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No 20 (2014)

Articles

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Narushenie retinal'noy tsirkulyatsii pri arterial'noy gipertenzii

Kiseleva T.N., Ezhov M.V., Adzhemyan N.A.

Abstract

Literature review is devoted to the diagnosis and screening of hypertensive retinopathy (HR). The results of large-scale epidemiological studies indicating the relationship of HR with the risk of coronary artery disease and stroke, and assessing the risk of occurrence of these states, as well as determining the effect of high blood pressure on the retinal circulation, are presented. Information about the pathophysiology of the clinical stages of retinal lesions in arterial hypertension and about the use of instrumental methods for the early diagnosis of the disease are provided.
Pharmateca. 2014;(20):14-18
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Khronicheskie zabolevaniya ven nizhnikh konechnostey: sovremennyy vzglyad na patogenez, lechenie i profilaktiku

Bogachev V.Y., Golovanova O.V., Kuznetsov A.N., Ershov P.V.

Abstract

The article presents the new epidemiological, pathogenetic and clinical data regarding chronic diseases of the venous system of the lower extremities. In particular, article discusses the modern pathogenesis of varicose veins and chronic venous insufficiency, as well as their relationship to leukocyte-endothelial reaction. The potentials for the pharmacotherapy of this pathology is analyzed.
Pharmateca. 2014;(20):19-26
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Obespechennost' vitaminom D i metabolicheskie narusheniya: sistematicheskiy analiz fundamental'nykh i dokazatel'nykh issledovaniy po problemam izbytochnoy massy tela i sakharnogo diabeta

Gromova O.A., Torshin I.Y., Limanova O.A., Grishina T.R., Gromov A.N.

Abstract

Vitamin D regulates glucose and fat metabolism. Vitamin D deficiency is associated with excessive accumulation of adipose tissue, glucose tolerance and insulin resistance. This article presents the results of fundamental and clinical studies confirming the relationship between vitamin D deficiency and the formation of glucose tolerance, insulin resistance, metabolic syndrome, and diabetes mellitus. Clinical studies show that vitamin D at doses of 2000, 4000 IU/day can be effective in the treatment of obesity and diabetes mellitus.
Pharmateca. 2014;(20):27-38
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Bol' i starenie - osobennosti lecheniya pozhilykh patsientov

Barinov A.N., Akhmedzhanova L.T., Makhinov K.A.

Abstract

Changes in the somatosensory system in aging and peripheral neuropathy are similar. Increased pain threshold against the background of axonopathy is accompanied by paradoxical decreased tolerance of pain, that associated with neuroplastic changes of spinal cord and brain. Symptomatic treatment of neuropathic pain with antidepressants, anticonvulsants and opioids is associated with a reduction in the quality of life of elderly patients and high risk of severe side effects. Pathogenetic treatment of polyneuropathy often amplifies the intensity of neuropathic pain at the beginning of therapy, however, is able to restore the function of the axon, to reduce the severity of the deficit disorders. The article discusses the ways to improve the safety of the treatment of neuropathic pain in elderly patients, the relationship of the pathogenesis of the aging of the nervous system and polyneuropathy, and the ways for their correction.
Pharmateca. 2014;(20):39-49
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Opyt primeneniya Aktovegina v lechenii neyroishemicheskoy formy sindroma «diabeticheskaya stopa»

Dibirov M.D., Gadzhimuradov R.U., Khalidov O.K., Proshin A.V., Kakubava M.R.

Abstract

The article presents the results of evaluation of the effectiveness of Actovegin in patients with ischemic form of diabetic foot syndrome (DFS), and the confirmation of the results of treatment by objective methods. It is shown that Actovegin significantly improves microcirculation in patients with ischemic form of DFS, as evidenced by an increase in microcirculation according to the data of laser Doppler flowmetry in Main group of patients.
Pharmateca. 2014;(20):50-54
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Sravnitel'naya otsenka immunomodeliruyushchikh svoystv preparatov Korteksin i Nootropil

Tsygan V.N.

Abstract

The article presents the results of a comparative evaluation of the course intraperitoneal administration of Cortexin and piracetam (Nootropil) on humoral, cellular components of the immune system and the mechanisms of innate immunity in mice. It is shown that piracetam has no immunomodulatory effect, and Cortexin administrated for 10 days stimulates T-cell response in delayed-type hypersensitivity reaction and activates the phagocytic activity of polymorphonuclear leukocytes.
Pharmateca. 2014;(20):55-58
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Effektivnost' kompleksnoy terapii s vklyucheniem preparata Adepress (paroksetin) u bol'nykh sindromom razdrazhennogo kishechnika

Belousova E.A., Podlesskikh M.N., Tsodikova O.M.

Abstract

An open comparative controlled study was performed for the assessment of the efficacy and safety of Adepress (paroxetine) with course intake of this drug in the treatment of patients with irritable bowel syndrome (IBS). The group 1 consisted of patients diagnosed with IBS who received standard treatment in combination with Adepress, the group 2 included patients with IBS syndrome who received only standard treatment without the inclusion of psychotherapeutic drugs. Adepress was administered at a dose of 20 and 10 mg daily for 6 weeks. Criteria used for the evaluation were the dynamics of the clinical symptoms (pain); normalization of indicators according to the anxiety, depression and fatigue scales. The results of study allow to recommend Adepress as an effective and safe agent in the complex therapy of IBS patients with different clinical types.
Pharmateca. 2014;(20):59-65
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Vliyanie faktorov riska serdechno-sosudistykh zabolevaniy na formirovanie arterial'noy gipertenzii u lits prizyvnogo vozrasta, po dannym kardiologicheskogo otdeleniya GBUZ RM MRKB

Usanova A.A., Guranova N.N., Fazlova I.K., Kunyaeva T.A.

Abstract

The article presents the results of evaluation of the role of risk factors (RF) for development of arterial hypertension (AH) in draft age persons, aimed to the improvement of preventive care for this population group. The total number of draft age men was 99 people aged 16 to 25 years. All draft age persons underwent examination, as recommended by the Russian Medical Society of hypertension and the All-Russian Scientific Society of Cardiology. Among draft age persons, such RF as genetic predisposition, smoking, overweight, and sedentary lifestyle have primary importance in the development of AH. Among patients diagnosed with hypertension these risk factors are most common.
Pharmateca. 2014;(20):66-69
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Opyt primeneniya Eskuzana v lechenii khronicheskoy venoznoy nedostatochnosti u bol'nykh pozhilogo i starcheskogo vozrasta

Dibirov M.D., Gadzhimuradov R.U., Kakubava M.R.

Abstract

The article presents the analysis of results of treatment of 223 patients with 2-3 degree chronic venous insufficiency (CVI), which developed against the background of varicose vein disease and postthrombophlebitic disease. The results of treatment with nicotinic acid + troxerutin, Aescusan+Actovegin, and irregular systemic and topical therapy with phlebotonics and use of compression hosiery were compared. It was shown that the combination treatment of CVI using Aescusan+Actovegin is the most effective method and leads to a decrease of fibrinogen levels and prothrombin index in the peripheral blood, reduce swelling and pain syndrome, and leads to greater healing of trophic ulcers. Thus, the use of phlebotropic drugs (Aescusan) in combination with Actovegin allows to improve clinical outcomes, reduce the length of hospital stay and reduce treatment costs.
Pharmateca. 2014;(20):70-74
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Osobennosti interstitsial'nogo porazheniya legkikh po dannym komp'yuternoy tomografii vysokogo razresheniya u bol'nykh revmatoidnym artritom v zavisimosti ot vospalitel'noy aktivnosti i dlitel'nosti zabolevaniya

Bestaev D.V., Bozh'eva L.A.

Abstract

The article presents the results of the evaluation of the data of high-resolution computed tomography (CT) of the lung in 113 patients with rheumatoid arthritis (RA) with interstitial lung disease (ILD) with various inflammatory activity and duration of the disease. It has been shown that ILD in RA is characterized by predominant involvement of lower basal lung segments in process. Increasing number of affected segments of the lung and the severity of structural changes in the interstitium is correlated with the duration of RA. Symptom of «frosted glass», CT-symptom in ILD, is associated with inflammatory activity of RA and damage of the lower basal segments, and CT symptom of «honeycomb lung» is associated with involvement of all parts of the lungs, and low to moderate inflammatory activity of the disease.
Pharmateca. 2014;(20):75-78
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Neyrometabolicheskaya terapiya v kompleksnom konservativnom lechenii epilepsii

Bektoshev R., Ergashev M., Bektoshev O.

Abstract

The efficacy of using of intravenous Actovegin (250 ml of a 20% solution) in the treatment of 42 patients with pharmacoresistant epilepsy (24 men, 18 women aged 30 to 40 years) was evaluated. Dynamic determination of residual oxidability of cerebrospinal fluid, electroencephalogram and magnetic resonance imaging of the brain were performed. As a result of therapy, the gradual regression of signs of cerebral metabolism insufficiency, reflected in the reduction of morphological and pathophysiological features of epilepsy, was observed.
Pharmateca. 2014;(20):79-80
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Kompleksnoe lechenie ostrykh respiratornykh zabolevaniy. Vzglyad otorinolaringologa na vozmozhnosti sovremennoy farmakoterapii

Ovchinnikov A.Y., Panyakina M.A., Mityuk A.M., Korostelev S.A.

Abstract

The article presents the results of the evaluation of the effectiveness and tolerability of the drug, containing analgesic, sympathomimetic, antitussive, and vitamin, in the therapy of 48 patients with acute respiratory viral infection (ARVI). The use of this drug, including the components that affect the various stages of pathogenesis, seems more optimal treatment for ARVI compared to the set of different drugs and does not lead to negative effects associated with polypharmacy and irrational combinations of drugs.
Pharmateca. 2014;(20):81-84
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Effektivnost' vitaminov gruppy V pri lechenii boley v spine

Strokov I.A., Drokonova O.O., Golovacheva V.A., Akhmedzhanova L.T.

Abstract

Clear antinociceptive effect of B vitamins (В1, В6, B12) and complex preparations of B vitamins (Milgamma) administrated by injection allows their use in acute and chronic back pain, as evidenced in experimental and clinical studies of B vitamins in nociceptive and neuropathic pains.
Pharmateca. 2014;(20):85-90
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Ribosomal'naya immunokorrektsiya pri lechenii allergicheskogo rinita

Sobolev A.V., Aak O.V.

Abstract

The article considers the efficiency of use of the drug on the basis of ribosomal-proteoglycan complex (RPC) of the most common pathogens of ENT and upper respiratory tract infections in the comprehensive therapy of allergic rhinitis, including allergic rhinitis against the background of respiratory tract infections. The interrelation between respiratory infections and atopy is discussed. The data on the immunomodulatory activity of the RPC, including its ability to shift Th1/Th2 balance towards a Th1-type immune response, are presented. This is reflected in the change of cytokine profile and decrease of the degree of atopy.
Pharmateca. 2014;(20):91-95
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