DRUG TREATMENT OF PATIENTS WITH ACROMEGALY, PARTIALLY RESISTANT TO THERAPY WITH SOMATOSTATIN ANALOGS


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The article focuses on the problem of treatment of patients with active acromegaly partially resistant to therapy with somatostatin analogues (SA). The review of clinical studies on medical treatment of acromegaly with octreotide and lanreotide is presented; aspects of the effectiveness of these analogues are discussed. The effectiveness of increasing doses of the SA and the combined treatment with dopamine agonists and SA in patients of this group are analyzed. The options for differentiated management in the absence of disease control against the background of monotherapy with SA are proposed.

参考

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