Pharmacological action and clinical use of the citicoline: a review of experimental data and clinical studies


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Abstract

Cytidine 5-diphosphocholine (CDP-choline, or citicoline) is an essential intermediate substance in the biosynthesis of structural phospholipids in cell membranes, in particular phosphatidylcholine. The review is devoted to the studies of citicoline. The experimental data on its effect on traumatic injury and experimental cerebral edema, as well as the results of clinical use in traumatic brain injury and its consequences, are discussed.

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About the authors

Mariya E. Sergienko

Road Clinical Hospital at the station «Chelyabinsk» JSC «Russian Railways»

Email: smarfor@mail.ru
Neurologist, Doctor of of the highest qualification category

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