Фармакологическое действие и клиническое применение цитиколина: обзор экспериментальных данных и клинических исследований


Цитировать

Полный текст

Открытый доступ Открытый доступ
Доступ закрыт Доступ предоставлен
Доступ закрыт Доступ платный или только для подписчиков

Аннотация

Цитидин 5-дифосфохолин (ЦДФ-холин, или цитиколин) является незаменимым промежуточным веществом в биосинтезе структурных фосфолипидов в клеточных мембранах, в частности фосфатидилхолина. Обзор посвящен исследованиям препарата цитиколин. Освещены экспериментальные данные его влияния на травматическое повреждение и экспериментальный отек головного мозга, а также результаты клинического применения при черепно-мозговой травме и ее последствиях.

Полный текст

Доступ закрыт

Об авторах

М. Е Сергиенко

Дорожная клиническая больница на ст. Челябинск ОАО РЖД

Email: smarfor@mail.ru
врач-невролог, врач высшей квалификационной категории

Список литературы

  1. Grieb P. Neuroprotective properties of citicoline: facts, doubts and undersolved issues. CNS. Drugs. 2014;28:185-93. doi: 10.1007/s40263-014-0144-8.
  2. Martinez M., Conde C., Ballabriga A. Some chemical aspects of human brain development II Phosphoglictride fatty acids. Pediatr Res. 1974;9:93-U)2.
  3. Gonzalez-Padrones T., Rodriguez-Fernandez C. Los fosfolipidos como indice de maduracion cerebral. Rev Clin Esp. 1982;167:99-101.
  4. Padmini S., Srinivasa Rao P. UPDgalactos: ceramide galactosyltransferase, CDF choline in maijor regions of the developing rat brain in nutritional stress. Neurosci Res. 1989;23:310-15.
  5. Bramanti V., Bronzi D., Tomassoni D., et al. Effects of choline-containing phospholipids on transglutaminase activity in primary astroglial cell cultures. Clin Exp Hypertens. 2008;30:798-807. doi: 10.1080/10641960802563576.
  6. Paoletti L., Domizi P., Marcucci H., et al. Lisophosphatidilcholine drives neuroblast cell fate. Mol. Neurobiol. 2016;53(9):63 1 6-31. doi: 10.1007/s12035-015-9528-0.
  7. Lozano R. La membrane neuronal: implicaciones terapeuticas. Boletin de Neurol. 1993;2:3-8.
  8. McMurray W.C., Magee WL. Phospholipid metabolism. Ann Rev Biochem. 1972;41:129-61.
  9. Nilsson B. CDP-choline: a shot review. Drug treatment and prevention in cerebrovascular disorders. Amsterdam: Elsvier/North Holland Biomedical Press. 1979. P. 273-77.
  10. Agut J. Neurotransmissores y membrane neuronal. Rev Esp Geriatr Gerontol. 1989;24:16-21.
  11. Albergina M., Giuffrida-Stella A.M. Changes of phospholipidmetabolizing and lysosomal enzymes in hypoglossal nucleus and ventral horn motoneurons during regeneration of craniospinal nerves. J. Neurochem. 1988;51:15-20.
  12. Boismare F. Souffrance cerebraile: cjmportment et neurotransmetteurs sur des modeles experimentaux. 1980.
  13. Hayaishi O., Ozawa K., Araki C., et al. Biochemical studies of head injury and brain edema. Jpn J. Med Prog. 1961;48:519-39.
  14. Homayoun P., Parkins N.E., Soblosky J., et al. Cortical impact injury in rats promoters a rapid and sustained increase in polyunsaturated free fatty acids and diacylgiycerols. Neurochem Res. 2000;25:269-76.
  15. De la Morena E., Goldberg D.M., Werner M. Citidindifosfato de cjlina y biosintes de fosfolipidos. Barselona: Salvat, 1985. P. 25-38.
  16. Vance D.E., Pelech S.L. Cellular translocation of CTP:phosphocholine cytydyltransferase regulates the synthesis of CDPcholine. Amsterdam: Elsevier Science Publishing, 1985. P. 15-24.
  17. Tayebati S.K., Amenta F. Choline-containing phospholipids: relevance to brain functional pathways. Clin Chem Lab Med. 2013;51:513-21. doi: 10.1515/cclm-2012-0559.
  18. Ogasiwa M., Takeuchi K., Hara M., et al. Studies on the intrathecal pharmacotherapy. Part I: CDPcholine. Int J. Clin Pharmacol. 1975;12:327-35.
  19. Watanabe S., Kono S., Nakashima Y., et al. Effects of varios cerebral metabolic activators on glucose metabolism of brain. Folia Psychiat Neurol Jpn. 1975;29:67-76.
  20. Arrigoni E., Averet N., Cohadon F. Effects of CDP-choline on phospholipase A2 and cholinephosphotransferase activities following a cryogenic brain injury in the rabbit. Biochem Pharmacjl. 1987;36:3697-700.
  21. Freysz L., Golly F., Mykita S., et al. Metabolism of neuronal cell culture: Modifications induced by CDP-choline. Novel biochemical, pharmacological and clinical aspects CDP-choline Amsterdam: Elsevier Science Publishing, 1985. P. 117-25.
  22. Algate D.R., Beard D.J., Sacristan A., et al. Study on the effects of oral administration CDP-choline on EEG changes and lethality induced by epidural compression in the anesthetized cat. Arzneimittelforschung. 1983;33(2):1013-16.
  23. Hayaishi O., Ozawa K., Araki C., et al. Biochemical studies of head injury and brain edema. Jpn J. Med Prog. 1961;48:519-39.
  24. Kondo Y. Experimental study of the therapeutic use of cytidine nucleotids for brain injury. Nihon Geka Hokan. 1964;32:489-505.
  25. Boismare F., LePoncin M., et al. Etude des effets de la administration de cytidinediphosphocholine sur les consequences hemodynamiques, fonctionelles, et biochimiques du traumatisme cranioctrvical chez le rat. Therapie. 1977;32:345-54.
  26. Dixon C.E., Ma X., Marion D.W. Effects of CDP-choline treatment on neurobehavioral deficits after TBI and on hippocampal and neocortical acetylcholine release. J. Neurotrauma. 1997;19:161-69.
  27. Baskaya M.K., Dogan A., Rao A.M., et al. Neuroprotective effects of citicoline on brain edema and blood-brain barrier breakdown after traumatic brain injury. J. Neurosurg. 2000;92:448-52.
  28. Cakir E., Usul H., Peksoylu B., et al. Effects of citicoline on experimental spinal cord injury. J. Clin Neurosci. 2005;12:924-27.
  29. Wang L., Rouleau D.M., Beamont E. Most effective adjuvant tretments after surgery in peripheral nerve laceration: systematic review of the literature on rodent models. Restor Neurol Neurosci. 2013;31:253-62. doi: 10.3233/RNN-120253.
  30. Levin H.S. Treatment of postconcussional symptoms with CDP-choline. J. Neurol Sci. 1991;103:39-42.
  31. Anniruddha T.J., Pillai S., Devi B.I., et al. Role of citicoline in the management of mild head injury. Indian J. Neurotrauma. 2009;6:49-52. doi: 10.1080/02699050802132495.
  32. Leon-Carrion J., Dominguez-Roldan J.M., Murillo-Cabezas F., et al. Advances in the treatment of memory deficits after citicholine. 3rd World Congress on Brain Injury. Quebec, 1999.
  33. Leon-Carrion J., Dominguez-Roldan J.M., Murillo-Cabezas F., et al. Normalization of memory-related cerebral blood flow in severe traumatic brain injury patients and improvements of memory induced by citicholine (CDP-choline): the role of a pro-cogntive drug. ICRAN 99. Taiwan, 1999.
  34. Leon-Carrion J., Dominguez-Roldan J.M., Murillo-Cabezas F., et al. The role of citicholine in neuropsycholjgical training after traumatic brain injury. Neurorehabilitation. 2000;14:33-40.
  35. Wortzel H.S., Arciniegas D.B. Treatment of post-traumatic cognitive impairments. Curr Treat Options Neurol. 2012;14:493-508. doi: 10.1007/s11940-012-0193-6.
  36. Spiers PA., Hochanadel G. Citicoline for traumatic brain injury: report of two cases, including my own. J. Int. Neuropsychol Soc. 1999;5:260-64.
  37. Chinnock P., Pokkunuri V. CDP-choline for acute traumatic brain injury. Cochrane Database Syst Rev. 2005;3:CD005402.
  38. Zafonte R., Friedewald W.T., Lee S.M., et al. The citicoline brain injury treatment (COBRIT) trial: design and methods. J. Neurotrauma. 2009;26:2207-16. Doi: 10.1089/ neu.2009.1015.
  39. Zafonte R.D., Bagiella E., Ansel B.M., et al. Effect of citicoline on functional and cognitive status among patients with traumatic brain injury: Citicoline Brain Injury Treatment Trial (COBRIT). JAMA. 2012;308:1993-2000. Doi: 10.1001/ jama.2012.13256.
  40. Secades J.J. Citicoline for the treatment of head injury: a systematic review and meta-analysis of controlled clinical trials. J. Trauma Treat. 2014;4:227.
  41. Sayed I., Zaki A., Fayed A.M., et al. A metaanalysis of the different neuroprotective drugs in management of patients with traumatic brain injury. Neurosurg Rev. 2018;41(2):427-38. doi: 10.1007/s10143-016-0775-y.
  42. El Reweny E.M., Okasha A., Hafez A. The neuroprotective effect of citicholine (CDP choline) in patients with traumatic brain injury, 25th ESICM Annual Congress, Lisbon, Portugal, 2012.
  43. Salehpour F., Shokouhi G., Shakeri M., et al. Neuroprotective effects of citicoline in diffuse axonal injuries. Adv Biosci Clin Med. 2013;1:12-5.

Дополнительные файлы

Доп. файлы
Действие
1. JATS XML
Скачать

Данный сайт использует cookie-файлы

Продолжая использовать наш сайт, вы даете согласие на обработку файлов cookie, которые обеспечивают правильную работу сайта.

О куки-файлах