Molecular cellular mechanisms of therapeutic action of probiotic drugs


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The data for molecular-cellular mechanisms of immunomodulatory effects of probiotics are presented. The fundamentally actions of these drugs are ability of interact surface structures and DNA of these symbiotic bacteria with Toll-like receptors. Important role play living bacterial cells of probiotic strains as well as their metabolites and antigenic complexes, because they mediate signaling pathways after ligand-retseptor contact with the dendrites, epithelial cells, and many other immunocompetent cells of innate immunity. Probiotics' properties of the drug in addition to immunomodulating activity of the introduced species are largely dependent on the used strain of probiotic. However, only clinical data allow us to select the optimal therapeutic and preventive probiotic.

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V Bondarenko

V Bondarenko

参考

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