Пути улучшения эффективности эндокринотерапии рака молочной железы: новые таргетные мишени, новые терапевтические возможности


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Аннотация

Преодоление резистентности к эндокринотерапии является одним из наиболее сложных аспектов лечения рака молочной железы (РМЖ). Исследования резистентности к гормональной терапии показали фундаментальную роль перекрестных сигнальных путей во взаимодействии с рецепторами эстрогенов, определяющих резистентность (пути PI3K/AKT/mTOR). Ингибитор mTOR эверолимус улучшает выживаемость больных гормон-рецептор-положительным РМЖ. Активация пути CDK4/CDK6/E2Tявляется частым признаком люминального ER+РМЖ. Комбинация ингибитора CDK4/6 рибоциклиба с летрозолом продемонстрировала достоверное увеличение беспрогрессивной выживаемости в сравнении с летрозолом+плацебо. Комбинация ингибитора CDK 4/6 палбоциклиба и фулвестранта показала значительное улучшение беспрогрессивной выживаемости по сравнению с фулвестрантом+плацебо.

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Об авторах

В. Ф Семиглазов

НИИ онкологии им. Н.Н. Петрова

В. В Семиглазов

Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова

К. С Николаев

НИИ онкологии им. Н.Н. Петрова

Email: kirill.nikolaev87@gmail.com
врач-онколог, науч. сотр. отделения опухолей молочной железы

Г. А Дашян

НИИ онкологии им. Н.Н. Петрова

А. В Комяхов

НИИ онкологии им. Н.Н. Петрова

Р. М Палтуев

НИИ онкологии им. Н.Н. Петрова

В. С Апполонова

НИИ онкологии им. Н.Н. Петрова

Р. В Донских

НИИ онкологии им. Н.Н. Петрова

А. И Целуйко

НИИ онкологии им. Н.Н. Петрова

Т. Ю Семиглазова

НИИ онкологии им. Н.Н. Петрова

Е. К Жильцова

НИИ онкологии им. Н.Н. Петрова

П. В Криворотько

НИИ онкологии им. Н.Н. Петрова

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