwell C.S., Wood R.J. Update on vitamin D and type 2 diabetes. Nutr Rev. 2011; 69(5): 291.
  73. Mallet E. We thought everything had been said about vitamin D, but deficiency still exists and it is not only bone effects. Arch. Pediatr. 2010; 17(6): 810-11.

Дополнительные файлы

Доп. файлы
Действие
1. JATS XML
Скачать

© ООО «Бионика Медиа», 2014

Данный сайт использует cookie-файлы

Продолжая использовать наш сайт, вы даете согласие на обработку файлов cookie, которые обеспечивают правильную работу сайта.

О куки-файлах