Ways to improve efficiency of endocrino-therapy of breast cancer: new targeted cells, new therapeutic opportunities


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Abstract

Overcoming the resistance to endocrine therapy is one of the most difficult aspects of breast cancer (BC) treatment. Studies on resistance to hormonal therapy have shown the fundamental role of cross-signaling pathways in interaction with the estrogen receptors determining resistance (PI3K/AKT/mTOR pathways). The mTOR inhibitor everolimus improves the survival of patients with hormone-receptor-positive breast cancer. Activation of the CDK4/CDK6/E2T pathway is a frequent sign of luminal ER+BC. The combination of CDK 4/6 inhibitor ribociclib and letrozol demonstrated a significant improvement in progression-free survival compared to letrozol+placebo. The combination of CDK4/6 inhibitor palbociclib and fulvestrant showed a significant improvement in progression-free survival compared to fulvestrant+placebo.

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About the authors

V. F Semiglazov

SRI of Oncology n.a. N.N. Petrov

V. V Semiglazov

St. Petersburg State Medical University n.a. Acad. I.P. Pavlov

Kirill S. Nikolaev

SRI of Oncology n.a. N.N. Petrov

Email: kirill.nikolaev87@gmail.com
Oncologist, Researcher at the Department of Breast Tumors

G. A Dashyan

SRI of Oncology n.a. N.N. Petrov

A. V Komyakhov

SRI of Oncology n.a. N.N. Petrov

R. M Paltuev

SRI of Oncology n.a. N.N. Petrov

V. S Appolonova

SRI of Oncology n.a. N.N. Petrov

R. V Donskikh

SRI of Oncology n.a. N.N. Petrov

A. I Tseluyko

SRI of Oncology n.a. N.N. Petrov

T. Yu Semiglazova

SRI of Oncology n.a. N.N. Petrov

E. K Zhiltsova

SRI of Oncology n.a. N.N. Petrov

P. V Krivorotko

SRI of Oncology n.a. N.N. Petrov

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